Search Results - "Bloemers, Jos"

Methods for assessing and controlling placebo effects by Kessels, Rob, Mozer, Reagan, Bloemers, Jos

“…The placebo serves as an indispensable control in many randomized trials. When analyzing the benefit of a new treatment, researchers are often confronted with…”
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A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups by Höhle, Daniël, van Rooij, Kim, Bloemers, Jos, Pfaus, James G, Michiels, Frits, Janssen, Paddy, Claassen, Eric, Tuiten, Adriaan

“…Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations of Single-Nucleotide…”
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Multilevel analyses of on-demand medication data, with an application to the treatment of Female Sexual Interest/Arousal Disorder by Kessels, Rob, Bloemers, Jos, Tuiten, Adriaan, van der Heijden, Peter G M

“…Data from clinical trials investigating on-demand medication often consist of an intentionally varying number of measurements per patient. These measurements…”
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Long-term safety and efficacy of zilucoplan in patients with generalized myasthenia gravis: interim analysis of the RAISE-XT open-label extension study by Howard, Jr, James F, Bresch, Saskia, Farmakidis, Constantine, Freimer, Miriam, Genge, Angela, Hewamadduma, Channa, Hinton, John, Hussain, Yessar, Juntas-Morales, Raul, Kaminski, Henry J, Maniaol, Angelina, Mantegazza, Renato, Masuda, Masayuki, Nowak, Richard J, Sivakumar, Kumaraswamy, Śmiłowski, Marek, Utsugisawa, Kimiaki, Vu, Tuan, Weiss, Michael D, Zajda, Małgorzata, Bloemers, Jos, Boroojerdi, Babak, Brock, Melissa, de la Borderie, Guillemette, Duda, Petra W, Vanderkelen, Mark, Leite, M Isabel

“…Generalized myasthenia gravis (gMG) is a chronic, unpredictable disease associated with high treatment and disease burdens, with a need for more effective and…”
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Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial by Tuiten, Adriaan, Michiels, Frits, Böcker, Koen BE, Höhle, Daniël, van Honk, Jack, de Lange, Robert PJ, van Rooij, Kim, Kessels, Rob, Bloemers, Jos, Gerritsen, Jeroen, Janssen, Paddy, de Leede, Leo, Meyer, John-Jules, Everaerd, Walter, Frijlink, Henderik W, Koppeschaar, Hans PF, Olivier, Berend, Pfaus, James G

“…Attempts to develop a drug treatment for female sexual interest/arousal disorder have so far been guided by the principle of ‘one size fits all’, and have…”
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The Effect of Food on the Pharmacokinetics of Buspirone After Single Administration of a Sublingual Testosterone and Oral Buspirone Combination Tablet in Healthy Female Subjects by Gerritsen, Jeroen, Bloemers, Jos, van Rooij, Kim, de Leede, Leo, van der Geest, Ronald, Frijlink, Henderik W., Koppeschaar, Hans P.F., Olivier, Berend, Tuiten, Adriaan

“…A new combination tablet containing sublingual testosterone and oral buspirone (T+B) was developed to benefit a subgroup of women suffering from female sexual…”
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Improvement of fatigue in generalised myasthenia gravis with zilucoplan by Weiss, Michael D., Freimer, Miriam, Leite, M. Isabel, Maniaol, Angelina, Utsugisawa, Kimiaki, Bloemers, Jos, Boroojerdi, Babak, Howard, Emily, Savic, Natasa, Howard, James F.

“…Background Fatigue is a debilitating symptom of myasthenia gravis (MG). The impact of fatigue on MG can be assessed by Quality of Life in Neurological…”
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Long-term safety, efficacy & self-injection satisfaction with zilucoplan in myasthenia gravis: RAISE-XT interim analysis by Genge, Angela, Leite, M. Isabel, Bresch, Saskia, Freimer, Miriam, Hewamadduma, Channa, Hussain, Yessar, Maniaol, Angelina, Mantegazza, Renato, Smilowski, Marek, Utsugisawa, Kimiaki, Vu, Tuan, Duda, Petra W., Boroojerdi, Babak, Vanderkelen, Mark, De La Borderie, Guillemette, Bloemers, Jos, Howard, James F.

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Design of a patient‐ and investigator‐blind, randomized, placebo‐controlled study to evaluate efficacy, safety, and tolerability of bepranemab, UCB0107, in prodromal to mild Alzheimer’s disease: The TOGETHER Study, AH0003 by Barton, Matthew E, Byrnes, William, Mesa, Irene Rebollo, Bloemers, Jos, Maguire, Ralph Paul, Bouw, Rene, Tesseur, Ina, Ewen, Colin, Scheltens, Philip

“…Background Bepranemab is a recombinant, humanized, full‐length immunoglobulin G4 monoclonal antibody that binds to a central tau epitope (amino acids 235–250)…”
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Efficacy of testosterone combined with a PDE5 inhibitor and testosterone combined with a serotonin 1A receptor agonist in women with SSRI-induced sexual dysfunction. A preliminary study by van Rooij, Kim, Poels, Saskia, Worst, Petra, Bloemers, Jos, Koppeschaar, Hans, Goldstein, Andrew, Olivier, Berend, Tuiten, Adriaan

“…Selective serotonin reuptake inhibitors (SSRIs) are known to cause sexual dysfunction, such as decreased sexual motivation, desire, arousal, and orgasm…”
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Toward Personalized Sexual Medicine (Part 2): Testosterone Combined with a PDE5 Inhibitor Increases Sexual Satisfaction in Women with HSDD and FSAD, and a Low Sensitive System for Sexual Cues by Poels, Saskia, Bloemers, Jos, van Rooij, Kim, Goldstein, Irwin, Gerritsen, Jeroen, van Ham, Diana, van Mameren, Frederiek, Chivers, Meredith, Everaerd, Walter, Koppeschaar, Hans, Olivier, Berend, Tuiten, Adriaan

“…Low sexual desire in women may result from a relative insensitivity of the brain for sexual cues. Administration of sublingual 0.5 mg testosterone (T)…”
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Two novel combined drug treatments for women with hypoactive sexual desire disorder by Poels, Saskia, Bloemers, Jos, van Rooij, Kim, Koppeschaar, Hans, Olivier, Berend, Tuiten, Adriaan

“…Low sexual desire is the most common sexual complaint in women. As a result, many women suffer from sexual dissatisfaction which often negatively interferes…”
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Efficacy of testosterone combined with a PDE5 inhibitor and testosterone combined with a serotonin (1A) receptor agonist in women with SSRI-induced sexual dysfunction. A preliminary study by van Rooij, Kim, Poels, Saskia, Worst, Petra, Bloemers, Jos, Koppeschaar, Hans, Goldstein, Andrew, Olivier, Berend, Tuiten, Adriaan

“…Selective serotonin reuptake inhibitors (SSRIs) are known to cause sexual dysfunction, such as decreased sexual motivation, desire, arousal, and orgasm…”
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A multilevel structural equation model for assessing a drug effect on a patient‐reported outcome measure in on‐demand medication data by Kessels, Rob, Moerbeek, Mirjam, Bloemers, Jos, van der Heijden, Peter G.M.

“…We analyze data from a clinical trial investigating the effect of an on‐demand drug for women with low sexual desire. These data consist of a varying number of…”
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Toward Personalized Sexual Medicine (Part 3): Testosterone Combined with a Serotonin1A Receptor Agonist Increases Sexual Satisfaction in Women with HSDD and FSAD, and Dysfunctional Activation of Sexual Inhibitory Mechanisms by van Rooij, Kim, Poels, Saskia, Bloemers, Jos, Goldstein, Irwin, Gerritsen, Jeroen, van Ham, Diana, van Mameren, Frederiek, Chivers, Meredith, Everaerd, Walter, Koppeschaar, Hans, Olivier, Berend, Tuiten, Adriaan

“…Among other causes, low sexual desire in women may result from dysfunctional activation of sexual inhibition mechanisms during exposure to sex. Administration…”
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Toward Personalized Sexual Medicine (Part 1): Integrating the “Dual Control Model” into Differential Drug Treatments for Hypoactive Sexual Desire Disorder and Female Sexual Arousal Disorder by Bloemers, Jos, van Rooij, Kim, Poels, Saskia, Goldstein, Irwin, Everaerd, Walter, Koppeschaar, Hans, Chivers, Meredith, Gerritsen, Jeroen, van Ham, Diana, Olivier, Berend, Tuiten, Adriaan

“…In three related manuscripts we describe our drug development program for the treatment of Hypoactive Sexual Desire Disorder (HSDD). In this first theoretical…”
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Efficacy and Safety of On-Demand Use of 2 Treatments Designed for Different Etiologies of Female Sexual Interest/Arousal Disorder: 3 Randomized Clinical Trials by Tuiten, Adriaan, van Rooij, Kim, Bloemers, Jos, Eisenegger, Christoph, van Honk, Jack, Kessels, Rob, Kingsberg, Sheryl, Derogatis, Leonard R., de Leede, Leo, Gerritsen, Jeroen, Koppeschaar, Hans P.F., Olivier, Berend, Everaerd, Walter, Frijlink, Henderik W., Höhle, Daniël, de Lange, Robert P.J., Böcker, Koen B.E., Pfaus, James G.

“…In women, low sexual desire and/or sexual arousal can lead to sexual dissatisfaction and emotional distress, collectively defined as female sexual…”
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The Effect of Food on the Pharmacokinetics of Sildenafil after Single Administration of a Sublingual Testosterone and Oral Sildenafil Combination Tablet in Healthy Female Subjects by Bloemers, Jos, Gerritsen, Jeroen, van Rooij, Kim, de Leede, Leo, van der Geest, Ronald, Frijlink, Henderik W., Koppeschaar, Hans P.F., Olivier, Berend, Tuiten, Adriaan

“…Female sexual interest/arousal disorder (FSIAD) affects many women worldwide, but pharmacological treatment options are scarce. A new medicine being developed…”
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The Sexual Event Diary (SED): Development and Validation of a Standardized Questionnaire for Assessing Female Sexual Functioning During Discrete Sexual Events by van Nes, Yvonne, Bloemers, Jos, van der Heijden, Peter G.M., van Rooij, Kim, Gerritsen, Jeroen, Kessels, Rob, DeRogatis, Leonard, Tuiten, Adriaan

“…The efficacy of on-demand drugs for hypoactive sexual desire disorder (HSDD) or female sexual interest/arousal disorder (FSIAD) should be assessed using a…”
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Psychometric Properties of the Sexual Event Diary in a Sample of Dutch Women With Female Sexual Interest/Arousal Disorder by van Nes, Yvonne, Bloemers, Jos, Kessels, Rob, van der Heijden, Peter G.M., van Rooij, Kim, Gerritsen, Jeroen, DeRogatis, Leonard, Tuiten, Adriaan

“…Efficacy of on-demand drugs for women with hypoactive sexual desire disorder or female sexual interest/arousal disorder (FSIAD) should be assessed using a…”
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