Search Results - "Bloemendaal, Lysbeth Ten"

The P4-ATPase ATP9A is a novel determinant of exosome release by Naik, Jyoti, Hau, Chi M, Ten Bloemendaal, Lysbeth, Mok, Kam S, Hajji, Najat, Wehman, Ann M, Meisner, Sander, Muncan, Vanesa, Paauw, Nanne J, de Vries, H E, Nieuwland, Rienk, Paulusma, Coen C, Bosma, Piter J

“…Extracellular vesicles (EVs) released by cells have a role in intercellular communication to regulate a wide range of biological processes. Two types of EVs…”
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Reduced spontaneous itch in mouse models of cholestasis by Langedijk, Jacqueline, Bolier, Ruth, Tolenaars, Dagmar, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Waart, Dirk, Beuers, Ulrich, Bosma, Piter, Elferink, Ronald Oude

“…Pruritus is one of the most distressing symptoms in cholestatic patients. Plasma autotaxin (ATX) activity correlates with the severity of pruritus in…”
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Low efficacy of recombinant SV40 in Ugt1a1-/- mice with severe inherited hyperbilirubinemia by Shi, Xiaoxia, Bortolussi, Giulia, Bloemendaal, Lysbeth Ten, Duijst, Suzanne, Muro, Andrés F, Bosma, Piter J

“…In contrast to AAV, Simian Virus 40 (rSV40) not inducing neutralizing antibodies (NAbs) allowing re-treatment seems a promising vector for neonatal treatment…”
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Adeno-associated viral vector serotype 5 poorly transduces liver in rat models by Montenegro-Miranda, Paula S, Pañeda, Astrid, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Waart, Dirk R, Gonzalez- Aseguinolaza, Gloria, Aseguinolaza, Gloria Gonzalez, Bosma, Piter J

“…Preclinical studies in mice and non-human primates showed that AAV serotype 5 provides efficient liver transduction and as such seems a promising vector for…”
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Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1 -/- Mice: Impact on Redox Status and Metabolism by Bortolussi, Giulia, Shi, Xiaoxia, Ten Bloemendaal, Lysbeth, Banerjee, Bhaswati, De Waart, Dirk R, Baj, Gabriele, Chen, Weiyu, Oude Elferink, Ronald P, Beuers, Ulrich, Paulusma, Coen C, Stocker, Roland, Muro, Andrés F, Bosma, Piter J

“…Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause…”
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Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice by Aronson, Sem J., Bakker, Robert S., Shi, Xiaoxia, Duijst, Suzanne, ten Bloemendaal, Lysbeth, de Waart, Dirk R., Verheij, Joanne, Ronzitti, Giuseppe, Oude Elferink, Ronald P., Beuers, Ulrich, Paulusma, Coen C., Bosma, Piter J.

“…[Display omitted] •Adeno-associated virus (AAV)-mediated gene therapy can correct Abcb4 deficiency (PFIC3) in mice.•By restoring phospholipid transport to…”
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The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function by Koelink, Pim J, Gómez-Mellado, Valentina E, Duijst, Suzanne, van Roest, Manon, Meisner, Sander, Ho-Mok, Kam S, Frank, Sabrina, Appelman, Babette S, Bloemendaal, Lysbeth Ten, Vogel, Georg F, van de Graaf, Stan F J, Bosma, Piter J, Oude Elferink, Ronald P J, Wildenberg, Manon E, Paulusma, Coen C

“…Patients with mutations in ATP8B1 develop progressive familial intrahepatic cholestasis type 1 [PFIC1], a severe liver disease that requires life-saving liver…”
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Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients by Shi, Xiaoxia, Aronson, Sem J., ten Bloemendaal, Lysbeth, Duijst, Suzanne, Bakker, Robert S., de Waart, Dirk R., Bortolussi, Giulia, Collaud, Fanny, Oude Elferink, Ronald P., Muro, Andrés F., Mingozzi, Federico, Ronzitti, Giuseppe, Bosma, Piter J.

“…A clinical trial using adeno-associated virus serotype 8 (AAV8)-human uridine diphosphate glucuronosyltransferase 1A1 (hUGT1A1) to treat inherited severe…”
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Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors by Montenegro-Miranda, Paula S, ten Bloemendaal, Lysbeth, Kunne, Cindy, de Waart, Dirk R, Bosma, Piter J

“…Adeno-associated virus (AAV) liver-directed gene therapy seems a feasible treatment for Crigler-Najjar syndrome type I, an inherited liver disorder…”
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A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene by Aronson, Sem J., Bakker, Robert S., Moenis, Sascha, van Dijk, Remco, Bortolussi, Giulia, Collaud, Fanny, Shi, Xiaoxia, Duijst, Suzanne, ten Bloemendaal, Lysbeth, Ronzitti, Giuseppe, Muro, Andrés F., Mingozzi, Federico, Beuers, Ulrich, Bosma, Piter J.

“…Potency assessment of clinical-grade vector lots is crucial to support adeno-associated virus (AAV) vector release and is required for future marketing…”
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Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4−/− mice by Sokolović, Aleksandar, Rodriguez-Ortigosa, Carlos M., Bloemendaal, Lysbeth ten, Oude Elferink, Ronald P.J., Prieto, Jesús, Bosma, Piter J.

“…Adamant progression of chronic cholangiopathies towards cirrhosis and limited therapeutic options leave a liver transplantation the only effective treatment…”
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Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40 by Shi, Xiaoxia, Ykema, Matthew Ryan, Hazenoot, Jaco, Ten Bloemendaal, Lysbeth, Mancini, Irene, Odijk, Machteld, de Haan, Peter, Bosma, Piter J

“…Gene therapy has been shown to be a feasible approach to treat inherited disorders . Among the currently used viral vector systems, adeno-associated virus…”
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Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes by Deurholt, Tanja, van Til, Niek P, Chhatta, Aniska A, ten Bloemendaal, Lysbeth, Schwartlander, Ruth, Payne, Catherine, Plevris, John N, Sauer, Igor M, Chamuleau, Robert Afm, Elferink, Ronald Pj Oude, Seppen, Jurgen, Hoekstra, Ruurdtje

“…A clonal cell line that combines both stable hepatic function and proliferation capacity is desirable for in vitro applications that depend on hepatic…”
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Increased reproducibility of quantitative reverse transcriptase–PCR by Hoekstra, Ruurdtje, Deurholt, Tanja, Poyck, Paul P.C., Bloemendaal, Lysbeth ten, Chhatta, Aniska A.

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In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions by Deurholt, Tanja, ten Bloemendaal, Lysbeth, Chhatta, Aniska A, van Wijk, Albert C W A, Weijer, Kees, Seppen, Jurgen, Elferink, Ronald P J Oude, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Mature human hepatocytes are not suitable for large-scale in vitro applications that rely on hepatocyte function, due to their limited availability and…”
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Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives by Hoekstra, Ruurdtje, Deurholt, Tanja, ten Bloemendaal, Lysbeth, Desille, Mireille, van Wijk, Albert C W A, Clement, Bruno, Oude Elferink, Ronald P J, van Gulik, Thomas M, Chamuleaut, Robert A F M

“…In vitro applications of human hepatocytes, such as bioartificial livers and toxicity assays, require thoroughly testing of human cell lines prior to using…”
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Low efficacy of recombinant SV40 in Ugt1a1.sup.-/- mice with severe inherited hyperbilirubinemia by Shi, Xiaoxia, Bortolussi, Giulia, Bloemendaal, Lysbeth ten, Duijst, Suzanne, Muro, Andrés F, Bosma, Piter J

“…In contrast to AAV, Simian Virus 40 (rSV40) not inducing neutralizing antibodies (NAbs) allowing re-treatment seems a promising vector for neonatal treatment…”
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Time-related analysis of metabolic liver functions, cellular morphology, and gene expression of hepatocytes cultured in the bioartificial liver of the Academic Medical Center in Amsterdam (AMC-BAL) by Poyck, Paul P C, Hoekstra, Ruurdtje, Chhatta, Aniska, Bloemendaal, Lysbeth Ten, van Wijk, Albert C W A, Galavotti, Daniele, van Gulik, Thomas M, Chamuleau, Robert A F M

“…A comprehensive understanding of the mechanisms that underlie hepatic differentiation inside a bioartificial liver (BAL) device is obtained when functional,…”
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Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type I by Shi, Xiaoxia, Bortolussi, Giulia, Collaud, Fanny, Lebrun, Pierre-Romain, Bloemendaal, Lysbeth ten, Guerchet, Nicolas, Rudi de Waart, Dirk, Sellier, Pauline, Duijst, Suzanne, Veron, Philippe, Mingozzi, Federico, Kishimoto, Takashi Kei, Ronzitti, Giuseppe, Bosma, Piter, Muro, Andrés F.

“…Crigler-Najjar syndrome is an ultra-rare monogenic recessive liver disease caused by UGT1A1 gene mutations. Complete UGT1A1 deficiency results in severe…”
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Efficacy of AAV8-h UGT1A1  with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients by Shi, Xiaoxia, Aronson, Sem J, Ten Bloemendaal, Lysbeth, Duijst, Suzanne, Bakker, Robert S, de Waart, Dirk R, Bortolussi, Giulia, Collaud, Fanny, Oude Elferink, Ronald P, Muro, Andrés F, Mingozzi, Federico, Ronzitti, Giuseppe, Bosma, Piter J

“…A clinical trial using adeno-associated virus serotype 8 (AAV8)-human uridine diphosphate glucuronosyltransferase 1A1 (h ) to treat inherited severe…”
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