Search Results - "Block, Timothy M."

Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA by Liu, Yuanjie, Nie, Hui, Mao, Richeng, Mitra, Bidisha, Cai, Dawei, Yan, Ran, Guo, Ju-Tao, Block, Timothy M, Mechti, Nadir, Guo, Haitao

“…Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of a viral RNA pregenome. We report herein that the interferon (IFN) stimulated…”
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Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein by Mao, Richeng, Nie, Hui, Cai, Dawei, Zhang, Jiming, Liu, Hongyan, Yan, Ran, Cuconati, Andrea, Block, Timothy M, Guo, Ju-Tao, Guo, Haitao

“…The zinc finger antiviral protein (ZAP) is a mammalian host restriction factor that inhibits the replication of a variety of RNA viruses, including…”
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Present and future therapies of hepatitis B: From discovery to cure by Liang, T. Jake, Block, Timothy M., McMahon, Brian J., Ghany, Marc G., Urban, Stephan, Guo, Ju‐Tao, Locarnini, Stephen, Zoulim, Fabien, Chang, Kyong‐Mi, Lok, Anna S.

“…Hepatitis B virus (HBV) is a significant global pathogen, infecting more than 240 million people worldwide. While treatment for HBV has improved, HBV patients…”
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Interferon induction of IFITM proteins promotes infection by human coronavirus OC43 by Zhao, Xuesen, Guo, Fang, Liu, Fei, Cuconati, Andrea, Chang, Jinhong, Block, Timothy M., Guo, Ju-Tao

“…IFNs are a family of cytokines that are essential for the antiviral response in vertebrates. Not surprisingly, viruses have adapted to encode virulence factors…”
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Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B by Mitra, Bidisha, Thapa, Roshan J., Guo, Haitao, Block, Timothy M.

“…Similar to other mammalian viruses, the life cycle of hepatitis B virus (HBV) is heavily dependent upon and regulated by cellular (host) functions. These…”
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The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion by Yan, Ran, Zhao, Xuesen, Cai, Dawei, Liu, Yuanjie, Block, Timothy M, Guo, Ju-Tao, Guo, Haitao

“…Interferon alpha (IFN-α) is an approved medication for chronic hepatitis B therapy. Besides acting as an immunomodulator, IFN-α elicits a pleiotropic antiviral…”
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Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions by Chang, Jinhong, Block, Timothy M., Guo, Ju-Tao

“…•ER α-glucosidases are essential host factors for the morphogenesis of many enveloped viruses.•Imino sugars are competitive inhibitors of the ER α-glucosidases…”
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Interferon-Induced Cell Membrane Proteins, IFITM3 and Tetherin, Inhibit Vesicular Stomatitis Virus Infection via Distinct Mechanisms by Weidner, Jessica M, Jiang, Dong, Pan, Xiao-Ben, Chang, Jinhong, Block, Timothy M, Guo, Ju-Tao

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Common concerns, barriers to care, and the lived experience of individuals with hepatitis B: a qualitative study by Freeland, Catherine, Farrell, Sean, Kumar, Priyanka, Kamischke, Maureen, Jackson, Michaela, Bodor, Sierra, Block, Timothy M, Frasso, Rosemary, Cohen, Chari

“…Abstract Background An estimated between 257 and 292 million people live with chronic HBV globally. While much is known about the causes, and epidemiology of…”
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Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation by DAWEI CAI, MILLS, Courtney, CUCONATI, Andrea, HAITAO GUO, WENQUAN YU, RAN YAN, ALDRICH, Carol E, SAPUTELLI, Jeffry R, MASON, William S, XIAODONG XU, GUO, Ju-Tao, BLOCK, Timothy M

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Sulfamoylbenzamide Derivatives Inhibit the Assembly of Hepatitis B Virus Nucleocapsids by Campagna, Matthew R, Liu, Fei, Mao, Richeng, Mills, Courtney, Cai, Dawei, Guo, Fang, Zhao, Xuesen, Ye, Hong, Cuconati, Andrea, Guo, Haitao, Chang, Jinhong, Xu, Xiaodong, Block, Timothy M, Guo, Ju-Tao

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Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections by Jiang, Dong, Weidner, Jessica M, Qing, Min, Pan, Xiao-Ben, Guo, Haitao, Xu, Chunxiao, Zhang, Xianchao, Birk, Alex, Chang, Jinhong, Shi, Pei-Yong, Block, Timothy M, Guo, Ju-Tao

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Characterization of the Intracellular Deproteinized Relaxed Circular DNA of Hepatitis B Virus: an Intermediate of Covalently Closed Circular DNA Formation by Guo, Haitao, Jiang, Dong, Zhou, Tianlun, Cuconati, Andrea, Block, Timothy M, Guo, Ju-Tao

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A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures by Cai, Dawei, Nie, Hui, Yan, Ran, Guo, Ju-Tao, Block, Timothy M, Guo, Haitao

“…Chronic hepatitis B remains a substantial public health burden affecting approximately 350 million people worldwide, causing cirrhosis and liver cancer, and…”
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Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses by Guo, Haitao, Mao, Richeng, Block, Timothy M, Guo, Ju-Tao

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Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation by Guo, Haitao, Xu, Chunxiao, Zhou, Tianlun, Block, Timothy M, Guo, Ju-Tao

“…Synthesis of the covalently closed circular (ccc) DNA is a critical, but not well-understood step in the life cycle of hepadnaviruses. Our previous studies…”
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Identification of Three Interferon-Inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus by Jiang, Dong, Guo, Haitao, Xu, Chunxiao, Chang, Jinhong, Gu, Baohua, Wang, Lijuan, Block, Timothy M, Guo, Ju-Tao

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Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells by JINHONG CHANG, GUO, Ju-Tao, DONG JIANG, HAITAO GUO, TAYLOR, John M, BLOCK, Timothy M

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Use of Current and New Endpoints in the Evaluation of Experimental Hepatitis B Therapeutics by Block, Timothy M., Locarnini, Stephen, McMahon, Brian J., Rehermann, Barbara, Peters, Marion G.

“…New hepatitis B virus (HBV) therapies are expected to have breakthrough benefit for patients. HBV functional cure is sustained hepatitis B surface antigen loss…”
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Indoleamine 2,3-Dioxygenase Mediates the Antiviral Effect of Gamma Interferon against Hepatitis B Virus in Human Hepatocyte-Derived Cells by Mao, Richeng, Zhang, Jiming, Jiang, Dong, Cai, Dawei, Levy, Jessica M, Cuconati, Andrea, Block, Timothy M, Guo, Ju-Tao, Guo, Haitao

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