Search Results - "Blocher, C R"

Chronically increased intra-abdominal pressure produces systemic hypertension in dogs by Bloomfield, G.L, Sugerman, H.J, Blocher, C.R, Gehr, T.W.B, Sica, D.A

“…OBJECTIVE: Determine if increased intra-abdominal pressure (IAP) alone can cause systemic hypertension in a chronic canine model. DESIGN: Evaluate effects of…”
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Pretreatment with inhaled nitric oxide inhibits neutrophil migration and oxidative activity resulting in attenuated sepsis-induced acute lung injury by Bloomfield, Geoffrey L, Holloway, Sharon, Ridings, Philip C, Fisher, Bernard J, Blocher, Charles R, Sholley, Milton, Bunch, Thomas, Sugerman, Harvey J, Fowler, Alpha A

“…OBJECTIVE To determine if, and by what mechanisms, inhaled nitric oxide attenuates acute lung injury in a porcine model of adult respiratory distress syndrome…”
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Tumor necrosis factor-α blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation by WINDSOR, A. C. J, WALSH, C. J, MULLEN, P. G, COOK, D. J, FISHER, B. J, BLOCHER, C. R, LEEPER-WOODFORD, S. K, SUGERMAN, H. J, FOWLER, A. A

“…Tumor necrosis factor (TNF alpha), both by direct action and by trafficking cells of the immune system, is implicated in cardiopulmonary derangements and…”
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A proposed relationship between increased intra-abdominal, intrathoracic, and intracranial pressure by Bloomfield, Geoffrey L, Ridings, Philip C, Blocher, Charles R, Marmarou, Anthony, Sugerman, Harvey J

“…OBJECTIVESTo determine the effect of acutely increased intra-abdominal pressure on pleural pressure, intracranial pressure, and cerebral perfusion pressure,…”
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Protective role of synthetic sialylated oligosaccharide in sepsis-induced acute lung injury by Ridings, Philip C, Holloway, Sharon, Bloomfield, Geoffrey L, Phillips, M. L, Fisher, Bernard J, Blocher, Charles R, Sugerman, Harvey J, Fowler, Alpha A., III

“…Philip C. Ridings 1 , Sharon Holloway 2 , Geoffrey L. Bloomfield 1 , M. L. Phillips 3 , Bernard J. Fisher 4 , Charles R. Blocher 1 , Harvey J. Sugerman 1 , and…”
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OPC-6535, a Superoxide Anion Production Inhibitor, Attenuates Acute Lung Injury by Bloomfield, Geoffrey L., Ridings, Philip C., Blocher, Charles R., Fisher, Bernard J., Sugerman, Harvey J., Nagamoto, Hisashi, Fowler, Alpha A.

“…A large body of evidence has demonstrated that inhibition of the neutrophil's oxidant burst attenuates sepsis-induced acute lung injury. The present study…”
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Cardiopulmonary Effects of Raised Intra-Abdominal Pressure before and after Intravascular Volume Expansion by Ridings, Philip C., Bloomfield, Geoffrey L., Blocher, Charles R., Sugerman, Harvey J.

“…The cardiopulmonary effects of acutely elevated intra-abdominal pressure (IAP) were studied in a porcine model to help define more clearly IAP effects in…”
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Pulmonary compliance: early assessment of evolving lung injury after onset of sepsis by Byrne, K, Cooper, K R, Carey, P D, Berlin, A, Sielaff, T D, Blocher, C R, Jenkins, J K, Fisher, B J, Hirsch, J I, Tatum, J L

“…We compared the sensitivity of dynamic (Cdyn) and static lung compliance (CL) with indicators of permeability injury in a model of septic porcine adult…”
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Increased survival time after delayed histamine and prostaglandin blockade in a porcine model of severe sepsis-induced lung injury by Byrne, K, Sielaff, T D, Michna, B, Carey, P D, Blocher, C R, Vasquez, A, Sugerman, H J

“…A combination of cimetidine, diphenhydramine, and ibuprofen has been shown to be an effective treatment in a porcine model of septic acute lung injury. The…”
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Effect of Increased Renal Venous Pressure on Renal Function by Doty, James M., Saggi, Bob H., Sugerman, Harvey J., Blocher, Charles R., Pin, Richard, Fakhry, Itaf, Gehr, Todd W. B., Sica, Domenic A.

“…OBJECTIVE:Acute renal failure is seen with the acute abdominal compartment syndrome (AACS). Although the cause of acute renal failure in AACS may be…”
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A dual-binding antibody to E- and L-selectin attenuates sepsis-induced lung injury by Ridings, P C, Windsor, A C, Jutila, M A, Blocher, C R, Fisher, B J, Sholley, M M, Sugerman, H J, Fowler, 3rd, A A

“…Many studies indicate a pivotal role for neutrophil adhesion in sepsis-associated lung injury. Neutrophil adhesion to endothelium depends on activation and…”
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Failure of methylprednisolone, ibuprofen, or prostacyclin to reduce HCl-induced pulmonary albumin leak in dogs by Buchman, S R, Sugerman, H J, Tatum, J L, Wright, T P, Blocher, C R, Hirsch, J I

“…The purpose of this study was to examine the effects of methylprednisolone (MP), ibuprofen (I), and prostacyclin (PGI2) pretreatment on cardiopulmonary…”
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Treatment of Intracranial Hypertension Using Nonsurgical Abdominal Decompression by Saggi, Bob H., Bloomfield, Geoffrey L., Sugerman, Harvey J., Blocher, Charles R., Hull, Jason P., Marmarou, Anthony P., Bullock, Malcolm R.

“…BACKGROUNDElevated intra-abdominal pressure (IAP) increases intracranial pressure (ICP) and reduces cerebral perfusion pressure (CPP). We evaluated a…”
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Ibuprofen and methylprednisolone in a pig Pseudomonas ARDS model by Harvey, C F, Sugerman, H J, Tatum, J L, Sielaff, T D, Lee, E C, Blocher, C R

“…The effects of ibuprofen (I) and methylprednisolone (M) were studied in the Pseudomonas porcine model of adult respiratory distress syndrome (ARDS). Four…”
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Myocardial dysfunction and pathology associated with environmental stress in squirrel monkey: effect of vagotomy and propranolol by Corley, K C, Mauck, H P, Shiel, F O, Barber, J H, Clark, L S, Blocher, C R

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Ranitidine compared to cimetidine in multiagent pharmacological treatment of porcine Pseudomonas ARDS by Byrne, K, Sielaff, T D, Carey, P D, Tatum, J L, Blocher, C R, Vasquez, A, Hirsh, J I, Sugerman, H J

“…The effects of two pharmacologically distinct histamine H2 receptor antagonists were studied in combination with ibuprofen (I) and diphenhydramine (D) in a…”
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Beneficial Effects of a Bradykinin Antagonist in a Model of Gram-Negative Sepsis by Ridings, Philip C., Blocher, Charles R., Fisher, Bernard J., Fowler, Alpha A., Sugerman, Harvey J.

“…Activation of the kallikrein-kinin system in sepsis has long been recognized, but its role, beneficial or pathologic, has not been determined. Recently,…”
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Treatment of porcine Pseudomonas ARDS with combination drug therapy by Sielaff, T D, Sugerman, H J, Tatum, J L, Kellum, J M, Blocher, C R

“…A combination drug therapy (Poly-5: ibuprofen 12.5 mg/kg, methylprednisolone 30 mg/kg, cimetidine 150 mg, diphenhydramine 10 mg/kg, and ketanserin 0.2 mg/kg)…”
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Effects of Increased Renal Parenchymal Pressure on Renal Function by Doty, James M., Saggi, Bob H., Blocher, Charles R., Fakhry, Itaf, Gehr, Todd, Sica, Domenic, Sugerman, Harvey J.

“…OBJECTIVEAcute renal failure is seen with the acute abdominal compartment syndrome (AACS). The cause of acute renal failure in AACS is thought to be…”
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In situ pulmonary vascular perfusion for improved recovery of pulmonary intravascular macrophages by Fowler, A A, Carey, P D, Walsh, C J, Sessler, C N, Mumaw, V R, Bechard, D E, Leeper-Woodford, S K, Fisher, B J, Blocher, C R, Byrne, T K

“…The microcirculation contains mononuclear phagocytes, with features characteristic of macrophages, adhered to luminal capillary surfaces by intercellular…”
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