Search Results - "Bloch, Denise"
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Mixture effects of co-formulants and two plant protection products in a liver cell line
Published in EXCLI journal (2023)“…Plant protection products (PPPs) consist of one or more active substances and several co-formulants. Active substances provide the functionality of the PPP and…”
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NAMs: Beta testing needed
Published in Current opinion in toxicology (01-09-2024)“…A variety of new approach methodologies (NAMs) have already been developed for acute systemic and short-term toxicity, including in vitro, in silico, and omics…”
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Toxicokinetic and toxicodynamic mixture effects of plant protection products: A case study
Published in Regulatory toxicology and pharmacology (01-06-2023)“…Authorisation of ready to use plant protection products (PPPs) usually relies on the testing of acute and local toxicity only. This is in stark contrast to the…”
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Effects of co-formulants on the absorption and secretion of active substances in plant protection products in vitro
Published in Archives of toxicology (01-10-2021)“…Currently, the authorisation process for plant protection products (PPPs) relies on the testing of acute and topological toxicity only. Contrastingly, the…”
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Towards a tiered test strategy for plant protection products to address mixture toxicity by alternative approaches in human health assessment
Published in Pest management science (01-10-2020)“…Plant protection products (PPPs) consist of pesticide active substances and co‐formulants. Generally, active substance effects are assumed to dominate in PPP…”
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An approach for mixture testing and prioritization based on common kinetic groups
Published in Archives of toxicology (01-06-2022)“…In light of an ever-increasing exposure to chemicals, the topic of potential mixture toxicity has gained increased attention, particularly as the toxicological…”
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Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations
Published in Regulatory toxicology and pharmacology (01-10-2023)“…Like many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause…”
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Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
Published in Archives of toxicology (01-11-2023)“…Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an ongoing debate if generic “mixture assessment/allocation factors”…”
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The probable future of toxicology - probabilistic risk assessment
Published in ALTEX, alternatives to animal experimentation (01-01-2024)“…Both because of the shortcomings of existing risk assessment methodologies, as well as newly available tools to predict hazard and risk with machine learning…”
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Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology
Published in Archives of toxicology (01-08-2024)Get full text
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Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders
Published in Alternatives to laboratory animals (01-03-2024)“…The first Stakeholder Network Meeting of the EU Horizon 2020-funded ONTOX project was held on 13–14 March 2023, in Brussels, Belgium. The discussion centred…”
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