Search Results - "Blobel, Gunter"

Human TRPML1 channel structures in open and closed conformations by Schmiege, Philip, Fine, Michael, Blobel, Günter, Li, Xiaochun

“…Transient receptor potential mucolipin 1 (TRPML1) is a Ca 2+ -releasing cation channel that mediates the calcium signalling and homeostasis of lysosomes…”
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Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum by Li, Xiaochun, Roberti, Rita, Blobel, Günter

“…Solving the X-ray crystal structure of a Δ 14 -sterol reductase and homologue of human C14SR and DHCR7, two enzymes that reduce specific carbon–carbon double…”
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SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization by Zhao, X, Blobel, G

“…Through a genetic screen using myosin-like protein strains mlp1delta mlp2delta and biochemical purification, we identified a complex of eight proteins, each…”
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Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex by Blobel, Günter, Kampmann, Martin

“…The nuclear pore complex mediates nucleocytoplasmic transport and consists of an assembly of multiple copies of ∼30 different proteins called nucleoporins…”
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Crystal structure and mechanism of human lysine-specific demethylase-1 by Hoelz, André, Stavropoulos, Pete, Blobel, Günter

“…The reversible methylation of specific lysine residues in histone tails is crucial in epigenetic gene regulation. LSD1, the first known lysine-specific…”
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Highway to the inner nuclear membrane: rules for the road by King, Megan C, Lusk, C. Patrick, Blobel, Günter

“…To enter the nucleus a protein must be chaperoned by a transport factor through the nuclear pore complex or it must be small enough to pass through by…”
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Cell Cycle-Regulated Attachment of the Ubiquitin-Related Protein SUMO to the Yeast Septins by Johnson, Erica S., Blobel, Günter

“…SUMO is a ubiquitin-related protein that functions as a posttranslational modification on other proteins. SUMO conjugation is essential for viability in…”
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Polymerization of a Single Protein of the Pathogen Yersinia enterocolitica into Needles Punctures Eukaryotic Cells by Hoiczyk, Egbert, Blobel, Günter

“…A number of pathogenic, Gram-negative bacteria are able to secrete specific proteins across three membranes: the inner and outer bacterial membrane and the…”
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Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string by Hao, Qi, Zhang, Boyue, Yuan, Kangning, Shi, Hang, Blobel, Günter

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Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions by Blus, Bartlomiej Jan, Koh, Junseock, Krolak, Aleksandra, Seo, Hyuk-Soo, Coutavas, Elias, Blobel, Günter

“…Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function…”
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The Karyopherin Kap142p/Msn5p Mediates Nuclear Import and Nuclear Export of Different Cargo Proteins by Yoshida, Kimihisa, Blobel, Günter

“…We have identified a novel pathway for protein import into the nucleus. Although the product of Saccharomyces cerevisiae gene MSN5 was previously shown to…”
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Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN by Napetschnig, Johanna, Blobel, Günter, Hoelz, André

“…The mammalian nuclear pore complex (NPC) is an [almost equal to]120-MDa proteinaceous assembly consisting of [almost equal to]30 proteins and is the sole gate…”
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Popping out of the nucleus by Hoelz, Andre, Blobel, Gunter

“…Previous structural snapshots have provided insight into how proteins are imported into the cell nucleus. The structure of an export complex now completes the…”
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A Novel Ubiquitin-like Modification Modulates the Partitioning of the Ran-GTPase-Activating Protein RanGAP1 between the Cytosol and the Nuclear Pore Complex by Matunis, Michael J., Coutavas, Elias, Blobel, Günter

“…Ran is a nuclear Ras-like GTPase that is required for the bidirectional transport of proteins and ribonucleoproteins across the nuclear pore complex (NPC). A…”
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Three-dimensional organization of chromatids by nuclear envelope-associated structures by Blobel, Günter

“…In evolution, the nuclear envelope (NE) arose from the prokaryotic plasma membrane. NE-associated structures, such as nuclear pore complexes (NPCs), the…”
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Structure of human Niemann–Pick C1 protein by Li, Xiaochun, Wang, Jiawei, Coutavas, Elias, Shi, Hang, Hao, Qi, Blobel, Günter

“…Niemann–Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann–Pick disease type C, and Ebola…”
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Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2 by Li, Xiaochun, Saha, Piyali, Li, Jian, Blobel, Günter, Pfeffer, Suzanne R.

“…Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann–Pick C1 (NPC1) and a soluble protein,…”
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Role of the Nuclear Transport Factor p10 in Nuclear Import by Nehrbass, Ulf, Blobel, Günter

“…The nuclear import factor p10 was cloned from Saccharomyces cerevisiae and found to be essential. The protein p10 can bind directly to several peptide…”
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Cell biology Popping out of the nucleus by Hoelz, André, Blobel, Günter

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Mammalian Karyopherin α1β and α2β Heterodimers: α1or α2Subunit Binds Nuclear Localization Signal and β Subunit Interacts with Peptide Repeat-Containing Nucleoporins by Junona Moroianu, Makoto Hijikata, Gunter Blobel, Aurelian Radu

“…Although only 44% identical to human karyopherin α1, human karyopherin α2(Rch1 protein) substituted for human karyopherin α1(hSRP-1/NPI-1) in recognizing a…”
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