Search Results - "Blobe, G. C."

Loss of type III transforming growth factor-β receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma by Cooper, S J, Zou, H, LeGrand, S N, Marlow, L A, von Roemeling, C A, Radisky, D C, Wu, K J, Hempel, N, Margulis, V, Tun, H W, Blobe, G C, Wood, C G, Copland, J A

“…Loss of transforming growth factor-β receptor III (TβRIII) correlates with loss of transforming growth factor-β (TGF-β) responsiveness and suggests a role for…”
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Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment by Tian, H, Liu, J, Chen, J, Gatza, M L, Blobe, G C

“…Transforming growth factor-β (TGF-β) is an important regulator of breast cancer progression. However, how the breast cancer microenvironment regulates TGF-β…”
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Role of Transforming Growth Factor β in Human Disease by Blobe, Gerard C, Schiemann, William P, Lodish, Harvey F

“…In human tissues, normal homeostasis requires intricately balanced interactions between cells and the network of secreted proteins known as the extracellular…”
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T beta RIII/ beta -arrestin2 regulates integrin alpha 5 beta 1 trafficking, function, and localization in epithelial cells by Mythreye, K, Knelson, E H, Gatza, C E, Gatza, M L, Blobe, G C

“…The type III TGF- beta receptor (T beta RIII) is a ubiquitous co-receptor for TGF- beta superfamily ligands with roles in suppressing cancer progression, in…”
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Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha by BLOBE, G. C, SACHS, C. W, KHAN, W. A, FABBRO, D, STABEL, S, WETSEL, W. C, OBEID, L. M, FINE, R. L, HANNUN, Y. A

“…The multidrug resistance (MDR) phenotype induces cross-resistance to many chemotherapeutic agents in cancer cells. Protein kinase C (PKC) has been implicated…”
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TβRIII/β-arrestin2 regulates integrin α5β1 trafficking, function, and localization in epithelial cells by Mythreye, K, Knelson, E H, Gatza, C E, Gatza, M L, Blobe, G C

“…The type III TGF-β receptor (TβRIII) is a ubiquitous co-receptor for TGF-β superfamily ligands with roles in suppressing cancer progression, in part through…”
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Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence by Venable, M E, Blobe, G C, Obeid, L M

“…Normal cells become senescent in culture after a limited number of population doublings becoming unable to respond to mitogens. This raises the possibility of…”
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Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate by KHAN, W. A, BLOBE, G. C, HANNUN, Y. A

“…Sodium oleate is able to activate soluble protein kinase C (Murakami, K., Chan, S. Y., and Routtenberg, A. (1986) J. Biol. Chem. 261, 15424-15429) but is…”
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Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets by KHAN, W. A, BLOBE, G. C, RICHARDS, A. L, HANNUN, Y. A

“…A novel lipid-dependent protein kinase in human platelets was partially purified and characterized. This enzyme was calcium-independent and was selective for…”
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A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC by Blobe, G C, Liu, X, Fang, S J, How, T, Lodish, H F

“…Transforming growth factor beta (TGF-beta) mediates its biological effects through three high-affinity cell surface receptors, the TGF-beta type I, type II,…”
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters by OBEID, L. M, BLOBE, G. C, KAROLAK, L. A, HANNUN, Y. A

“…The expression of the beta isoenzyme for protein kinase C is regulated developmentally and in response to inducers of cell differentiation (such as phorbol…”
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Protein kinase C: Cellular target of the second messenger arachidonic acid? by Blobe, G.C., Khan, W.A., Hannun, Y.A.

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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades by Schiemann, William P, Blobe, Gerard C, Kalume, Dario E, Pandey, Akhilesh, Lodish, Harvey F

“…Fibulin-5 (FBLN-5; also known as DANCE or EVEC) is an integrin-binding extracellular matrix protein that mediates endothelial cell adhesion; it is also a…”
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Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing by Blobe, G.C., Khan, W.A., Halpern, A.E., Obeid, L.M., Hannun, Y.A.

“…The mechanisms involved in regulating the selective expression of protein kinase C (PKC) isoenzymes are poorly understood. Two human B lymphoblastoid cell…”
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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling by Blobe, G C, Schiemann, W P, Pepin, M C, Beauchemin, M, Moustakas, A, Lodish, H F, O'Connor-McCourt, M D

“…Transforming growth factor beta (TGF-beta) signals through three high affinity cell surface receptors, TGF-beta type I, type II, and type III receptors. The…”
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The type III TGF- receptor signals through both Smad3 and the p38 MAP kinase pathways to contribute to inhibition of cell proliferation by You, H. J., Bruinsma, M. W., How, T., Ostrander, J. H., Blobe, G. C.

“…Transforming growth factor β (TGFβ) has an important role as a negative regulator of cellular proliferation. The type III transforming growth factor β receptor…”
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Regulation of protein kinase C and role in cancer biology by Blobe, G C, Obeid, L M, Hannun, Y A

“…Protein kinase C (PKC) is a family of closely related lipid-dependent and diacyglycerol-activated isoenzymes known to play an important role in the signal…”
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Conformational studies of the nucleic acid binding sites for Xenopus transcription factor IIIA by HUBER, P. W, BLOBE, G. C, HARTMANN, K. M

“…The CD spectrum of a restriction fragment that contains a single copy of a Xenopus borealis somatic 5 S rRNA gene, like those of two smaller fragments from the…”
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C by Khan, Wasiuddin A., Blobe, Gerard C., Hannun, Yusuf A.

“…In addition to serving as the precursor to a plethora of eicosanoids and other bioactive molecules, arachidonate may function as a bona fide second messenger…”
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Protein kinase C beta II specifically binds to and is activated by F-actin by Blobe, G C, Stribling, D S, Fabbro, D, Stabel, S, Hannun, Y A

“…The two most closely related isoenzymes of protein kinase C (PKC), PKC betaI and betaII, are distinct but highly homologous isoenzymes derived via alternative…”
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