Effectiveness of pharmacological preparations in physical exertion

The effect of some drugs used as stimulants of physical performance was measured. The effectiveness was assessed in animals (mice) by means of the Kiplinger swimming procedure and in humans with the aid of the PWC170 test and physiological parameters (respiration rate, pulse rate, oxygen consumption...

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Bibliographic Details
Published in:	Kosmicheskaia biologiia i aviakosmicheskaia meditsina Vol. 9; no. 5; p. 6
Main Authors:	Gordeĭcheva, N V, Shashkov, V S, Kaplan, E Ia, Lakota, N G, Bliznets, N I
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-09-1975
Subjects:	Animals Ephedrine - pharmacology Humans Indomethacin - pharmacology Mice Physical Exertion - drug effects Plant Extracts - pharmacology Strychnine - pharmacology
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Summary:	The effect of some drugs used as stimulants of physical performance was measured. The effectiveness was assessed in animals (mice) by means of the Kiplinger swimming procedure and in humans with the aid of the PWC170 test and physiological parameters (respiration rate, pulse rate, oxygen consumption, oxyhemogram, blood flow rate, rate of oxygen consumption by skin -- Epstein constant). Ephedrine, strychnine, indocete and eleuterococcus were used as stimulants. In animal and human experiments the best results were obtained from the use of an ephedrine-strychnine mixture; the dose for mice -- 0,03 and 0.01 mg/kg, for men -- 0.3 and 0.0015 mg/kg twice a day per os for 10-15 days.
ISSN:	0321-5040