Search Results - "Bliss, Timothy V.P"

Optical Quantal Analysis Reveals a Presynaptic Component of LTP at Hippocampal Schaffer-Associational Synapses by Emptage, Nigel J, Reid, Christopher A, Fine, Alan, Bliss, Timothy V.P

“…The mechanisms by which long-term potentiation (LTP) is expressed are controversial, with evidence for both presynaptic and postsynaptic involvement. We have…”
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Long-term potentiation and long-term depression: a clinical perspective by Bliss, Timothy V.P., Cooke, Sam F

“…Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have…”
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Single Synaptic Events Evoke NMDA Receptor–Mediated Release of Calcium from Internal Stores in Hippocampal Dendritic Spines by Emptage, Nigel, Bliss, Timothy V.P., Fine, Alan

“…We have used confocal microscopy to monitor synaptically evoked Ca 2+ transients in the dendritic spines of hippocampal pyramidal cells. Individual spines…”
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Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome by Galante, Micaela, Jani, Harsha, Vanes, Lesley, Daniel, Hervé, Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Bliss, Timothy V.P., Morice, Elise

“…Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of human chromosome 21 (Hsa21). Recently, O'Doherty et al. [An aneuploid…”
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Behavioral Deficits and Subregion-Specific Suppression of LTP in Mice Expressing a Population of Mutant NMDA Receptors throughout the Hippocampus by Chen, Philip E, Errington, Michael L, Kneussel, Matthias, Chen, Guiquan, Annala, Alexander J, Rudhard, York H, Rast, Georg F, Specht, Christian G, Tigaret, Cezar M, Nassar, Mohammed A, Morris, Richard G.M, Bliss, Timothy V. P, Schoepfer, Ralf

“…The NMDA receptor (NMDAR) subunit GluN1 is an obligatory component of NMDARs without a known functional homolog and is expressed in almost every neuronal cell…”
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Transsynaptic Expression of a Presynaptic Glutamate Receptor During Hippocampal Long-Term Potentiation by Smirnova, Tania, Laroche, Serge, Errington, Michael L., Hicks, Andrew A., Timothy V. P. Bliss, Mallet, Jacques

“…Repetitive activation of excitatory synapses in the hippocampus produces a persistent enhancement of synaptic efficiency known as long-term potentiation (LTP)…”
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Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis by Ying, Shui-Wang, Futter, Marie, Rosenblum, Kobi, Webber, Mark J, Hunt, Stephen P, Bliss, Timothy V. P, Bramham, Clive R

“…Brain-derived neurotrophic factor (BDNF) is implicated in long-term synaptic plasticity in the adult hippocampus, but the cellular mechanisms are little…”
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Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes by O'Doherty, Aideen, Ruf, Sandra, Mulligan, Claire, Hildreth, Victoria, Errington, Mick L, Cooke, Sam, Sesay, Abdul, Modino, Sonie, Vanes, Lesley, Hernandez, Diana, Linehan, Jacqueline M, Sharpe, Paul T, Brandner, Sebastian, Bliss, Timothy V. P, Henderson, Deborah J, Nizetic, Dean, Tybulewicz, Victor L. J, Fisher, Elizabeth M. C

“…Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the…”
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Preservation of Long-Term Memory and Synaptic Plasticity Despite Short-Term Impairments in the Tc1 Mouse Model of Down Syndrome by Morice, Elise, Andreae, Laura C, Cooke, Sam F, Vanes, Lesley, Fisher, Elizabeth M. C, Tybulewicz, Victor L. J, Bliss, Timothy V. P

“…Down syndrome (DS) is a genetic disorder arising from the presence of a third copy of the human chromosome 21 (Hsa21). Recently, O'Doherty and colleagues in an…”
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Long-term potentiation and long-term depression: a clinical perspective by Bliss, Timothy V.P., Cooke, Sam F

“…Long-term potentiation and long-term depression are enduring changes in synaptic strength, induced by specific patterns of synaptic activity, that have…”
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Autophosphorylation of αCaMKII is not a general requirement for NMDA receptor‐dependent LTP in the adult mouse by Cooke, Sam F., Wu, Jianqun, Plattner, Florian, Errington, Michael, Rowan, Michael, Peters, Marco, Hirano, Ayumi, Bradshaw, Karl D., Anwyl, Roger, Bliss, Timothy V. P., Giese, K. Peter

“…Autophosphorylation of α‐Ca2+/calmodulin kinase II (αCaMKII) at Thr286 is thought to be a general effector mechanism for sustaining transcription‐independent…”
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Protein Phosphatase-1 Regulation in the Induction of Long-Term Potentiation: Heterogeneous Molecular Mechanisms by Allen, Patrick B, Hvalby, Oivind, Jensen, Vidar, Errington, Michael L, Ramsay, Mark, Chaudhry, Farrukh A, Bliss, Timothy V. P, Storm-Mathisen, Jon, Morris, Richard G. M, Andersen, Per, Greengard, Paul

“…Protein phosphatase inhibitor-1 (I-1) has been proposed as a regulatory element in the signal transduction cascade that couples postsynaptic calcium influx to…”
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Quantitative three-dimensional confocal microscopy of synaptic structures in living brain tissue by Hosokawa, T, Bliss, T V, Fine, A

“…In order to study changes in synaptic structure that accompany learning and memory, we have developed optical methods to visualize dendritic spines and…”
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