Search Results - "Blind, Michael"

Aptamer Selection Technology and Recent Advances by Blind, Michael, Blank, Michael

“…Over the last decade, aptamers have begun to find their way from basic research to diverse commercial applications. The development of diagnostics is even more…”
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Cytoplasmic RNA Modulators of an Inside-Out Signal-Transduction Cascade by Blind, Michael, Kolanus, Waldemar, Famulok, Michael

“…A vaccinia virus-based RNA expression system enabled high-level cytoplasmic expression of RNA aptamers directed against the intracellular domain of the β 2…”
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Controlling Small Guanine-Nucleotide-Exchange Factor Function through Cytoplasmic RNA Intramers by Mayer, Günter, Blind, Michael, Nagel, Wolfgang, Böhm, Thomas, Knorr, Thomas, Jackson, Catherine L., Kolanus, Waldemar, Famulok, Michael

“…ADP-ribosylation factor (ARF) GTPases and their regulatory proteins have been implicated in the control of diverse biological functions. Two main classes of…”
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Using aptamers as capture reagents in bead-based assay systems for diagnostics and hit identification by Porschewski, Peter, Grättinger, Mira A-M, Klenzke, Kerstin, Erpenbach, Anja, Blind, Michael R, Schäfer, Frank

“…Most applications of xMAP (Luminex) bead-based assay technology in diagnostics and drug discovery use immobilized antigens or antibodies. Here the authors…”
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Nucleic Acid AptamersFrom Selection in Vitro to Applications in Vivo by Famulok, Michael, Mayer, Günter, Blind, Michael

“…Aptamers are nucleic acid ligands which are isolated from combinatorial oligonucleotide libraries by in vitro selection. They exhibit highly complex and…”
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Aptamers as tools for target validation by Blank, Michael, Blind, Michael

“…Synthetic nucleic acid ligands, called aptamers, bind to protein targets with high specificity and affinity. They are very potent inhibitors of protein…”
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Selective Aptamer-Based Control of Intraneuronal Signaling by Lennarz, Sabine, Alich, Therese Christine, Kelly, Tony, Blind, Michael, Beck, Heinz, Mayer, Günter

“…Cellular behavior is orchestrated by the complex interactions of a myriad of intracellular signal transduction pathways. To understand and investigate the role…”
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Nucleic Acid AptamersFrom Selection in Vitro to Applications in Vivo by Famulok, Michael, Mayer, Günter, Blind, Michael

“…Aptamers are nucleic acid ligands which are isolated from combinatorial oligonucleotide libraries by in vitro selection. They exhibit highly complex and…”
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In vitro selection of RNA aptamers that inhibit the activity of type A botulinum neurotoxin by Chang, Tzuu-Wang, Blank, Michael, Janardhanan, Pavithra, Singh, Bal Ram, Mello, Charlene, Blind, Michael, Cai, Shuowei

“…The category A agent, botulinum neurotoxin (BoNT), is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the…”
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An Aptamer to the MAP Kinase Insert Region by Lennarz, Sabine, Heider, Elena, Blind, Michael, Mayer, Günter

“…Targeting functional, non-catalytic domains of protein kinases or other proteins is an emerging field in chemical biology research. Non-ATP competitive kinase…”
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Positive Modulation of the Glycine Receptor by Means of Glycine Receptor-Binding Aptamers by Shalaly, Nancy Dekki, Aneiros, Eduardo, Blank, Michael, Mueller, Johan, Nyman, Eva, Blind, Michael, Dabrowski, Michael A, Andersson, Christin V, Sandberg, Kristian

“…According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach…”
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From selection to caged aptamers: Identification of light-dependent ssDNA aptamers targeting cytohesin by Mayer, Günter, Lohberger, Andrea, Butzen, Sabine, Pofahl, Monika, Blind, Michael, Heckel, Alexander

“…Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo…”
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An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro by Mayer, Günter, Wulffen, Bernhard, Huber, Christian, Brockmann, Jörg, Flicke, Birgit, Neumann, Lars, Hafenbradl, Doris, Klebl, Bert M, Lohse, Martin J, Krasel, Cornelius, Blind, Michael

“…G-protein-coupled receptors are desensitized by a two-step process. In a first step, G-protein-coupled receptor kinases (GRKs) phosphorylate agonist-activated…”
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RNA-Based Approach towards Small-Molecule Inhibitors by Mayer, Günter, Faulhammer, Dirk, Grättinger, Mira, Fessele, Sabine, Blind, Michael

“…Apt for the job: The identification of low‐molecular‐weight protein inhibitors for functional studies as well as for the generation of lead drug compounds is…”
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Aptamers as tools for target prioritization and lead identification by Burgstaller, Petra, Girod, Anne, Blind, Michael

“…The increasing number of potential drug target candidates has driven the development of novel technologies designed to identify functionally important targets…”
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Kinetic Binding Analysis of Aptamers Targeting HIV-1 Proteins by a Combination of a Microbalance Array and Mass Spectrometry (MAMS) by Gronewold, Thomas M. A, Baumgartner, Antje, Hierer, Jessica, Sierra, Saleta, Blind, Michael, Schäfer, Frank, Blümer, Julia, Tillmann, Tina, Kiwitz, Anne, Kaiser, Rolf, Zabe-Kühn, Martin, Quandt, Eckhard, Famulok, Michael

“…An enhanced chip-based detection platform was developed by integrating a surface acoustic wave biosensor of the Love-wave type with protein identification by…”
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Selective Aptamer-Based Control of Intraneuronal Signaling by Lennarz, Sabine, Alich, Therese Christine, Kelly, Tony, Blind, Michael, Beck, Heinz, Mayer, Günter

“…Cellular behavior is orchestrated by the complex interactions of a myriad of intracellular signal transduction pathways. To understand and investigate the role…”
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Microbodies by Schmoldt, Hans-Ulrich, Daneschdar, Matin, Kolmar, Harald, Blind, Michael

“…Microbodies are novel pharmacophoric entities which are derived from naturally occurring cystine-knot microproteins. They provide extremely stable scaffolds…”
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Aptamers that bind to the antibiotic moenomycin A by Schürer, Heike, Stembera, Katherina, Knoll, Dietmar, Mayer, Günter, Blind, Michael, Förster, Hans-Heinrich, Famulok, Michael, Welzel, Peter, Hahn, Ulrich

“…Nuclease-resistant moenomycin-binding aptamers with dissociation constants in the range of 300 to 400 nM have been selected. Competition experiments have…”
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Aptamers that bind to the antibiotic moenomycin A : In vitro selected nucleic acids by SCHÜRER, Heike, STEMBERA, Katherina, KNOLL, Dietmar, MAYER, Günter, BLIND, Michael, FÖRSTER, Hans-Heinrich, FAMULOK, Michael, WELZEL, Peter, HAHN, Ulrich

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