Search Results - "Blessing, William W."

Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé by Ootsuka, Youichirou, Mohammed, Mazher, Blessing, William W.

“…The lateral habenula (LHb) has an important role in the behavioural response to salient, usually aversive, events. We previously demonstrated that activation…”
Get full text

SR59230A, a beta-3 adrenoceptor antagonist, inhibits ultradian brown adipose tissue thermogenesis and interrupts associated episodic brain and body heating by Ootsuka, Youichirou, Kulasekara, Keerthi, de Menezes, Rodrigo Cunha, Blessing, William W

“…Brown adipose tissue (BAT) thermogenesis occurs episodically in an ultradian manner approximately every 80-100 min during the waking phase of the circadian…”
Get more information

Activation of 5-HT1A receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits by Nalivaiko, Eugene, Ootsuka, Youichirou, Blessing, William W

“…The present strategy for the prevention of excessive sympathetic neural traffic to the heart relies on the use of beta-blockers, drugs that act at the heart…”
Get more information

Thermogenesis in brown adipose tissue: Increase by 5-HT2A receptor activation and decrease by 5-HT1A receptor activation in conscious rats by Ootsuka, Youichirou, Blessing, William W.

“…Body temperature is decreased by 5-hydroxytryptamine 1A (5-HT1A) agonists and increased by 5-HT2A agonists. The present study determined whether changes in…”
Get full text

Selective blockade of 5-HT2A receptors attenuates the increased temperature response in brown adipose tissue to restraint stress in rats by Ootsuka, Youichirou, Blessing, William W, Nalivaiko, Eugene

“…Previous studies have demonstrated that 5-HT2A receptors may be involved in the central control of thermoregulation and of the cardiovascular system. Our aim…”
Get more information

Activation of slowly conducting medullary raphe-spinal neurons, including serotonergic neurons, increases cutaneous sympathetic vasomotor discharge in rabbit by Ootsuka, Youichirou, Blessing, William W

“…Neurons in the rostral medullary raphe/parapyramidal region regulate cutaneous sympathetic nerve discharge. Using focal electrical stimulation at different…”
Get more information

Inhibition of rostral medullary raphé neurons prevents cold-induced activity in sympathetic nerves to rat tail and rabbit ear arteries by Ootsuka, Youichirou, Blessing, William W., McAllen, Robin M.

“…Sympathetically-mediated vasoconstriction of cutaneous vessels is critical for thermoregulation in the cold. We determined whether cold-induced sympathetic…”
Get full text

Activating dopamine D2 receptors reduces brown adipose tissue thermogenesis induced by psychological stress and by activation of the lateral habenula by Brizuela, Mariana, Antipov, Anna, Blessing, William W., Ootsuka, Youichirou

“…Emotional hyperthermia is the increase in body temperature that occurs as a response to an animal detecting a salient, survival-relevant stimulus. Brown…”
Get full text

Alpha2-adrenergic receptor agonists prevent emotional hyperthermia by Antipov, Anna, Brizuela, Mariana, Blessing, William W., Ootsuka, Youichirou

“…•Emotionally significant events lead to an increase in body temperature.•Brown adipose tissue (BAT) thermogenesis contributes to emotional hyperthermia.•The…”
Get full text

Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience by Blessing, William W., Blessing, Esther M., Mohammed, Mazher, Ootsuka, Youichirou

“…Rationale We recently introduced a new rat model of emotional hyperthermia in which a salient stimulus activates brown adipose tissue (BAT) thermogenesis and…”
Get full text

Thermoregulation and the ultradian basic rest-activity cycle by Blessing, William W

“…Daily life involves interactions with the external environment. In rats these apparently spontaneous interactions, often associated with the search for food,…”
Get more information

Locus coeruleus noradrenergic innervation of the amygdala facilitates alerting-induced constriction of the rat tail artery by Mohammed, Mazher, Kulasekara, Keerthi, Ootsuka, Youichirou, Blessing, William W

“…The amygdala, innervated by the noradrenergic locus coeruleus, processes salient environmental events. α2-adrenoceptor-stimulating drugs (clonidine-like…”
Get more information

Potential Role of Medullary Raphe-Spinal Neurons in Cutaneous Vasoconstriction: An In Vivo Electrophysiological Study by Nalivaiko, Eugene, Blessing, William W

“…Departments of Physiology and Medicine, Centre for Neuroscience, Flinders University, Bedford Park, SA 5042, Australia Nalivaiko, Eugene and William W…”
Get full text

Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling by Ootsuka, Youichirou, Blessing, William W, Steiner, Alexandre A, Romanovsky, Andrej A

“…PGE2 produced in the periphery triggers the early phase of the febrile response to infection and may contribute to later phases. It can be hypothesized that…”
Get more information

Poster #124 DECREASED HAND BLOOD FLOW CORRELATES WITH SYMPTOM SEVERITY AND IS ACUTELY INCREASED BY ATYPICAL ANTIPSYCHOTIC MEDICATION IN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER by Blessing, Esther, Kader, Linda, Ootsuka, Youichirou, Blessing, William W, Pantelis, Christos

Get full text

Sympathetic cutaneous vasomotor alerting responses (SCVARs) are associated with hippocampal theta rhythm in non-moving conscious rats by de Menezes, Rodrigo Cunha Alvim, Ootsuka, Youichirou, Blessing, William W

“…Abstract Alerting stimuli that cause sympathetic cutaneous vasomotor alerting responses (“SCVARs”) in the thermoregulatory vascular bed of the rabbit ear pinna…”
Get full text

Atypical Antipsychotics Cause an Acute Increase in Cutaneous Hand Blood Flow in Patients with Schizophrenia and Schizoaffective Disorder by Blessing, Esther, Kader, Linda, Arpandy, Reza, Ootsuka, Youichirou, Blessing, William W., Pantelis, Christos

“…Objective: Clinical studies suggest resting thermoregulatory cutaneous vasomotor tone could be increased in schizophrenia, resulting in reduced hand blood…”
Get full text

Activation of 5-HT1A receptors in rostral medullary raphé inhibits cutaneous vasoconstriction elicited by cold exposure in rabbits by Ootsuka, Youichirou, Blessing, William W.

“…In both conscious and anesthetized rabbits, we determined whether microinjection of a 5-hydroxytryptamine (5-HT) 1A receptor agonist 8-hydroxy-2-(di-…”
Get full text

Inhibition of medullary raphé/parapyramidal neurons prevents cutaneous vasoconstriction elicited by alerting stimuli and by cold exposure in conscious rabbits by Ootsuka, Youichirou, Blessing, William W.

“…In conscious rabbits, microinjection of muscimol into the medullary raphé/parapyramidal region decreased fluctuation (coefficient variation) of resting ear…”
Get full text

Spinal 5-HT2A receptors regulate cutaneous sympathetic vasomotor outflow in rabbits and rats; relevance for cutaneous vasoconstriction elicited by MDMA (3,4-methylenedioxymethamphetamine, “Ecstasy”) and its reversal by clozapine by Ootsuka, Youichirou, Nalivaiko, Eugene, Blessing, William W

“…We determined whether spinal 5-hydroxytryptamine 2A (5-HT2A) receptors contribute to resting cutaneous sympathetic vasomotor activity, and to increases in…”
Get full text