Search Results - "Blessin, N C"

Automated Prostate Cancer Identification Facilitates Prognosis Marker Assessment in 11,845 Prostate Cancers Using Artificial Intelligence and BLEACH&STAIN Multiplex Fluorescence Immunohistochemistry by Blessin, N C, Müller, J, Mandelkow, T, Bady, E, Lurati, M C, Lennartz, M, Graefen, M, Sauter, G, Steurer, S

“…Abstract Introduction/Objective Although most prostate cancers behave in an indolent manner, a small proportion is highly aggressive. To evaluate the patient’s…”
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Automated prognosis marker assessment in 2,004 breast cancers using an artificial intelligence-based framework for BLEACH&STAIN multiplex fluorescence immunohistochemistry by Mandelkow, T, Bady, E, Müller, J, Debatin, N F, Lurati, M C, Lennartz, M, Sauter, G, Blessin, N C

“…Abstract Introduction/Objective Introduction: Prognostic markers in routine clinical practice of breast cancer are currently assessed using multi-gene panels…”
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Impact of HER2 assay sensitivity on the ability to detect tumors with low to ultra-low HER2 expression: A TMA study on more than 10,000 tumors from more than 100 tumor entities by Lennartz, M, Blessin, N C, Dum, D, Höflmayer, D, Weidemann, S, Sauter, G, Clauditz, T S, Simon, R, Steurer, S, Burandt, E, Marx, A H

“…Abstract Introduction/Objective Detection of low level HER2 expression is important for therapy with new HER2 inhibitors in breast cancer. HER2 assays with…”
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Diagnostic role and prognostic impact of PSAP immunohistochemistry: A tissue microarray study on 31,358 cancer tissues from 127 different tumor types by Tribian, L S, Lennartz, M, Blessin, N C, Kind, S, Viehweger, F, Menz, A, Burandt, E, Sauter, G, Simon, R, Kluth, M, Bernreuther, C

“…Abstract Introduction/Objective Prostatic specific acid phosphatase (PSAP) protein is produced in prostate epithelial cells and it is used as an…”
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GAD2 is a highly specific marker for neuroendocrine neoplasms of the pancreas by Lennartz, M, Dünnebier, N B, Blessin, N C, Höflmayer, D, Dwertmann Rico, S, Kind, S, Büscheck, F, Sauter, G, Simon, R, Minner, S, Bernreuther, C

“…Abstract Introduction/Objective Glutamate decarboxylase 2 (GAD2) is the most important inhibitory neurotransmitter and plays a role in insulin-producing…”
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TRPS1 is a highly sensitive marker for breast cancer: A tissue microarray study evaluating more than 19,000 tumors from 152 different tumor entities by Lennartz, M, Blessin, N C, Hube-Magg, C, Sauter, G, Simon, R, Dum, D, Minner, S, Clauditz, T S, Bernreuther, C, Steurer, S, Lebok, P

“…Abstract Introduction/Objective TRPS1 (Trichorhinophalangeal syndrome 1) is a nuclear protein expressed in breast epithelial cells. TRPS1 immunohistochemistry…”
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Prostein expression in human tumors: A tissue microarray study on 19,202 tumors by Viehweger, F, Lennartz, M, Blessin, N C, Dum, D, Burandt, E, Sauter, G, Simon, R, Kluth, M, Steurer, S, Clauditz, T S, Kind, S

“…Abstract Introduction/Objective Prostein (P501S), also termed solute carrier family 45 member 3 (SLC45A3) is an androgen regulated protein which is…”
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Comparison of INSM1 immunostaining with established neuroendocrine markers Synaptophysin and Chromogranin A in over 14,000 neuroendocrine and non-neuroendocrine tumors by Möller, K, Gorbokon, N, Hube-Magg, C, Fraune, C, Lennartz, M, Blessin, N C, Sauter, G, Simon, R, Minner, S, Krech, T, Marx, A H

“…Abstract Introduction/Objective INSM1 is a transcription factor protein which is increasingly used as an immunohistochemical marker for neuroendocrine…”
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Steroidogenic acute regulatory (StAR) protein is a useful marker for sex-cord-stroma tumors and normal/neoplastic adrenocortical tissue by Lennartz, M, Amirzada, D, Blessin, N C, Gorbokon, N, Hube-Magg, C, Sauter, G, Simon, R, Kluth, M, Bernreuther, C, Steurer, S, Krech, T

“…Abstract Introduction/Objective Steroidogenic acute regulatory (StAR) protein is a mitochondrial transport protein with a critical regulatory role for steroid…”
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Carcinoembryonic antigen (CEA) expression in human tumors: A tissue microarray study on 15,413 tumors by Jansen, K, Kornfeld, L, Lennartz, M, Blessin, N C, Dwertmann Rico, S, Kind, S, Büscheck, F, Menz, A, Sauter, G, Simon, R, Bernreuther, C

“…Abstract Introduction/Objective Carcinoembryonic antigen (CEA; CEACAM5) is a cell surface glycoprotein which constitutes an attractive therapeutic target and…”
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Cadherin-16 (CDH16) Immunohistochemistry: A Novel Diagnostic Tool for Renal Cell Carcinoma and Papillary Carcinomas of the Thyroid by Lennartz, M, Minner, S, Gorbokon, N, Menz, A, Krech, T, Höflmayer, D, Simon, R, Blessin, N C, Sauter, G, Clauditz, T S, Hinsch, A

“…Abstract Introduction/Objective Introduction: Cadherin-16 (CDH16), also termed kidney specific cadherin (ksp-cadherin), is a membrane-associated glycoprotein…”
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A Comparative Analysis of CPA1, bcl10 and Chymotrypsin for the Distinction of Pancreatic Acinar Cell Carcinomas by Uhlig, R, Minner, S, Luebke, A, Weidemann, S, Lebok, P, Gorbokon, N, Blessin, N C, Lennartz, M, Sauter, G, Jacobsen, F, Clauditz, T S

“…Abstract Introduction/Objective Introduction: Pancreatic acinar cell carcinoma (PACC) is a rare tumor of the pancreas with an intermediate prognosis as…”
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Intraepithelial CD8+ cytotoxic T-cells are the main component of the immune tumor microenvironment that drive prognosis in muscle-invasive bladder cancer by Debatin, N F, Bady, E, Mandelkow, T, Sauter, G, Blessin, N C, Samtleben, H, Horst, D, Marx, A H, Fisch, M, Slojewski, M, Ecke, T, Koch, S, Zecha, H, Schlomm, T, Adamini, N

“…Abstract Introduction/Objective Quantity and the spatial relationship of individual immune cell (sub)types can provide prognostic information in…”
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Upregulation of TIM3 and reduced expression of PD-1 on immune cell subsets in advanced prostate cancers by Blessin, N C, Huang, Z, Debatin, N F, Bady, E, Mandelkow, J Müller T, Simon, R, Lennartz, M, Sauter, G, Clauditz, T S, Burandt, E, Graefen, M, Gorbokon, N

“…Abstract Introduction/Objective Although most prostate cancers behave in an indolent manner, a small proportion is highly aggressive. Both primary and advanced…”
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MYC amplifications are a common event in urothelial bladder carcinomas associated with an aggressive tumor phenotype by Kluth, M, Hitzschke, M, Lennartz, M, Blessin, N C, Sauter, G, Plage, H, Klatte, T, Schlomm, T, Marx, A H, Rink, M, Slojewski, M, Ecke, T, Koch, S, Horst, D, Zecha, H

“…Abstract Introduction/Objective Gene amplifications of the proto-oncogen MYC are common events in carcinomas. In this study, we analyzed the impact of MYC…”
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Semi-automated validation and quantification of CTLA-4 in 90 different Tumor entities using multiple antibodies and artificial intelligence by Dum, D, Blessin, N C, Henke, T L, Mandelkow, T, Bady, E, Raedler, J, Simon, R, Sauter, G, Lennartz, M, Wilczak, W, Burandt, E

“…Abstract Introduction/Objective Introduction: CTLA-4 is an inhibitory immune checkpoint receptor and a negative regulator of anti-tumor T-cell function. This…”
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P02.06 Semi-automated validation and quantification of CTLA-4 in 90 different Tumor entities using multiple antibodies and artificial intelligence by Dum, D, Henke, TLC, Mandelkow, T, Bady, E, Simon, R, Sauter, G, Steuerer, S, Wilczak, W, Burandt, E, Raedler, J, Lennartz, M, Blessin, N C

“…BackgroundCTLA-4 is an inhibitory immune checkpoint receptor and a negative regulator of anti-tumor T-cell function. This study aimed at a comparative analysis…”
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P03.01 Prevalence of CD112R+immune cells in normal lymphatic tissues, inflammation and the cancer microenvironment by Blessin, N C, Mandelkow, T, Bady, E, Hube-Magg, C, Simon, R, Sauter, G, Fraune, C, Lennartz, M, Möller, K, Höflmayer, D, Weidemann, SA

“…BackgroundCD112R is an inhibitory immune checkpoint receptor and a putative target for novel immune therapies, but little is known about its molecular…”
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P02.03 Automated cell type specific PD-L1 quantification by artificial intelligence using high throughput bleach & stain 15-marker multiplex fluorescence immunohistochemistry in human cancers by Blessin, N C, Bady, E, Mandelkow, T, Yang, C, Raedler, J, Simon, R, Fraune, C, Lennartz, M, Minner, S, Burandt, E, Höflmayer, D, Sauter, G, Weidemann, SA

“…BackgroundThe quantification of PD-L1 (programmed cell death ligand 1) has been used to predict patient’s survival, to characterize the tumor immune…”
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P03.06 Pattern of Ki67+expanding CD8+cytotoxic T cells in healthy tissues, inflammation and the cancer microenvironment by Möller, K, Lennartz, M, Abu-Hashem, R, Blessin, N C, Mandelkow, T, Bady, E, Hube-Magg, C, Simon, R, Sauter, G, Fraune, C, Clauditz, T S, Büscheck, F, Luebke, A M

“…BackgroundExpansion of CD8+ cytotoxic T lymphocytes is a prerequisite for anti-cancer immune activity. In the era of immune checkpoint therapy, profound…”
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