Search Results - "Blesch, A."

BDNF: The career of a multifaceted neurotrophin in spinal cord injury by Weishaupt, N., Blesch, A., Fouad, K.

“…Brain-derived neurotrophic factor (BDNF) has been identified as a potent promoter of neurite growth, a finding that has led to an ongoing exploration of this…”
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An improved method for generating human spinal cord neural stem cells by Li, Y., Kumamaru, H., Vokes, T.J., Tran, A.N., Shevinsky, C.A., Graham, L., Archuleta, K., Limon, K.R., Lu, P., Blesch, A., Tuszynski, M.H., Brock, J.H.

“…Neural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently…”
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Local and remote growth factor effects after primate spinal cord injury by Brock, John H, Rosenzweig, Ephron S, Blesch, Armin, Moseanko, Rod, Havton, Leif A, Edgerton, V Reggie, Tuszynski, Mark H

“…Primate models of spinal cord injury differ from rodent models in several respects, including the relative size and functional neuroanatomy of spinal…”
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Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury by Grill, R, Murai, K, Blesch, A, Gage, F. H, Tuszynski, M. H

“…The injured adult mammalian spinal cord shows little spontaneous recovery after injury. In the present study, the contribution of projections in the dorsal…”
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A dual promoter lentiviral vector for the in vivo evaluation of gene therapeutic approaches to axon regeneration after spinal cord injury by Löw, K, Blesch, A, Herrmann, J, Tuszynski, M H

“…The identification of axon growth-promoting genes, and overexpression of these genes in central nervous system (CNS) neurons projecting to the spinal cord, has…”
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Novel aspects of diagnostics and therapy of spinal cord diseases by Rupp, R, Blesch, A, Schad, L, Draganski, B, Weidner, N

“…Both non-traumatic and traumatic spinal cord injuries have in common that a relatively minor structural lesion can cause profound sensorimotor and autonomous…”
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Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1 by Weidner, N., Blesch, A., Grill, R.J., Tuszynski, M.H.

“…Schwann cells contribute to efficient axonal regeneration after peripheral nerve injury and, when grafted to the central nervous system (CNS), also support a…”
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Robust Growth of Chronically Injured Spinal Cord Axons Induced by Grafts of Genetically Modified NGF-Secreting Cells by Grill, R.J., Blesch, A., Tuszynski, M.H.

“…Little spontaneous regeneration of axons occurs after acute and chronic injury to the CNS. Previously we have shown that the continuous local delivery of…”
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Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury by Blesch, A, Uy, H. S, Grill, R. J, Cheng, J.-G, Patterson, P. H, Tuszynski, M. H

“…The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known…”
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Recommended guidelines for studies of human subjects with spinal cord injury by Anderson, D K, Beattie, M, Blesch, A, Bresnahan, J, Bunge, M, Dietrich, D, Dietz, V, Dobkin, B, Fawcett, J, Fehlings, M, Fischer, I, Grossman, R, Guest, J, Hagg, T, Hall, E D, Houle, J, Kleitman, N, McDonald, J, Murray, M, Privat, A, Reier, P, Steeves, J, Steward, O, Tetzlaff, W, Tuszynski, M H, Waxman, S G, Whittemore, S, Wolpaw, J, Young, W, Zheng, B

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Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression by BLESCH, A, CONNER, J. M, TUSZYNSKI, M. H

“…Vector systems for the regulated and reversible expression of therapeutic genes are likely to improve the safety and efficacy of gene therapy for medical…”
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P3.050 Role of tumor necrosis factor in the progressive phase of dopaminergic neuron death in a rat model of Parkinson's disease by Harms, A, Varghese, S, Ruhn, K, Trevino, I, Blesch, A, Tansey, M

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Nerve Replacement Strategies for Cavernous Nerves by May, F., Vroemen, M., Matiasek, K., Henke, J., Brill, T., Lehmer, A., Apprich, M., Erhardt, W., Schoeler, S., Paul, R., Blesch, A., Hartung, R., Gansbacher, B., Weidner, N.

“…This article reviews novel restorative therapies for cavernous nerves that may be used to replace resected cavernous nerves at the time of pelvic surgery. A…”
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Spinal cord injury: plasticity, regeneration and the challenge of translational drug development by Blesch, Armin, Tuszynski, Mark H

“…Over the past three decades, multiple mechanisms limiting central nervous system regeneration have been identified. Here, we address plasticity arising from…”
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Neurotrophin gene therapy in CNS models of trauma and degeneration by Blesch, A, Grill, R J, Tuszynski, M H

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Lentiviral and MLV based retroviral vectors for ex vivo and in vivo gene transfer by Blesch, Armin

“…Retroviral vectors have become an important tool for gene transfer in vitro and in vivo. Classical Moloney murine leukemia virus (MLV) based retroviral vectors…”
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Induction of bone marrow stromal cells to neurons: Differentiation, transdifferentiation, or artifact? by Lu, Paul, Blesch, Armin, Tuszynski, Mark H.

“…Differentiation of stem cells toward a neuronal lineage normally involves a gradually progressive restriction in developmental potential and is regulated by a…”
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Early-onset treadmill training reduces mechanical allodynia and modulates calcitonin gene-related peptide fiber density in lamina III/IV in a mouse model of spinal cord contusion injury by Nees, Timo A., Tappe-Theodor, Anke, Sliwinski, Christopher, Motsch, Melanie, Rupp, Rüdiger, Kuner, Rohini, Weidner, Norbert, Blesch, Armin

“…Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal…”
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Motor axonal regeneration after partial and complete spinal cord transection by Lu, Paul, Blesch, Armin, Graham, Lori, Wang, Yaozhi, Samara, Ramsey, Banos, Karla, Haringer, Verena, Havton, Leif, Weishaupt, Nina, Bennett, David, Fouad, Karim, Tuszynski, Mark H

“…We subjected rats to either partial midcervical or complete upper thoracic spinal cord transections and examined whether combinatorial treatments support motor…”
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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease by Tuszynski, Mark H, Thal, Leon, Pay, Mary, Salmon, David P, U, Hoi Sang, Bakay, Roy, Patel, Piyush, Blesch, Armin, Vahlsing, H Lee, Ho, Gilbert, Tong, Gang, Potkin, Steven G, Fallon, James, Hansen, Lawrence, Mufson, Elliott J, Kordower, Jeffrey H, Gall, Christine, Conner, James

“…Cholinergic neuron loss is a cardinal feature of Alzheimer disease. Nerve growth factor (NGF) stimulates cholinergic function, improves memory and prevents…”
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