Search Results - "Blennow, Kaj"

A Review of Fluid Biomarkers for Alzheimer’s Disease: Moving from CSF to Blood by Blennow, Kaj

“…A set of core cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) includes total tau (T-tau), phosphorylated tau (P-tau) and β-amyloid 42 (Aβ42)…”
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Moving fluid biomarkers for Alzheimer's disease from research tools to routine clinical diagnostics by Zetterberg, Henrik, Blennow, Kaj

“…Four fluid-based biomarkers have been developed into diagnostic tests for Alzheimer's disease (AD) pathology: the ratio of 42 to 40 amino acid-long amyloid β,…”
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Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports by Shahim, Pashtun, Zetterberg, Henrik, Tegner, Yelverton, Blennow, Kaj

“…OBJECTIVE:To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in…”
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The Neuropathology and Neurobiology of Traumatic Brain Injury by Blennow, Kaj, Hardy, John, Zetterberg, Henrik

“…The acute and long-term consequences of traumatic brain injury (TBI) have received increased attention in recent years. In this Review, we discuss the…”
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Developing the ATX(N) classification for use across the Alzheimer disease continuum by Hampel, Harald, Cummings, Jeffrey, Blennow, Kaj, Gao, Peng, Jack, Clifford R., Vergallo, Andrea

“…Breakthroughs in the development of highly accurate fluid and neuroimaging biomarkers have catalysed the conceptual transformation of Alzheimer disease (AD)…”
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Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology by Ashton, Nicholas J., Pascoal, Tharick A., Karikari, Thomas K., Benedet, Andréa L., Lantero-Rodriguez, Juan, Brinkmalm, Gunnar, Snellman, Anniina, Schöll, Michael, Troakes, Claire, Hye, Abdul, Gauthier, Serge, Vanmechelen, Eugeen, Zetterberg, Henrik, Rosa-Neto, Pedro, Blennow, Kaj

“…The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or plasma, has shown great promise in detecting Alzheimer’s disease…”
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Neurofilament light chain as a biomarker in neurological disorders by Gaetani, Lorenzo, Blennow, Kaj, Calabresi, Paolo, Di Filippo, Massimiliano, Parnetti, Lucilla, Zetterberg, Henrik

“…In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and…”
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Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia by Janelidze, Shorena, Mattsson, Niklas, Palmqvist, Sebastian, Smith, Ruben, Beach, Thomas G., Serrano, Geidy E., Chai, Xiyun, Proctor, Nicholas K., Eichenlaub, Udo, Zetterberg, Henrik, Blennow, Kaj, Reiman, Eric M., Stomrud, Erik, Dage, Jeffrey L., Hansson, Oskar

“…Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer’s disease (AD), but its usefulness for differential diagnosis and prognosis is unclear…”
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CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis by Olsson, Bob, Dr, Lautner, Ronald, MD, Andreasson, Ulf, PhD, Öhrfelt, Annika, PhD, Portelius, Erik, PhD, Bjerke, Maria, PhD, Hölttä, Mikko, PhD, Rosén, Christoffer, MD, Olsson, Caroline, PhD, Strobel, Gabrielle, MSc, Wu, Elizabeth, MLIS, Dakin, Kelly, PhD, Petzold, Max, Prof, Blennow, Kaj, Prof, Zetterberg, Henrik, Prof

“…Summary Background Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for…”
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease by Blennow, Kaj, Hampel, Harald, Zetterberg, Henrik, Weiner, Michael

“…The early detection of Alzheimer disease might be critical to the effectiveness of disease-modifying drugs, when such therapies become available. In this…”
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From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease by Zetterberg, Henrik, Blennow, Kaj

“…The past five years have seen an enormous development in the field of fluid biomarkers for Alzheimer's disease (AD) and related disorders. The proteins that…”
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The probabilistic model of Alzheimer disease: the amyloid hypothesis revised by Frisoni, Giovanni B., Altomare, Daniele, Thal, Dietmar Rudolf, Ribaldi, Federica, van der Kant, Rik, Ossenkoppele, Rik, Blennow, Kaj, Cummings, Jeffrey, van Duijn, Cornelia, Nilsson, Peter M., Dietrich, Pierre-Yves, Scheltens, Philip, Dubois, Bruno

“…The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid…”
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Microglial activation and tau propagate jointly across Braak stages by Pascoal, Tharick A., Benedet, Andrea L., Ashton, Nicholas J., Kang, Min Su, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Lussier, Firoza Z., Tissot, Cécile, Karikari, Thomas K., Ottoy, Julie, Mathotaarachchi, Sulantha, Stevenson, Jenna, Massarweh, Gassan, Schöll, Michael, de Leon, Mony J., Soucy, Jean-Paul, Edison, Paul, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD)…”
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Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies by Mattsson-Carlgren, Niklas, Palmqvist, Sebastian, Blennow, Kaj, Hansson, Oskar

“…Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are…”
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Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood by Zetterberg, Henrik, Smith, Douglas H., Blennow, Kaj

“…Mild traumatic brain injury (TBI) is defined as a head trauma resulting in a brief loss of consciousness and/or alteration of mental state. Diagnostic methods…”
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Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative by Karikari, Thomas K., Benedet, Andréa L., Ashton, Nicholas J., Lantero Rodriguez, Juan, Snellman, Anniina, Suárez-Calvet, Marc, Saha-Chaudhuri, Paramita, Lussier, Firoza, Kvartsberg, Hlin, Rial, Alexis Moscoso, Pascoal, Tharick A., Andreasson, Ulf, Schöll, Michael, Weiner, Michael W., Rosa-Neto, Pedro, Trojanowski, John Q., Shaw, Leslie M., Blennow, Kaj, Zetterberg, Henrik

“…Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of…”
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Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change by Smirnov, Denis S., Ashton, Nicholas J., Blennow, Kaj, Zetterberg, Henrik, Simrén, Joel, Lantero-Rodriguez, Juan, Karikari, Thomas K., Hiniker, Annie, Rissman, Robert A., Salmon, David P., Galasko, Douglas

“…Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer’s Disease…”
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Neurofilament light and tau as blood biomarkers for sports-related concussion by Shahim, Pashtun, Tegner, Yelverton, Marklund, Niklas, Blennow, Kaj, Zetterberg, Henrik

“…OBJECTIVETo compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their…”
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Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures by Palmqvist, Sebastian, Tideman, Pontus, Cullen, Nicholas, Zetterberg, Henrik, Blennow, Kaj, Dage, Jeffery L., Stomrud, Erik, Janelidze, Shorena, Mattsson-Carlgren, Niklas, Hansson, Oskar

“…A combination of plasma phospho-tau (P-tau) and other accessible biomarkers might provide accurate prediction about the risk of developing Alzheimer’s disease…”
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Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease by Chatterjee, Pratishtha, Pedrini, Steve, Stoops, Erik, Goozee, Kathryn, Villemagne, Victor L., Asih, Prita R., Verberk, Inge M. W., Dave, Preeti, Taddei, Kevin, Sohrabi, Hamid R., Zetterberg, Henrik, Blennow, Kaj, Teunissen, Charlotte E., Vanderstichele, Hugo M., Martins, Ralph N.

“…Glial fibrillary acidic protein (GFAP), an astrocytic cytoskeletal protein, can be measured in blood samples, and has been associated with Alzheimer’s disease…”
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