Search Results - "Blenis, J."

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways by LIU, L, LI, F, CARDELLI, J. A, MARTIN, K. A, BLENIS, J, HUANG, S

“…Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), inhibits tumor cell motility. However, the underlying mechanism is poorly understood…”
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Signal Transduction via the MAP Kinases: Proceed at Your Own RSK by Blenis, John

“…An explosion of new information linking activation of cell surface signal initiators to changes in gene expression has recently emerged. The focus of much of…”
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Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos by Agrawal, Sudhanshu, Agrawal, Anshu, Doughty, Barbara, Gerwitz, Andrew, Blenis, John, Van Dyke, Thomas, Pulendran, Bali

“…Dendritic cells (DCs) are pivotal in determining the class of an adaptive immune response. However, the molecular mechanisms within DCs that determine this…”
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Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells by Sun, Y, Gu, X, Zhang, E, Park, M-A, Pereira, A M, Wang, S, Morrison, T, Li, C, Blenis, J, Gerbaudo, V H, Henske, E P, Yu, J J

“…Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating…”
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STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation by Chung, Jongkyeong, Uchida, Eriko, Grammer, Timothy C., Blenis, John

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation by Cheatham, B, Vlahos, C J, Cheatham, L, Wang, L, Blenis, J, Kahn, C R

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Nuclear localization and regulation of erk- and rsk-encoded protein kinases by REY-HUEI CHEN, SARNECKI, C, BLENIS, J

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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 by Songyang, Z., Lu, Kun Ping, Kwon, Young T., Tsai, Li-Huei, Filhol, Odile, Cochet, Claude, Brickey, Debra A., Soderling, Thomas R., Bartleson, Cheryl, Graves, Donald J., DeMaggio, Anthony J., Hoekstra, Merl F., Blenis, John, Hunter, Tony, Cantley, Lewis C.

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Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1 by Richards, Stephanie A., Dreisbach, Valley C., Murphy, Leon O., Blenis, John

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Phosphorylation of the c-Fos Transrepression Domain by Mitogen-Activated Protein Kinase and 90-kDa Ribosomal S6 Kinase by Chen, Rey-Huei, Abate, Cory, Blenis, John

“…Phosphorylation of the C terminus of c-Fos has been implicated in serum response element-mediated repression of c-fos transcription after its induction by…”
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Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases by Juo, Peter, Kuo, Calvin J., Reynolds, Susan E., Konz, Richard F., Raingeaud, Joël, Davis, Roger J., Biemann, Hans-Peter, Blenis, John

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Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway by Karnitz, Larry M., Burns, Leigh Ann, Sutor, Shari L., Blenis, John, Abraham, Robert T.

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Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP by Monfar, Mercè, Lemon, Katherine P., Grammer, Timothy C., Cheatham, Lynn, Chung, Jongkyeong, Vlahos, Chris J., Blenis, John

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A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity by RIVERA, V. M, MIRANTI, C. K, MISRA, R. P, GINTY, D. D, REY-HUEI CHEN, BLENIS, J, GREENBERG, M. E

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Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase by TERADA, N, FRANKLIN, R. A, LUCAS, J. J, BLENIS, J, GELFAND, E. W

“…Rapamycin (RAP) has recently been shown to inhibit the phosphorylation and activity of p70 S6 kinase (p70s6k). In interleukin (IL)-2-induced cell activation of…”
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p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation by PAPKOFF, J, REY-HUEI CHEN, BLENIS, J, FORSMAN, J

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A Xenopus Ribosomal Protein S6 Kinase Has Two Apparent Kinase Domains that are Each Similar to Distinct Protein Kinases by Jones, Steven W., Erikson, Eleanor, Blenis, John, Maller, James L., Erikson, R. L.

“…We report the molecular cloning of cDNAs for S6 kinase II (S6KII) mRNAs present in Xenopus ovarian tissue. Two cDNAs were isolated by hybridization to…”
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Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes by Fingar, D.C, Hausdorff, S.F, Blenis, J, Birnbaum, M.J

“…The metabolic and mitogenic actions of insulin have been proposed to be mediated by cellular serine/threonine kinases such as the ribosomal protein S6 kinases…”
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Balancing lysosome abundance in health and disease by Mutvei, Anders P., Nagiec, Michal J., Blenis, John

“…Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis…”
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ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions by ROUX, Philippe P, BLENIS, John

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