Search Results - "Blendy, J A"

Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence by Turner, J R, Ray, R, Lee, B, Everett, L, Xiang, J, Jepson, C, Kaestner, K H, Lerman, C, Blendy, J A

“…Addiction to nicotine and the ability to quit smoking are influenced by genetic factors. We used functional genomic approaches (chromatin immunoprecipitation…”
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Assessment of NMDA receptor NR1 subunit hypofunction in mice as a model for schizophrenia by Halene, T. B., Ehrlichman, R. S., Liang, Y., Christian, E. P., Jonak, G. J., Gur, T. L., Blendy, J. A., Dow, H. C., Brodkin, E. S., Schneider, F., Gur, R. C., Siegel, S. J.

“…N‐methyl‐D‐aspartate receptors (NMDARs) play a pivotal role in excitatory neurotransmission, synaptic plasticity and brain development. Clinical and…”
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Reduced expression of the mu opioid receptor in some, but not all, brain regions in mice with OPRM1 A112G by Wang, Y.-J, Huang, P, Ung, A, Blendy, J.A, Liu-Chen, L.-Y

“…Abstract OPRM1 A118G is a common single nucleotide polymorphism (SNP) in the coding region of the human mu opioid receptor (MOPR) gene OPRM1 . This SNP is…”
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Running‐induced anxiety is dependent on increases in hippocampal neurogenesis by Onksen, J. L., Briand, L. A., Galante, R. J., Pack, A. I., Blendy, J. A.

“…Exercise, specifically voluntary wheel running, is a potent stimulator of hippocampal neurogenesis in adult mice. In addition, exercise induces behavioral…”
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Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms by Eacret, D, Veasey, S C, Blendy, J A

“…Millions of Americans suffer from opiate use disorder, and over 100 die every day from opioid overdoses. Opioid use often progresses into a vicious cycle of…”
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Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons by Riccio, Antonella, Ahn, Sohyun, Davenport, Christopher M., Blendy, Julie A., Ginty, David D.

“…Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB…”
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Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse by Walters, C L, Blendy, J A

“…Addiction is a complex process that relies on the ability of an organism to integrate positive and negative properties of drugs of abuse. Therefore, studying…”
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The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis by Porter, B.E, Lund, I.V, Varodayan, F.P, Wallace, R.W, Blendy, J.A

“…Abstract Alterations in the brain that contribute to the development of epilepsy, also called epileptogenesis, are not well understood, which makes it…”
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repo Encodes a glial-specific homeo domain protein required in the Drosophila nervous system by WEN-CHENG XIONG, OKANO, H, PATEL, N. H, BLENDY, J. A, MONTELL, C

“…We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles were viable but affected glia in the optic lobe, resulting in a…”
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Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior by Jin, S.-H., Blendy, J.A., Thomas, S.A.

“…Analysis of mice with targeted disruptions of fosB or the gene encoding dopamine β-hydroxylase suggests that FosB and adrenergic signaling play critical roles…”
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Targeting of the CREB gene leads to up‐regulation of a novel CREB mRNA isoform by Blendy, J. A., Kaestner, K. H., Schmid, W., Gass, P., Schutz, G.

“…To define the role of cAMP signaling in gene control, we have generated mice with a mutation in the cAMP response element binding protein (CREB) gene. Mice…”
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Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation by Cole, T J, Blendy, J A, Monaghan, A P, Krieglstein, K, Schmid, W, Aguzzi, A, Fantuzzi, G, Hummler, E, Unsicker, K, Schütz, G

“…The role of the glucocorticoid receptor (GR) in glucocorticoid physiology and during development was investigated by generation of GR-deficient mice by gene…”
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α1d Adrenoceptor signaling is required for stimulus induced locomotor activity by SADALGE, A, COUGHLIN, L, FU, H, WANG, B, VALLADARES, O, VALENTINO, R, BLENDY, J. A

“…α1 Adrenergic receptors mediate a variety of physiological responses and have been well studied in the cardiovascular and peripheral nervous system. However,…”
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Severe impairment of spermatogenesis in mice lacking the CREM gene by BLENDY, J. A, KAESTNER, K. H, WEINBAUER, G. F, NIESCHLAG, E, SCHÜTZ, G

“…Spermatogenesis is a complex developmental process that occurs in several phases. A large number of genes have been identified that are expressed during…”
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Transgenerational inheritance of chronic adolescent stress: Effects of stress response and the amygdala transcriptome by Manners, M. T., Yohn, N. L., Lahens, N. F., Grant, G. R., Bartolomei, M. S., Blendy, J. A.

“…Adolescent stress can impact health and well‐being not only during adulthood of the exposed individual but even in future generations. To investigate the…”
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Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB by Maldonado, Rafael, Blendy, Julie A., Tzavara, Eleni, Gass, Peter, Roques, Bernard P., Hanoune, Jacques, Schütz, Günter

“…Chronic morphine administration induces an up-regulation of several components of the cyclic adenosine 5′-monophosphate (cAMP) signal transduction cascade. The…”
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Targeted Mutation of the CREB Gene: Compensation within the CREB/ATF Family of Transcription Factors by Hummler, Edith, Cole, Timothy J., Blendy, Julie A., Ganss, Ruth, Aguzzi, Adriano, Schmid, Wolfgang, Beermann, Friedrich, Schutz, Gunther

“…The cAMP response element binding protein (CREB) has been implicated as a key regulator in the transcriptional control of many genes. To assess the functional…”
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The mouse nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by ap1 by Mackler, S.A, Homan, Y.X, Korutla, L, Conti, A.C, Blendy, J.A

“…NAC1 cDNA was identified as a novel transcript induced in the nucleus accumbens from rats chronically treated with cocaine. NAC1 is a member of the Bric-a-brac…”
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Genetic analysis of drug addiction : the role of cAMP response element binding protein by BLENDY, J. A, MALDONADO, R

“…Many drugs of abuse, administered repeatedly over time, cause physical dependence which is expressed by a withdrawal syndrome when the drug is removed from the…”
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Molecular genetic analysis of glucocorticoid signalling in development by Schmid, W., Cole, T.J., Blendy, J.A., Schütz, G.

“…A null mutation of the glucocorticoid receptor was generated by homologous recombination. Mutant newborn mice showed impaired lung development, hypertrophy of…”
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