Search Results - "Bleicher, Leo S."

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases by Paveley, Ross A, Mansour, Nuha R, Hallyburton, Irene, Bleicher, Leo S, Benn, Alex E, Mikic, Ivana, Guidi, Alessandra, Gilbert, Ian H, Hopkins, Andrew L, Bickle, Quentin D

“…Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting…”
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An exploratory study of combination buspirone and melatonin SR in Major Depressive Disorder (MDD): A possible role for neurogenesis in drug discovery by Fava, Maurizio, Targum, Steven D, Nierenberg, Andrew A, Bleicher, Leo S, Carter, Todd A, Wedel, Pamela C, Hen, René, Gage, Fred H, Barlow, Carrolee

“…Abstract We used in vitro neurogenesis-based human neural stem cell (hNSCs) assays and rodent in vivo behavioral assays to identify potential novel…”
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Enhanced utility of AI/ML methods during lead optimization by inclusion of 3D ligand information by Bleicher, Leo S., van Daelen, Ton, Honeycutt, J. Dana, Hassan, Moises, Chandrasekhar, Jayaraman, Shirley, William, Tsui, Vickie, Schmitz, Uli

“…AI/ML methods in drug discovery are maturing and their utility and impact is likely to permeate many aspects of drug discovery including lead finding and lead…”
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A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder by Targum, Steven D, Wedel, Pamela C, Robinson, Jill, Daniel, David G, Busner, Joan, Bleicher, Leo S, Rauh, Philip, Barlow, Carrolee

“…Abstract We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of…”
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A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist (S)-(−)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y) by Bleicher, Leo S, Cosford, Nicholas D. P, Herbaut, Audrey, McCallum, J. Stuart, McDonald, Ian A

“…An efficient, high-yielding synthetic procedure for the preparation of the novel neuronal acetylcholine-gated ion channel agonist…”
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Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists by Chua, Peter C., Nagasawa, Johnny Y., Bleicher, Leo S., Munoz, Benito, Schweiger, Edwin J., Tehrani, Lida, Anderson, Jeffrey J., Cramer, Merryl, Chung, Janice, Green, Mitchell D., King, Chris D., Reyes-Manalo, Grace, Cosford, Nicholas D.P.

“…Structure–activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency,…”
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A Novel Method for the Racemization of 5-Bromonicotine by Bleicher, Leo S, Cosford, Nicholas D. P

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