Search Results - "Bledsoe, Sharon"

Randall's plaque in stone formers originates in ascending thin limbs by Evan, Andrew P, Coe, Fredric L, Lingeman, James, Bledsoe, Sharon, Worcester, Elaine M

“…Randall's plaque, an attachment site over which calcium oxalate stones form, begins in the basement membranes of thin limbs of the loop of Henle. The mechanism…”
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Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease by Williams, James C., Borofsky, Michael S., Bledsoe, Sharon B., Evan, Andrew P., Coe, Fredric L., Worcester, Elaine M., Lingeman, James E.

“…Mechanisms of early stone retention in the kidney are under studied and poorly understood. To date attachment via Randall's plaque is the only widely accepted…”
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Sotatercept for anemia of myelofibrosis: a phase II investigator-initiated study by Bose, Prithviraj, Masarova, Lucia, Pemmaraju, Naveen, Bledsoe, Sharon D, Daver, Naval G, Jabbour, Elias J, Kadia, Tapan M, Estrov, Zeev, Kornblau, Steven M, Andreeff, Michael, Jain, Nitin, Cortes, Jorge E, Borthakur, Gautam, Alvarado, Yesid, Richie, Mary Ann, Dobbins, Mackenzie H, McCrackin, Selene A, Zhou, Lingsha, Pierce, Sherry A, Wang, Xuemei, Pike, Allison M, Garcia-Manero, Guillermo, Kantarjian, Hagop M, Verstovsek, Srdan

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A crystallin mutant cataract with mineral deposits by Minogue, Peter J., Gao, Junyuan, Mathias, Richard T., Williams, James C., Bledsoe, Sharon B., Sommer, Andre J., Beyer, Eric C., Berthoud, Viviana M.

“…Connexin mutant mice develop cataracts containing calcium precipitates. To test whether pathologic mineralization is a general mechanism contributing to the…”
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Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis by Williams, Jr, James C, Al-Awadi, Haider, Muthenini, Manognya, Bledsoe, Sharon B, El-Achkar, Tarek, Evan, Andrew P, Coe, Fredric, Lingeman, James E, Worcester, Elaine M

“…About 1 in 11 Americans will experience a kidney stone, but underlying causes remain obscure. The objective of the present study was to separate idiopathic…”
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Multimodal imaging reveals a unique autofluorescence signature of Randall’s plaque by Winfree, Seth, Weiler, Courtney, Bledsoe, Sharon B., Gardner, Tony, Sommer, André J., Evan, Andrew P., Lingeman, James E., Krambeck, Amy E., Worcester, Elaine M., El-Achkar, Tarek M., Williams, James C.

“…Kidney stones frequently develop as an overgrowth on Randall’s plaque (RP) which is formed in the papillary interstitium. The organic composition of RP is…”
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Human jackstone arms show a protein-rich, X-ray lucent core, suggesting that proteins drive their rapid and linear growth by Canela, Victor Hugo, Dzien, Cornelius, Bledsoe, Sharon B., Borofsky, Michael S., Boris, Ronald S., Lingeman, James E., El-Achkar, Tarek M., Williams, James C.

“…Jackstone calculi, having arms that extend out from the body of the stone, were first described over a century ago, but this morphology of stones has been…”
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Connexin Mutants Cause Cataracts Through Deposition of Apatite by Minogue, Peter J, Sommer, Andre J, Williams, Jr, James C, Bledsoe, Sharon B, Beyer, Eric C, Berthoud, Viviana M

“…Cataracts are lens opacities that are among the most common causes of blindness. It is commonly believed that cataracts develop through the accumulation of…”
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Collagen fibrils and cell nuclei are entrapped within Randall's plaques but not in CaOx matrix overgrowth: A microscopic inquiry into Randall's plaque stone pathogenesis by Canela, Victor Hugo, Bledsoe, Sharon B., Worcester, Elaine M., Lingeman, James E., El‐Achkar, Tarek M., Williams, James C.

“…Calcium oxalate (CaOx) stones can grow attached to the renal papillary calcification known as Randall's plaque. Although stone growth on Randall's plaque is a…”
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Randall's plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle by Evan, Andrew P, Lingeman, James E, Coe, Fredric L, Parks, Joan H, Bledsoe, Sharon B, Shao, Youzhi, Sommer, Andre J, Paterson, Ryan F, Kuo, Ramsay L, Grynpas, Marc

“…Our purpose here is to test the hypothesis that Randall's plaques, calcium phosphate deposits in kidneys of patients with calcium renal stones, arise in unique…”
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Mechanism of Formation of Human Calcium Oxalate Renal Stones on Randall's Plaque by Evan, Andrew P., Coe, Fredric L., Lingeman, James E., Shao, Youzhi, Sommer, Andre J., Bledsoe, Sharon B., Anderson, Jennifer C., Worcester, Elaine M.

“…Although calcium oxalate (CaOx) renal stones are known to grow attached to renal papillae, and specifically to regions of papillae that contain Randall's…”
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Label‐free imaging of non‐deparaffinized sections of the human kidney to determine tissue quality and signatures of disease by Sabo, Angela R., Winfree, Seth, Bledsoe, Sharon B., Phillips, Carrie L., Lingeman, James E., Eadon, Michael T., Williams, James C., El‐Achkar, Tarek M.

“…Label‐free fluorescence imaging of kidney sections can provide important morphological information, but its utility has not been tested in a histology…”
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Intra-tubular deposits, urine and stone composition are divergent in patients with ileostomy by Evan, Andrew P., Lingeman, James E., Coe, Fredric L., Bledsoe, Sharon B., Sommer, Andre J., Williams, James C., Krambeck, Amy E., Worcester, Elaine M.

“…Patients with ileostomy typically have recurrent renal stones and produce scanty, acidic, sodium-poor urine because of abnormally large enteric losses of water…”
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Renal histopathology and crystal deposits in patients with small bowel resection and calcium oxalate stone disease by Evan, Andrew P., Lingeman, James E., Worcester, Elaine M., Bledsoe, Sharon B., Sommer, Andre J., Williams, James C., Krambeck, Amy E., Philips, Carrie L., Coe, Fredric L.

“…We present here the anatomy and histopathology of kidneys from 11 patients with renal stones following small bowel resection, including 10 with Crohn's disease…”
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Demineralization and sectioning of human kidney stones: A molecular investigation revealing the spatial heterogeneity of the stone matrix by Canela, Victor Hugo, Bledsoe, Sharon B., Lingeman, James E., Gerber, Glenn, Worcester, Elaine M., El‐Achkar, Tarek M., Williams, James C.

“…The molecular mechanisms by which kidney stones grow are largely unknown. Organic molecules from the urine combine with mineral crystals to form stones, but…”
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A formal test of the hypothesis that idiopathic calcium oxalate stones grow on Randall’s plaque by Miller, Nicole L., Gillen, Daniel L., Williams, James C., Evan, Andrew P., Bledsoe, Sharon B., Coe, Fredric L., Worcester, Elaine M., Matlaga, Brian R., Munch, Larry C., Lingeman, James E.

“…OBJECTIVE To confirm that more than half of all idiopathic calcium oxalate (CaOx) stones grow on interstitial plaque, as CaOx stones can grow attached to…”
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P1025: A PILOT STUDY OF THE ANTI‐SLAMF7 MONOCLONAL ANTIBODY, ELOTUZUMAB, IN PATIENTS WITH MYELOFIBROSIS by Bose, Prithviraj, Masarova, Lucia, Pemmaraju, Naveen, Dobbins, Mackenzie, Jain, Nitin, Abbas, Hussein, Kornblau, Steven, Maiti, Abhishek, Veletic, Ivo, Manshouri, Taghi, Bledsoe, Sharon, Ann Richie, Mary, Hall‐Moore, Nakiuda, Zhou, Lingsha, Wang, Xuemei, Kantarjian, Hagop, Estrov, Zeev, Verstovsek, Srdan

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Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: Osteopontin localization by Evan, Andrew P., Coe, Fredric L., Rittling, Susan R., Bledsoe, Sharon M., Shao, Youzhi, Lingeman, James E., Worcester, Elaine M.

“…Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: Osteopontin localization. We have previously shown that interstitial…”
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Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones by Evan, Andrew E., Lingeman, James E., Coe, Fredric L., Miller, Nicole L., Bledsoe, Sharon B., Sommer, Andre J., Williams, James C., Shao, Youzhi, Worcester, Elaine M.

“…Using a combination of intra-operative digital photography and micro-biopsy we measured renal cortical and papillary changes in five patients with primary…”
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The Advantages of an Attenuated Total Internal Reflection Infrared Microspectroscopic Imaging Approach for Kidney Biopsy Analysis by Gulley-Stahl, Heather J., Bledsoe, Sharon B., Evan, Andrew P., Sommer, Andre J.

“…The benefits of an attenuated total reflection Fourier transform infrared (ATR-FTIR) imaging approach for kidney biopsy analysis are described. Biopsy sections…”
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