Search Results - "Bleckwehl, Tore"

Transcriptional and epigenetic control of germline competence and specification by Bleckwehl, Tore, Rada-Iglesias, Alvaro

“…•A complete exit of the naïve expression program is required for germline competence.•Germline competence is a transient property of the early…”
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The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo by Crispatzu, Giuliano, Rehimi, Rizwan, Pachano, Tomas, Bleckwehl, Tore, Cruz-Molina, Sara, Xiao, Cally, Mahabir, Esther, Bazzi, Hisham, Rada-Iglesias, Alvaro

“…Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that control the expression of major developmental genes. Before…”
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Enhancer-associated H3K4 methylation safeguards in vitro germline competence by Bleckwehl, Tore, Crispatzu, Giuliano, Schaaf, Kaitlin, Respuela, Patricia, Bartusel, Michaela, Benson, Laura, Clark, Stephen J., Dorighi, Kristel M., Barral, Antonio, Laugsch, Magdalena, van IJcken, Wilfred F. J., Manzanares, Miguel, Wysocka, Joanna, Reik, Wolf, Rada-Iglesias, Álvaro

“…Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial…”
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Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner by Hoeft, Konrad, Schaefer, Gideon J.L., Kim, Hyojin, Schumacher, David, Bleckwehl, Tore, Long, Qingqing, Klinkhammer, Barbara Mara, Peisker, Fabian, Koch, Lars, Nagai, James, Halder, Maurice, Ziegler, Susanne, Liehn, Elisa, Kuppe, Christoph, Kranz, Jennifer, Menzel, Sylvia, Costa, Ivan, Wahida, Adam, Boor, Peter, Schneider, Rebekka K., Hayat, Sikander, Kramann, Rafael

“…Fibrosis represents the common end stage of chronic organ injury independent of the initial insult, destroying tissue architecture and driving organ failure…”
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A paper-based, cell-free biosensor system for the detection of heavy metals and date rape drugs by Gräwe, Alexander, Dreyer, Anna, Vornholt, Tobias, Barteczko, Ursela, Buchholz, Luzia, Drews, Gila, Ho, Uyen Linh, Jackowski, Marta Eva, Kracht, Melissa, Lüders, Janina, Bleckwehl, Tore, Rositzka, Lukas, Ruwe, Matthias, Wittchen, Manuel, Lutter, Petra, Müller, Kristian, Kalinowski, Jörn

“…Biosensors have emerged as a valuable tool with high specificity and sensitivity for fast and reliable detection of hazardous substances in drinking water…”
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Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression by Li-Bao, Lin, Díaz-Díaz, Covadonga, Raiola, Morena, Sierra, Rocío, Temiño, Susana, Moya, Francisco J., Rodriguez-Perales, Sandra, Santos, Elisa, Giovinazzo, Giovanna, Bleckwehl, Tore, Rada-Iglesias, Álvaro, Spitz, Francois, Torres, Miguel

“…MYC plays various roles in pluripotent stem cells, including the promotion of somatic cell reprogramming to pluripotency, the regulation of cell competition…”
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Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells by Wang, Yuanming, Liu, Kaiwen Ivy, Sutrisnoh, Norfala-Aliah Binte, Srinivasan, Harini, Zhang, Junyi, Li, Jia, Zhang, Fan, Lalith, Charles Richard John, Xing, Heyun, Shanmugam, Raghuvaran, Foo, Jia Nee, Yeo, Hwee Ting, Ooi, Kean Hean, Bleckwehl, Tore, Par, Yi Yun Rachel, Lee, Shi Mun, Ismail, Nur Nadiah Binte, Sanwari, Nur Aidah Binti, Lee, Si Ting Vanessa, Lew, Jan, Tan, Meng How

“…While CRISPR-Cas systems hold tremendous potential for engineering the human genome, it is unclear how well each system performs against one another in both…”
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Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell immunoprofiling by Schreibing, Felix, Hannani, Monica T, Kim, Hyojin, Nagai, James S, Ticconi, Fabio, Fewings, Eleanor, Bleckwehl, Tore, Begemann, Matthias, Torow, Natalia, Kuppe, Christoph, Kurth, Ingo, Kranz, Jennifer, Frank, Dario, Anslinger, Teresa M, Ziegler, Patrick, Kraus, Thomas, Enczmann, Jürgen, Balz, Vera, Windhofer, Frank, Balfanz, Paul, Kurts, Christian, Marx, Gernot, Marx, Nikolaus, Dreher, Michael, Schneider, Rebekka K, Saez-Rodriguez, Julio, Costa, Ivan, Hayat, Sikander, Kramann, Rafael

“…SARS-CoV-2 infection results in varying disease severity, ranging from asymptomatic infection to severe illness. A detailed understanding of the immune…”
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Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs by Laugsch, Magdalena, Bartusel, Michaela, Rehimi, Rizwan, Alirzayeva, Hafiza, Karaolidou, Agathi, Crispatzu, Giuliano, Zentis, Peter, Nikolic, Milos, Bleckwehl, Tore, Kolovos, Petros, van Ijcken, Wilfred F.J., Šarić, Tomo, Koehler, Katrin, Frommolt, Peter, Lachlan, Katherine, Baptista, Julia, Rada-Iglesias, Alvaro

“…The pathological consequences of structural variants disrupting 3D genome organization can be difficult to elucidate in vivo due to differences in gene dosage…”
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Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness by Pachano, Tomas, Sánchez-Gaya, Víctor, Ealo, Thais, Mariner-Faulí, Maria, Bleckwehl, Tore, Asenjo, Helena G., Respuela, Patricia, Cruz-Molina, Sara, Muñoz-San Martín, María, Haro, Endika, van IJcken, Wilfred F. J., Landeira, David, Rada-Iglesias, Alvaro

“…CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being associated with ~70% of all gene promoters. CGIs control transcription…”
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Targeting immune–fibroblast cell communication in heart failure by Amrute, Junedh M., Luo, Xin, Penna, Vinay, Yang, Steven, Yamawaki, Tracy, Hayat, Sikander, Bredemeyer, Andrea, Jung, In-Hyuk, Kadyrov, Farid F., Heo, Gyu Seong, Venkatesan, Rajiu, Shi, Sally Yu, Parvathaneni, Alekhya, Koenig, Andrew L., Kuppe, Christoph, Baker, Candice, Luehmann, Hannah, Jones, Cameran, Kopecky, Benjamin, Zeng, Xue, Bleckwehl, Tore, Ma, Pan, Lee, Paul, Terada, Yuriko, Fu, Angela, Furtado, Milena, Kreisel, Daniel, Kovacs, Atilla, Stitziel, Nathan O., Jackson, Simon, Li, Chi-Ming, Liu, Yongjian, Rosenthal, Nadia A., Kramann, Rafael, Ason, Brandon, Lavine, Kory J.

“…Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction 1 , 2 . However, the molecular mechanisms driving immune–fibroblast cell…”
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