Search Results - "Bleck, Christopher K"

Dynamics in protein translation sustaining T cell preparedness by Wolf, Tobias, Jin, Wenjie, Zoppi, Giada, Vogel, Ian A., Akhmedov, Murodzhon, Bleck, Christopher K. E., Beltraminelli, Tim, Rieckmann, Jan C., Ramirez, Neftali J., Benevento, Marco, Notarbartolo, Samuele, Bumann, Dirk, Meissner, Felix, Grimbacher, Bodo, Mann, Matthias, Lanzavecchia, Antonio, Sallusto, Federica, Kwee, Ivo, Geiger, Roger

“…In response to pathogenic threats, naive T cells rapidly transition from a quiescent to an activated state, yet the underlying mechanisms are incompletely…”
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The unified myofibrillar matrix for force generation in muscle by Willingham, T. Bradley, Kim, Yuho, Lindberg, Eric, Bleck, Christopher K. E., Glancy, Brian

“…Human movement occurs through contraction of the basic unit of the muscle cell, the sarcomere. Sarcomeres have long been considered to be arranged end-to-end…”
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Immunity to commensal skin fungi promotes psoriasiform skin inflammation by Hurabielle, Charlotte, Link, Verena M., Bouladoux, Nicolas, Han, Seong-Ji, Merrill, Eric Dean, Lightfoot, Yaima L., Seto, Nickie, Bleck, Christopher K. E., Smelkinson, Margery, Harrison, Oliver J., Linehan, Jonathan L., Tamoutounour, Samira, Lionakis, Michail S., Kaplan, Mariana J., Nakajima, Saeko, Belkaid, Yasmine

“…Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell…”
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Emerging Pathogenic Unit of Vesicle-Cloaked Murine Norovirus Clusters is Resistant to Environmental Stresses and UV254 Disinfection by Zhang, Mengyang, Ghosh, Sourish, Kumar, Manish, Santiana, Marianita, Bleck, Christopher K. E, Chaimongkol, Natthawan, Altan-Bonnet, Nihal, Shuai, Danmeng

“…An individual virion was long believed to act as an independent infectious unit in virology, until the recent discovery of vesicle-cloaked virus clusters which…”
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Identification of evolutionarily conserved regulators of muscle mitochondrial network organization by Katti, Prasanna, Ajayi, Peter T., Aponte, Angel, Bleck, Christopher K. E., Glancy, Brian

“…Mitochondrial networks provide coordinated energy distribution throughout muscle cells. However, pathways specifying mitochondrial networks are incompletely…”
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Mitochondrial network configuration influences sarcomere and myosin filament structure in striated muscles by Katti, Prasanna, Hall, Alexander S., Parry, Hailey A., Ajayi, Peter T., Kim, Yuho, Willingham, T. Bradley, Bleck, Christopher K. E., Wen, Han, Glancy, Brian

“…Sustained muscle contraction occurs through interactions between actin and myosin filaments within sarcomeres and requires a constant supply of adenosine…”
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Kinesin-1 activity recorded in living cells with a precipitating dye by Angerani, Simona, Lindberg, Eric, Klena, Nikolai, Bleck, Christopher K. E., Aumeier, Charlotte, Winssinger, Nicolas

“…Kinesin-1 is a processive motor protein that uses ATP-derived energy to transport a variety of intracellular cargoes toward the cell periphery. The ability to…”
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Subcellular connectomic analyses of energy networks in striated muscle by Bleck, Christopher K. E., Kim, Yuho, Willingham, T. Bradley, Glancy, Brian

“…Mapping biological circuit connectivity has revolutionized our understanding of structure-function relationships. Although connectomic analyses have primarily…”
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Regulation of the evolutionarily conserved muscle myofibrillar matrix by cell type dependent and independent mechanisms by Ajayi, Peter T., Katti, Prasanna, Zhang, Yingfan, Willingham, T. Bradley, Sun, Ye, Bleck, Christopher K. E., Glancy, Brian

“…Skeletal muscles play a central role in human movement through forces transmitted by contraction of the sarcomere. We recently showed that mammalian sarcomeres…”
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Prazoles Targeting Tsg101 Inhibit Release of Epstein-Barr Virus following Reactivation from Latency by Mannemuddhu, Sai Sudha, Xu, Huanzhou, Bleck, Christopher K E, Tjandra, Nico, Carter, Carol, Bhaduri-McIntosh, Sumita

“…Epstein-Barr virus (EBV) is a ubiquitous herpesvirus responsible for several diseases, including cancers of lymphoid and epithelial cells. EBV cancers…”
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Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface by Garten, Matthias, Beck, Josh R., Roth, Robyn, Tenkova-Heuser, Tatyana, Heuser, John, Istvan, Eva S., Bleck, Christopher K. E., Goldberg, Daniel E., Zimmerberg, Joshua

“…The malaria parasite interfaces with its host erythrocyte (RBC) using a unique organelle, the parasitophorous vacuole (PV). The mechanism(s) are obscure by…”
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Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34 by Kasmapour, Bahram, Gronow, Achim, Bleck, Christopher K. E, Hong, Wanjin, Gutierrez, Maximiliano Gabriel

“…Phagosome maturation is an essential part of the innate and adaptive immune response. Although it is well established that several Ras-related proteins in…”
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The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology by Chiba, Yuta, He, Bing, Yoshizaki, Keigo, Rhodes, Craig, Ishijima, Muneaki, Bleck, Christopher K.E., Stempinski, Erin, Chu, Emily Y., Nakamura, Takashi, Iwamoto, Tsutomu, de Vega, Susana, Saito, Kan, Fukumoto, Satoshi, Yamada, Yoshihiko

“…The development of ectodermal organs, such as teeth, requires epithelial–mesenchymal interactions. Basic helix–loop–helix (bHLH) transcription factors regulate…”
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Composition and three-dimensional architecture of the dengue virus replication and assembly sites by Welsch, Sonja, Miller, Sven, Romero-Brey, Ines, Merz, Andreas, Bleck, Christopher K E, Walther, Paul, Fuller, Stephen D, Antony, Claude, Krijnse-Locker, Jacomine, Bartenschlager, Ralf

“…Positive-strand RNA viruses are known to rearrange cellular membranes to facilitate viral genome replication. The biogenesis and three-dimensional organization…”
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Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria by Anand, Paras K, Anand, Ellis, Bleck, Christopher K E, Anes, Elsa, Griffiths, Gareth

“…Exosomes are endosome-derived vesicles that are released when multi-vesicular bodies (MVBs) fuse with the plasma membrane. Exosomes released from…”
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Circulating exosomal microRNAs in acquired aplastic anemia and myelodysplastic syndromes by Giudice, Valentina, Banaszak, Lauren G, Gutierrez-Rodrigues, Fernanda, Kajigaya, Sachiko, Panjwani, Reema, Ibanez, Maria Del Pilar Fernandez, Rios, Olga, Bleck, Christopher K, Stempinski, Erin S, Raffo, Diego Quinones, Townsley, Danielle M, Young, Neal S

“…Exosomal microRNAs modulate cancer cell metabolism and the immune response. Specific exosomal microRNAs have been reported to be reliable biomarkers of several…”
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Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation by Chen, Zhe, Wang, Zong-Heng, Zhang, Guofeng, Bleck, Christopher K E, Chung, Dillon J, Madison, Grey P, Lindberg, Eric, Combs, Christian, Balaban, Robert S, Xu, Hong

“…Although mitochondrial DNA (mtDNA) is prone to accumulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly rare…”
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p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities by Li, Jie, Wang, Ping-yuan, Long, Nathaniel A., Zhuang, Jie, Springer, Danielle A., Zou, Jizhong, Lin, Yongshun, Bleck, Christopher K. E., Park, Ji-Hoon, Kang, Ju-Gyeong, Hwang, Paul M.

“…Doxorubicin is a widely used chemotherapeutic agent that causes dose-dependent cardiotoxicity in a subset of treated patients, but the genetic determinants of…”
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LRRK2 mediates tubulation and vesicle sorting from lysosomes by Bonet-Ponce, Luis, Beilina, Alexandra, Williamson, Chad D, Lindberg, Eric, Kluss, Jillian H, Saez-Atienzar, Sara, Landeck, Natalie, Kumaran, Ravindran, Mamais, Adamantios, Bleck, Christopher K E, Li, Yan, Cookson, Mark R

“…Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson's disease (PD). However, the biological functions of LRRK2 remain…”
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Long Prehensile Protrusions Can Facilitate Cancer Cell Invasion through the Basement Membrane by Nazari, Shayan S, Doyle, Andrew D, Bleck, Christopher K E, Yamada, Kenneth M

“…A basic process in cancer is the breaching of basement-membrane barriers to permit tissue invasion. Cancer cells can use proteases and physical mechanisms to…”
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