Search Results - "Bleakley, Brian J."

Integrated omics dissection of proteome dynamics during cardiac remodeling by Lau, Edward, Cao, Quan, Lam, Maggie P. Y., Wang, Jie, Ng, Dominic C. M., Bleakley, Brian J., Lee, Jessica M., Liem, David A., Wang, Ding, Hermjakob, Henning, Ping, Peipei

“…Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics…”
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation by Lam, Maggie P Y, Wang, Ding, Lau, Edward, Liem, David A, Kim, Allen K, Ng, Dominic C M, Liang, Xiangbo, Bleakley, Brian J, Liu, Chenguang, Tabaraki, Jason D, Cadeiras, Martin, Wang, Yibin, Deng, Mario C, Ping, Peipei

“…Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in…”
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A large dataset of protein dynamics in the mammalian heart proteome by Lau, Edward, Cao, Quan, Ng, Dominic C.M., Bleakley, Brian J., Dincer, T. Umut, Bot, Brian M., Wang, Ding, Liem, David A., Lam, Maggie P.Y., Ge, Junbo, Ping, Peipei

“…Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of…”
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Characterization of human plasma proteome dynamics using deuterium oxide by Wang, Ding, Liem, David A., Lau, Edward, Ng, Dominic C. M., Bleakley, Brian J., Cadeiras, Martin, Deng, Mario C., Lam, Maggie P. Y., Ping, Peipei

“…Purpose High‐throughput quantification of human protein turnover via in vivo administration of deuterium oxide (2H2O) is a powerful new approach to examine…”
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Abstract 353: Characterization Of Human Plasma Proteome Dynamics Using Deuterium Oxide by Wang, Ding, Liem, David A, Lau, Edward, Ng, Dominic C, Bleakley, Brian J, Cadeiras, Martin, Deng, Mario C, Lam, Maggie P, Ping, Peipei

“…Abstract only Protein turnover half-life is a critical determinant of cardiac homeostasis and can reveal previously unknown disease mechanisms. We recently…”
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Abstract 14080: Post-Transcriptional Regulation of Cardiac Protein Expression in Hypertrophy by Lau, Edward, Cao, Quan, Ng, Dominic C, Bleakley, Brian J, Lam, Maggie P, Ping, Peipei

“…IntroductionWhether gene expression is predominantly regulated by transcriptional or post-transcriptional processes is often debated. Pathological cardiac…”
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