Search Results - "Blazing, M. A."

In vivo gene transfer of nitric oxide synthase enhances vasomotor function in carotid arteries from normal and cholesterol-fed rabbits by CHANNON, K. M, HUSHENG QIAN, GEORGE, S. E, NEPLIOUEVA, V, BLAZING, M. A, OLMEZ, E, SHETTY, G. A, YOUNGBLOOD, S. A, PAWLOSKI, J, MCMAHON, T, STAMLER, J. S

“…The vascular endothelium is anatomically intact but functionally abnormal in preatherosclerotic states, and an early deficit in the bioavailability of nitric…”
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Adenoviral gene transfer of nitric oxide synthase : High level expression in human vascular cells by CHANNON, K. M, BLAZING, M. A, SHETTY, G. A, POTTS, K. E, GEORGE, S. E

“…Nitric oxide synthases (NOS) generate nitric oxide (NO), a second messenger with key regulatory roles. In the cardiovascular system, deficient endothelial NO…”
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Acute Host-Mediated Endothelial Injury After Adenoviral Gene Transfer in Normal Rabbit Arteries: Impact on Transgene Expression and Endothelial Function by Channon, Keith M, Qian, HuSheng, Youngblood, Scot A, Olmez, Ercument, Shetty, Geetha A, Neplioueva, Valentina, Blazing, Michael A, George, Samuel E

“…Acute injury after adenoviral vascular gene transfer remains incompletely characterized. Here, we describe the early response (<or=todays) in 52 New Zealand…”
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Atherosclerotic disease in non–insulin-dependent diabetes mellitus: Role of abnormal lipids and the place for lipid-altering therapies by Orloff, David G., Blazing, Michael A., O’Connor, Christopher M.

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The benefit of implementing a heart failure disease management program by Whellan, D J, Gaulden, L, Gattis, W A, Granger, B, Russell, S D, Blazing, M A, Cuffe, M S, O'Connor, C M

“…To handle the increasing complexity of congestive heart failure (CHF) care, several new models for the care of patients with CHF have been developed to replace…”
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Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes by Cannon, Christopher P., MD, Giugliano, Robert P., MD, SM, Blazing, Michael A., MD, Harrington, Robert A., MD, Peterson, John L., MD, Sisk, Christine McCrary, BS, Strony, John, MD, Musliner, Thomas A., MD, McCabe, Carolyn H., BS, Veltri, Enrico, MD, Braunwald, Eugene, MD, Califf, Robert M., MD

“…Background Reduction in low-density lipoprotein cholesterol (LDL-C) improves clinical outcomes in patients with chronic coronary artery disease and acute…”
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The A-to-Z Trial: Methods and rationale for a single trial investigating combined use of low-molecular-weight heparin with the glycoprotein IIb/IIIa inhibitor tirofiban and defining the efficacy of early aggressive simvastatin therapy by Blazing, Michael A., de Lemos, James A., Dyke, Christopher K., Califf, Robert M., Bilheimer, David, Braunwald, Eugene

“…Background The A-to-Z Trial is an ongoing international, multicenter, randomized study designed to investigate 2 issues concerning contemporary care of…”
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Lipid-protein interactions in reconstituted membranes containing acetylcholine receptor by Ellena, Jeffrey F, Blazing, Michael A, McNamee, Mark G

“…Functional membranes containing purified Torpedo californica acetylcholine receptor and dioleoylphosphatidylcholine (DOPC) were prepared by a cholate dialysis…”
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Vascular gene transfer by Channon, K. M., Blazing, M. A., George, S. E.

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Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure by Jiang, W, Alexander, J, Christopher, E, Kuchibhatla, M, Gaulden, L H, Cuffe, M S, Blazing, M A, Davenport, C, Califf, R M, Krishnan, R R, O'Connor, C M

“…Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes. To determine the…”
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Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome: The IMPROVE-IT Trial by Murphy, Sabina A, Cannon, Christopher P, Blazing, Michael A, Giugliano, Robert P, White, Jennifer A, Lokhnygina, Yuliya, Reist, Craig, Im, KyungAh, Bohula, Erin A, Isaza, Daniel, Lopez-Sendon, Jose, Dellborg, Mikael, Kher, Uma, Tershakovec, Andrew M, Braunwald, Eugene

“…Intensive low-density lipoprotein cholesterol therapy with ezetimibe/simvastatin in IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International…”
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Persistence of radiation (RT)-induced cardiac perfusion defects 3–5 years post RT by Yu, X., Zhou, S., Kahn, D., Hollis, D. R., Prosnitz, R. G., Hardenbergh, P. H., Blazing, M. A., Wong, T., Borges-Neto, S., Marks, L. B.

“…Abstract only…”
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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation by Su, Z, Blazing, M A, Fan, D, George, S E

“…The neuronal isoform of nitric oxide synthase (nNOS) requires calmodulin for nitric oxide producing activity. Calmodulin functions as a molecular switch,…”
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Neuronal Nitric-oxide Synthase Interaction with Calmodulin-Troponin C Chimeras by Gachhui, Ratan, Abu-Soud, Husam M., Ghoshà, Dipak K., Presta, Anthony, Blazing, Michael A., Mayer, Bernd, George, Samuel E., Stuehr, Dennis J.

“…Calmodulin (CaM) binding activates neuronal nitric-oxide synthase (nNOS) catalytic functions and also up-regulates electron transfer into its flavin and heme…”
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The health care burden of unstable angina by Kong, D F, Blazing, M A, O'Connor, C M

“…Worldwide, UA represents a significant allocation of resources. UA represents a syndrome where not only do many therapies exist, but considerable clinical…”
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Efficient adenoviral gene transfer to early venous bypass grafts: comparison with native vessels by Channon, K M, Fulton, G J, Gray, J L, Annex, B H, Shetty, G A, Blazing, M A, Peters, K G, Hagen, P O, George, S E

“…Gene therapy may provide new approaches to reduce vein graft failure following coronary or peripheral bypass surgery. The aim of this study was to investigate…”
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Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes by Cannon, Christopher P, Blazing, Michael A, Giugliano, Robert P, McCagg, Amy, White, Jennifer A, Theroux, Pierre, Darius, Harald, Lewis, Basil S, Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M, Ruzyllo, Witold, De Lucca, Paul, Im, KyungAh, Bohula, Erin A, Reist, Craig, Wiviott, Stephen D, Tershakovec, Andrew M, Musliner, Thomas A, Braunwald, Eugene, Califf, Robert M

“…In this trial, patients with an acute coronary syndrome within the previous 10 days were randomly assigned to simvastatin plus either ezetimibe or placebo. At…”
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Adenoviral gene transfer of nitric oxide synthase: High level expression in human vascular cells by Channon, Keith M., Blazing, Michael A., Shetty, Geetha A., Potts, Kevin E., George, Samuel E.

“…Objectives: Nitric oxide synthases (NOS) generate nitric oxide (NO), a second messenger with key regulatory roles. In the cardiovascular system, deficient…”
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Evidence supporting secondary prevention strategies by Blazing, Michael A, O’Connor, Christopher M

“…Currently 14 million individuals in the United States have coronary disease. Within the next 2 decades, this number is expected to increase to 21 million…”
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Early Intensive vs a Delayed Conservative Simvastatin Strategy in Patients With Acute Coronary Syndromes: Phase Z of the A to Z Trial by de Lemos, James A, Blazing, Michael A, Wiviott, Stephen D, Lewis, Eldrin F, Fox, Keith A. A, White, Harvey D, Rouleau, Jean-Lucien, Pedersen, Terje R, Gardner, Laura H, Mukherjee, Robin, Ramsey, Karen E, Palmisano, Joanne, Bilheimer, David W, Pfeffer, Marc A, Califf, Robert M, Braunwald, Eugene, for the A to Z Investigators

“…CONTEXT Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome (ACS) event affect clinical…”
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