Search Results - "Blazer, Levi L."

Small Molecule Protein-Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles by Blazer, Levi L, Neubig, Richard R

“…Protein-protein interactions are a crucial element in cellular function. The wealth of information currently available on intracellular-signaling pathways has…”
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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy by Chidiac, Rony, Abedin, Md, Macleod, Graham, Yang, Andy, Thibeault, Pierre E, Blazer, Levi L, Adams, Jarrett J, Zhang, Lingling, Roehrich, Heidi, Jo, Ha‐Neul, Seshagiri, Somasekar, Sidhu, Sachdev S, Junge, Harald J, Angers, Stephane

“…The FZD4:LRP5:TSPAN12 receptor complex is activated by the secreted protein Norrin in retinal endothelial cells and leads to βcatenin‐dependent formation of…”
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Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models by Newsted, Daniel, Banerjee, Sunandan, Watt, Kathleen, Nersesian, Sarah, Truesdell, Peter, Blazer, Levi L., Cardarelli, Lia, Adams, Jarrett J., Sidhu, Sachdev S., Craig, Andrew W.

“…Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. EOC is often diagnosed at late stages, with peritoneal metastases and…”
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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids by Alsaadi, Abdulkhaliq, Artibani, Mara, Hu, Zhiyuan, Wietek, Nina, Morotti, Matteo, Gonzalez, Laura Santana, Alazzam, Moiad, Jiang, Jason, Abdul, Beena, Soleymani majd, Hooman, Blazer, Levi L., Adams, Jarret, Silvestri, Francesca, Sidhu, Sachdev S., Brugge, Joan S., Ahmed, Ahmed Ashour

“…The study of fallopian tube (FT) function in health and disease has been hampered by limited knowledge of FT stem cells and lack of in vitro models of stem…”
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Regulators of G Protein Signaling Proteins as Targets for Drug Discovery by Sjögren, Benita, Blazer, Levi L., Neubig, Richard R.

“…Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological systems. Many clinically used drugs target GPCRs directly or target…”
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A T cell redirection platform for co-targeting dual antigens on solid tumors by Enderle, Leonie, Shalaby, Karim H, Gorelik, Maryna, Weiss, Alexander, Blazer, Levi L, Paduch, Marcin, Cardarelli, Lia, Kossiakoff, Anthony, Adams, Jarrett J, Sidhu, Sachdev S

“…In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named ual ntigen cell ngager (DATE), by…”
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Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification by Yang, Andy, Chidiac, Rony, Russo, Emma, Steenland, Hendrik, Pauli, Quinn, Bonin, Robert, Blazer, Levi L, Adams, Jarrett J, Sidhu, Sachdev S, Goeva, Aleksandrina, Salahpour, Ali, Angers, Stephane

“…The Wnt/β-catenin signaling governs anterior-posterior neural patterning during development. Current human pluripotent stem cell (hPSC) differentiation…”
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Antigen‐binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones by Bruce, Heather A., Singer, Alexander U., Blazer, Levi L., Luu, Khanh, Ploder, Lynda, Pavlenco, Alevtina, Kurinov, Igor, Adams, Jarrett J., Sidhu, Sachdev S.

“…It has been shown previously that a set of three modifications—termed S1, Crystal Kappa, and elbow—act synergistically to improve the crystallizability of an…”
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The role of the VPS4A-exosome pathway in the intrinsic egress route of a DNA-binding anticancer drug by CHEN, Vivien Y, POSADA, Maria M, BLAZER, Levi L, TONG ZHAO, ROSANIA, Gus R

“…This study investigates the subcellular pharmacokinetics of drug efflux in cancer cells and explores the role of the multivesicular body (MVB) in facilitating…”
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A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics by Sankar, Kannan, Trainor, Kyle, Blazer, Levi L., Adams, Jarrett J., Sidhu, Sachdev S., Day, Tyler, Meiering, Elizabeth, Maier, Johannes K. X.

“…There has been a remarkable increase in the number of biologics, especially monoclonal antibodies, in the market over the last decade. In addition to attaining…”
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A phage‐displayed single‐chain Fab library optimized for rapid production of single‐chain IgGs by Hanna, Rachel, Cardarelli, Lia, Patel, Nish, Blazer, Levi L., Adams, Jarrett J., Sidhu, Sachdev S.

“…Phage‐displayed synthetic antibody (Ab) repertoires have become a major source of affinity reagents for basic and clinical research. Specific Abs identified…”
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Engineered antigen‐binding fragments for enhanced crystallization of antibody:antigen complexes by Bruce, Heather A., Singer, Alexander U., Filippova, Ekaterina V., Blazer, Levi L., Adams, Jarrett J., Enderle, Leonie, Ben‐David, Moshe, Radley, Elizabeth H., Mao, Daniel Y. L., Pau, Victor, Orlicky, Stephen, Sicheri, Frank, Kurinov, Igor, Atwell, Shane, Kossiakoff, Anthony A., Sidhu, Sachdev S.

“…The atomic‐resolution structural information that X‐ray crystallography can provide on the binding interface between a Fab and its cognate antigen is highly…”
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Single-cell spatial transcriptomics reveals a dynamic control of metabolic zonation and liver regeneration by endothelial cell Wnt2 and Wnt9b by Hu, Shikai, Liu, Silvia, Bian, Yu, Poddar, Minakshi, Singh, Sucha, Cao, Catherine, McGaughey, Jackson, Bell, Aaron, Blazer, Levi L, Adams, Jarret J, Sidhu, Sachdev S, Angers, Stephane, Monga, Satdarshan P

“…The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains unclear despite an undisputed role of β-catenin. Using single-cell…”
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Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling by Griffiths, Samuel C, Tan, Jia, Wagner, Armin, Blazer, Levi L, Adams, Jarrett J, Srinivasan, Srisathya, Moghisaei, Shayan, Sidhu, Sachdev S, Siebold, Christian, Ho, Hsin-Yi Henry

“…The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes…”
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A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties by Pavlovic, Zvezdan, Adams, Jarrett J, Blazer, Levi L, Gakhal, Amandeep K, Jarvik, Nick, Steinhart, Zachary, Robitaille, Mélanie, Mascall, Keith, Pan, James, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S

“…Secreted Wnt ligands play a major role in the development and progression of many cancers by modulating signaling through cell-surface Frizzled receptors…”
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PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase by Blazer, Levi L., Lima-Fernandes, Evelyne, Gibson, Elisa, Eram, Mohammad S., Loppnau, Peter, Arrowsmith, Cheryl H., Schapira, Matthieu, Vedadi, Masoud

“…PR domain-containing protein 7 (PRDM7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. The two…”
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A Nanomolar-Potency Small Molecule Inhibitor of Regulator of G-Protein Signaling Proteins by Blazer, Levi L, Zhang, Haoming, Casey, Emma M, Husbands, Stephen M, Neubig, Richard R

“…Regulators of G-protein signaling (RGS) proteins are potent negative modulators of signal transduction through G-protein-coupled receptors. They function by…”
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Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins by Blazer, Levi L, Roman, David L, Chung, Alfred, Larsen, Martha J, Greedy, Benjamin M, Husbands, Stephen M, Neubig, Richard R

“…Regulators of G protein signaling (RGS) proteins are potent negative modulators of G protein signaling and have been proposed as potential targets for…”
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A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D by Blazer, Levi L, Li, Fengling, Kennedy, Steven, Zheng, Yujun George, Arrowsmith, Cheryl H, Vedadi, Masoud

“…BCDIN3D is an RNA-methyltransferase that O-methylates the 5' phosphate of RNA and regulates microRNA maturation. To discover small-molecule inhibitors of…”
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Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1 by Luan, Yepeng, Blazer, Levi L, Hu, Hao, Hajian, Taraneh, Zhang, Jing, Wu, Hong, Houliston, Scott, Arrowsmith, Cheryl H, Vedadi, Masoud, Zheng, Yujun George

“…The histone methyltransferase MLL1 has been linked to translocation-associated gene fusion in childhood leukemias and is an attractive drug target…”
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