Search Results - "Blaustein, Matias"

Whose shoulders is health research standing on? Determining the key actors and contents of the prevailing biomedical research agenda by Testoni, Federico E, García Carrillo, Mercedes, Gagnon, Marc-André, Rikap, Cecilia, Blaustein, Matías

“…Conflicts of interest in biomedical research can influence research results and drive research agendas away from public health priorities. Previous…”
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Yeast GPCR signaling reflects the fraction of occupied receptors, not the number by Bush, Alan, Vasen, Gustavo, Constantinou, Andreas, Dunayevich, Paula, Patop, Inés Lucía, Blaustein, Matías, Colman‐Lerner, Alejandro

“…According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor complex. Therefore, changes in receptor abundance should have…”
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Relationship between activity and stability: Design and characterization of stable variants of human frataxin by Castro, Ignacio Hugo, Bringas, Mauro, Doni, Davide, Noguera, Martin Ezequiel, Capece, Luciana, Aran, Martín, Blaustein, Matías, Costantini, Paola, Santos, Javier

“…The relationships between conformational dynamics, stability and protein function are not obvious. Frataxin (FXN) is an essential protein that forms part of a…”
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Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo by Charif, Santiago E, Luchelli, Luciana, Vila, Antonella, Blaustein, Matías, Igaz, Lionel M

“…TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral…”
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Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer by Suaya, Mariana, Sánchez, Gonzalo Manuel, Vila, Antonella, Amante, Analía, Cotarelo, María, García Carrillo, Mercedes, Blaustein, Matías

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic. Of…”
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Involvement of hnRNP A1 in the matrix metalloprotease-3-dependent regulation of Rac1 pre-mRNA splicing by Pelisch, Federico, Khauv, Davitte, Risso, Guillermo, Stallings-Mann, Melody, Blaustein, Matías, Quadrana, Leandro, Radisky, Derek C., Srebrow, Anabella

“…Rac1b is an alternatively spliced isoform of the small GTPase Rac1 that includes the 57‐nucleotide exon 3b. Rac1b was originally identified through its…”
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Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle by Risso, Guillermo, Pelisch, Federico, Pozzi, Berta, Mammi, Pablo, Blaustein, Matías, Colman-Lerner, Alejandro, Srebrow, Anabella

“…Akt/PKB is a key signaling molecule in higher eukaryotes and a crucial protein kinase in human health and disease. Phosphorylation, acetylation, and…”
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Modulation of the Akt pathway reveals a novel link with PERK/eIF2α, which is relevant during hypoxia by Blaustein, Matías, Pérez-Munizaga, Daniela, Sánchez, Manuel Alejandro, Urrutia, Carolina, Grande, Alicia, Risso, Guillermo, Srebrow, Anabella, Alfaro, Jennifer, Colman-Lerner, Alejandro

“…The unfolded protein response (UPR) and the Akt signaling pathway share several regulatory functions and have the capacity to determine cell outcome under…”
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Dynamic Distribution of ASIC1a Channels and Other Proteins within Cells Detected through Fractionation by Salinas Castellanos, Libia Catalina, Gatto, Rodolfo Gabriel, Menchón, Silvia Adriana, Blaustein, Matías, Uchitel, Osvaldo Daniel, Weissmann, Carina

“…Proteins in eukaryotic cells reside in different cell compartments. Many studies require the specific localization of proteins and the detection of any dynamic…”
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PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer by RIGGIO, Marina, POLO, Maria Laura, BLAUSTEIN, Matias, COLMAN-LERNER, Alejandro, LÜTHY, Isabel, LANARI, Claudia, NOVARO, Virginia

“…Using a model of medroxyprogesterone acetate (MPA)-induced mouse mammary tumors that transit through different stages of hormone dependence, we previously…”
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Akt/PKB: one kinase, many modifications by Risso, Guillermo, Blaustein, Matías, Pozzi, Berta, Mammi, Pablo, Srebrow, Anabella

“…Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the regulation of a plethora of cellular processes triggered by a wide…”
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SF2/ASF regulates proteomic diversity by affecting the balance between translation initiation mechanisms by Blaustein, Matías, Quadrana, Leandro, Risso, Guillermo, Mata, Manuel de la, Pelisch, Federico, Srebrow, Anabella

“…Post‐splicing activities have been described for a subset of shuttling serine/arginine‐rich splicing regulatory proteins, among them SF2/ASF. We showed that…”
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Tumor necrosis factor alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells by Levy, Carolina Schere, Slomiansky, Victoria, Gattelli, Albana, Nahmod, Karen, Pelisch, Federico, Blaustein, Matias, Srebrow, Anabella, Coso, Omar A., Kordon, Edith C.

“…It has been reported that expression of tumor necrosis factor superfamily members occur at the onset of the mammary gland post‐lactational involution. One of…”
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Cross-talk between signaling pathways regulates alternative splicing: a novel role for JNK by Pelisch, Federico, Blaustein, Matías, Kornblihtt, Alberto R, Srebrow, Anabella

“…The regulation of alternative splicing by extracellular signals represents a key event in the control of gene expression. There is increasing evidence showing…”
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What about Health Education? Hegemony, paradigms in tension and alternatives by Blaustein, Matías, Garelli, Fernando Miguel

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Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells by Alló, Mariano, Agirre, Eneritz, Bessonov, Sergey, Bertucci, Paola, Acuña, Luciana Gómez, Buggiano, Valeria, Bellora, Nicolás, Singh, Babita, Petrillo, Ezequiel, Blaustein, Matías, Miñana, Belén, Dujardin, Gwendal, Pozzi, Berta, Pelisch, Federico, Bechara, Elías, Agafonov, Dmitry E., Srebrow, Anabella, Lührmann, Reinhard, Valcárcel, Juan, Eyras, Eduardo, Kornblihtt, Alberto R.

“…Significance Argonaute proteins are well characterized factors in posttranscriptional gene silencing, the process by which small RNAs trigger mRNA degradation…”
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DNA Damage Regulates Alternative Splicing through Inhibition of RNA Polymerase II Elongation by Muñoz, Manuel J., Santangelo, M. Soledad Pérez, Paronetto, Maria P., de la Mata, Manuel, Pelisch, Federico, Boireau, Stéphanie, Glover-Cutter, Kira, Ben-Dov, Claudia, Blaustein, Matías, Lozano, Juan J., Bird, Gregory, Bentley, David, Bertrand, Edouard, Kornblihtt, Alberto R.

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Author Correction: A new tool to sense pH changes at the neuromuscular junction synaptic cleft by Blaustein, Matías, Wirth, Sonia, Saldaña, Gustavo, Piantanida, Ana Paula, Bogetti, María Eugenia, Martin, María Eugenia, Colman-Lerner, Alejandro, Uchitel, Osvaldo D.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Correction: Whose shoulders is health research standing on? Determining the key actors and contents of the prevailing biomedical research agenda by Testoni, Federico E, Carrillo, Mercedes García, Gagnon, Marc-André, Rikap, Cecilia, Blaustein, Matías

“…[This corrects the article DOI: 10.1371/journal.pone.0249661.]…”
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A Slow RNA Polymerase II Affects Alternative Splicing In Vivo by de la Mata, Manuel, Alonso, Claudio R, Kadener, Sebastián, Fededa, Juan P, Blaustein, Matı́as, Pelisch, Federico, Cramer, Paula, Bentley, David, Kornblihtt, Alberto R

“…Changes in promoter structure and occupation have been shown to modify the splicing pattern of several genes, evidencing a coupling between transcription and…”
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