Search Results - "Blatt, Katharina"

Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy by Focke-Tejkl, Margarete, PhD, Weber, Milena, MSc, Niespodziana, Katarzyna, PhD, Neubauer, Angela, PhD, Huber, Hans, PhD, Henning, Rainer, PhD, Stegfellner, Gottfried, MSc, Maderegger, Bernhard, PhD, Hauer, Martina, MSc, Stolz, Frank, PhD, Niederberger, Verena, MD, Marth, Katharina, MD, Eckl-Dorna, Julia, MD, PhD, Weiss, Richard, PhD, Thalhamer, Josef, PhD, Blatt, Katharina, MSc, Valent, Peter, MD, Valenta, Rudolf, MD

“…Background Grass pollen is one of the most important sources of respiratory allergies worldwide. Objective This study describes the development of a grass…”
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Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia by Herrmann, Harald, Sadovnik, Irina, Cerny-Reiterer, Sabine, Rülicke, Thomas, Stefanzl, Gabriele, Willmann, Michael, Hoermann, Gregor, Bilban, Martin, Blatt, Katharina, Herndlhofer, Susanne, Mayerhofer, Matthias, Streubel, Berthold, Sperr, Wolfgang R., Holyoake, Tessa L., Mannhalter, Christine, Valent, Peter

“…Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are…”
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Identification of a leukemia-initiating stem cell in human mast cell leukemia by Eisenwort, Gregor, Sadovnik, Irina, Schwaab, Juliana, Jawhar, Mohamad, Keller, Alexandra, Stefanzl, Gabriele, Berger, Daniela, Blatt, Katharina, Hoermann, Gregor, Bilban, Martin, Willmann, Michael, Winding, Christiana, Sperr, Wolfgang R., Arock, Michel, Rülicke, Thomas, Reiter, Andreas, Valent, Peter

“…Mast cell leukemia (MCL) is a highly fatal malignancy characterized by devastating expansion of immature mast cells in various organs. Although considered a…”
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Expression of CD25 on leukemic stem cells in BCR-ABL1+ CML: Potential diagnostic value and functional implications by Sadovnik, Irina, Herrmann, Harald, Eisenwort, Gregor, Blatt, Katharina, Hoermann, Gregor, Mueller, Niklas, Sperr, Wolfgang R, Valent, Peter

“…Chronic myeloid leukemia (CML) is a stem cell–derived leukemia in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein…”
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Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML by Sadovnik, Irina, Hoelbl-Kovacic, Andrea, Herrmann, Harald, Eisenwort, Gregor, Cerny-Reiterer, Sabine, Warsch, Wolfgang, Hoermann, Gregor, Greiner, Georg, Blatt, Katharina, Peter, Barbara, Stefanzl, Gabriele, Berger, Daniela, Bilban, Martin, Herndlhofer, Susanne, Sill, Heinz, Sperr, Wolfgang R, Streubel, Berthold, Mannhalter, Christine, Holyoake, Tessa L, Sexl, Veronika, Valent, Peter

“…In chronic myelogenous leukemia (CML), leukemic stem cells (LSC) represent a critical target of therapy. However, little is known about markers and targets…”
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Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy by Zieglmayer, Petra, Focke-Tejkl, Margarete, Schmutz, René, Lemell, Patrick, Zieglmayer, René, Weber, Milena, Kiss, Renata, Blatt, Katharina, Valent, Peter, Stolz, Frank, Huber, Hans, Neubauer, Angela, Knoll, Anette, Horak, Friedrich, Henning, Rainer, Valenta, Rudolf

“…We have developed a recombinant B cell epitope-based vaccine (BM32) for allergen-specific immunotherapy (AIT) of grass pollen allergy. The vaccine contains…”
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A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection by Saleh, Rosine, Wedeh, Ghaith, Herrmann, Harald, Bibi, Siham, Cerny-Reiterer, Sabine, Sadovnik, Irina, Blatt, Katharina, Hadzijusufovic, Emir, Jeanningros, Sylvie, Blanc, Catherine, Legarff-Tavernier, Magali, Chapiro, Elise, Nguyen-Khac, Florence, Subra, Frédéric, Bonnemye, Patrick, Dubreuil, Patrice, Desplat, Vanessa, Merle-Béral, Hélène, Willmann, Michael, Rülicke, Thomas, Valent, Peter, Arock, Michel

“…In systemic mastocytosis (SM), clinical problems arise from factor-independent proliferation of mast cells (MCs) and the increased release of mediators by MCs,…”
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Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy by Chen, Kuan-Wei, PhD, Blatt, Katharina, MSc, Thomas, Wayne R., PhD, Swoboda, Ines, PhD, Valent, Peter, MD, Valenta, Rudolf, MD, Vrtala, Susanne, PhD

“…Background More than 50% of allergic patients have house dust mite (HDM) allergy. Group 1 and 2 allergens are the major HDM allergens. Objective We sought to…”
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Phenotyping and Target Expression Profiling of CD34+/CD38− and CD34+/CD38+ Stem- and Progenitor cells in Acute Lymphoblastic Leukemia by Blatt, Katharina, Menzl, Ingeborg, Eisenwort, Gregor, Cerny-Reiterer, Sabine, Herrmann, Harald, Herndlhofer, Susanne, Stefanzl, Gabriele, Sadovnik, Irina, Berger, Daniela, Keller, Alexandra, Hauswirth, Alexander, Hoermann, Gregor, Willmann, Michael, Rülicke, Thomas, Sill, Heinz, Sperr, Wolfgang R., Mannhalter, Christine, Melo, Junia V., Jäger, Ulrich, Sexl, Veronika, Valent, Peter

“…Leukemic stem cells (LSCs) are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and…”
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Combined targeting of STAT3 and STAT5: a novel approach to overcome drug resistance in chronic myeloid leukemia by Gleixner, Karoline V, Schneeweiss, Mathias, Eisenwort, Gregor, Berger, Daniela, Herrmann, Harald, Blatt, Katharina, Greiner, Georg, Byrgazov, Konstantin, Hoermann, Gregor, Konopleva, Marina, Waliul, Islam, Cumaraswamy, Abbarna A, Gunning, Patrick T, Maeda, Hiroshi, Moriggl, Richard, Deininger, Michael, Lion, Thomas, Andreeff, Michael, Valent, Peter

“…In chronic myeloid leukemia, resistance against BCR-ABL1 tyrosine kinase inhibitors can develop because of mutations, activation of additional pro-oncogenic…”
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The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis by Schneeweiss, Mathias, Peter, Barbara, Bibi, Siham, Eisenwort, Gregor, Smiljkovic, Dubravka, Blatt, Katharina, Jawhar, Mohamad, Berger, Daniela, Stefanzl, Gabriele, Herndlhofer, Susanne, Greiner, Georg, Hoermann, Gregor, Hadzijusufovic, Emir, Gleixner, Karoline V, Bettelheim, Peter, Geissler, Klaus, Sperr, Wolfgang R, Reiter, Andreas, Arock, Michel, Valent, Peter

“…Systemic mastocytosis is a complex disease defined by abnormal growth and accumulation of neoplastic mast cells in various organs. Most patients exhibit a…”
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Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments by Campana, Raffaela, PhD, Moritz, Katharina, MD, Marth, Katharina, MD, Neubauer, Angela, PhD, Huber, Hans, PhD, Henning, Rainer, PhD, Blatt, Katharina, PhD, Hoermann, Gregor, MD, PhD, Brodie, Tess M., PhD, Kaider, Alexandra, MSc, Valent, Peter, MD, Sallusto, Federica, PhD, Wöhrl, Stefan, MD, MSc, Valenta, Rudolf, MD

“…Background Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE…”
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Molecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen by Resch, Yvonne, Blatt, Katharina, Malkus, Ursula, Fercher, Christian, Swoboda, Ines, Focke-Tejkl, Margit, Chen, Kuan-Wei, Seiberler, Susanne, Mittermann, Irene, Lupinek, Christian, Rodriguez-Dominguez, Azahara, Zieglmayer, Petra, Zieglmayer, René, Keller, Walter, Krzyzanek, Vladislav, Valent, Peter, Valenta, Rudolf, Vrtala, Susanne

“…The house dust mite (HDM) allergen Der p 18 belongs to the glycoside hydrolase family 18 chitinases. The relevance of Der p 18 for house dust mite allergic…”
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Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5 by Focke-Tejkl, Margarete, PhD, Campana, Raffaela, PhD, Reininger, Renate, PhD, Lupinek, Christian, MD, Blatt, Katharina, MSc, Valent, Peter, MD, Pavkov-Keller, Tea, PhD, Keller, Walter, PhD, Valenta, Rudolf, MD

“…Background The major timothy grass pollen allergen Phl p 5 belongs to the most potent allergens involved in hay fever and asthma. Objective This study…”
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Synergistic growth-inhibitory effects of ponatinib and midostaurin (PKC412) on neoplastic mast cells carrying KIT D816V by Gleixner, Karoline V, Peter, Barbara, Blatt, Katharina, Suppan, Verena, Reiter, Andreas, Radia, Deepti, Hadzijusufovic, Emir, Valent, Peter

“…Patients with advanced systemic mastocytosis, including mast cell leukemia, have a poor prognosis. In these patients, neoplastic mast cells usually harbor the…”
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The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia by Karlic, Heidrun, Herrmann, Harald, Varga, Franz, Thaler, Roman, Reitermaier, Rene, Spitzer, Silvia, Ghanim, Viviane, Blatt, Katharina, Sperr, Wolfgang R, Valent, Peter, Pfeilstöcker, Michael

“…Abstract Disordered stem cell epigenetics and apoptosis-regulating mechanisms contribute essentially to the pathogenesis of myelodysplastic syndromes (MDS) and…”
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Antibody conjugates bispecific for intercellular adhesion molecule 1 and allergen prevent migration of allergens through respiratory epithelial cell layers by Madritsch, Christoph, PhD, Eckl-Dorna, Julia, MD, PhD, Blatt, Katharina, PhD, Ellinger, Isabella, PhD, Kundi, Michael, MD, PhD, Niederberger, Verena, MD, Valent, Peter, MD, Valenta, Rudolf, MD, Flicker, Sabine, PhD

“…In a subsequent series of experiments, we demonstrated that P2/ICAM1 can prevent the apical-to-basolateral penetration of Phl p 2 but not of the birch pollen…”
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CD34+/CD38− stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin by HERRMANN, Harald, CERNY-REITERER, Sabine, SCHWARZINGER, Ilse, SPERR, Wolfgang R, VALENT, Peter, GLEIXNER, Karoline V, BLATT, Katharina, HERNDLHOFER, Susanne, RABITSCH, Werner, JÄGER, Eva, MITTERBAUER-HOHENDANNER, Gerlinde, STREUBEL, Berthold, SELZER, Edgar

“…CD33 is a well-known stem cell target in acute myeloid leukemia. So far, however, little is known about expression of CD33 on leukemic stem cells in chronic…”
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The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils by Blatt, Katharina, Herrmann, Harald, Mirkina, Irina, Hadzijusufovic, Emir, Peter, Barbara, Strommer, Sabine, Hoermann, Gregor, Mayerhofer, Matthias, Hoetzenecker, Konrad, Klepetko, Walter, Ghanim, Viviane, Marth, Katharina, Füreder, Thorsten, Wacheck, Volker, Valenta, Rudolf, Valent, Peter

“…The phosphoinositide 3-kinase (PI3-kinase) and the mammalian target of rapamycin (mTOR) are two major signaling molecules involved in growth and activation of…”
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A target-disease network model of second-generation BCR-ABL inhibitor action in Ph+ ALL by Rix, Uwe, Colinge, Jacques, Blatt, Katharina, Gridling, Manuela, Remsing Rix, Lily L, Parapatics, Katja, Cerny-Reiterer, Sabine, Burkard, Thomas R, Jäger, Ulrich, Melo, Junia V, Bennett, Keiryn L, Valent, Peter, Superti-Furga, Giulio

“…Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is in part driven by the tyrosine kinase bcr-abl, but imatinib does not produce…”
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