Search Results - "Blasco, Maria"

Hallmarks of aging: An expanding universe by López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido

“…Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally…”
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Telomere-driven diseases and telomere-targeting therapies by Martínez, Paula, Blasco, Maria A

“…Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's lifetime. Telomere shortening is proposed to be a primary molecular…”
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A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division by Rocheteau, Pierre, Gayraud-Morel, Barbara, Siegl-Cachedenier, Irene, Blasco, Maria A., Tajbakhsh, Shahragim

“…Satellite cells are adult skeletal muscle stem cells that are quiescent and constitute a poorly defined heterogeneous population. Using transgenic Tg:Pax7-nGFP…”
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Telomere length, stem cells and aging by Blasco, Maria A

“…Telomere shortening occurs concomitant with organismal aging, and it is accelerated in the context of human diseases associated with mutations in telomerase,…”
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The Hallmarks of Aging by López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido

“…Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration…”
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Telomere shortening rate predicts species life span by Whittemore, Kurt, Vera, Elsa, Martínez-Nevado, Eva, Sanpera, Carola, Blasco, Maria A.

“…Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a persistent DNA…”
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The common biology of cancer and ageing by Finkel, Toren, Serrano, Manuel, Blasco, Maria A

“…At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for this improbable union can actually be traced back to a sequence of…”
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Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II by Blasco, Maria A, Schoeftner, Stefan

“…Mammalian telomeres consist of non-coding TTAGGG repeats that are bound by the multi-protein complex 'shelterin', thus protecting chromosome ends from DNA…”
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Heart-Breaking Telomeres by Martínez, Paula, Blasco, Maria A

“…Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Accumulation of critically short telomeres is proposed to be…”
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Replicating through telomeres: a means to an end by Martínez, Paula, Blasco, Maria A.

“…•Telomeric DNA is repetitive and heterochromatic, hindering the replication machinery.•Telomeric DNA also forms secondary structures that hinder the…”
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Telomeres and human disease: ageing, cancer and beyond by Blasco, Maria A

“…Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are…”
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Gender differences in suicidal behavior in adolescents and young adults: systematic review and meta-analysis of longitudinal studies by Miranda-Mendizabal, Andrea, Castellví, Pere, Parés-Badell, Oleguer, Alayo, Itxaso, Almenara, José, Alonso, Iciar, Blasco, Maria Jesús, Cebrià, Annabel, Gabilondo, Andrea, Gili, Margalida, Lagares, Carolina, Piqueras, José Antonio, Rodríguez-Jiménez, Tiscar, Rodríguez-Marín, Jesús, Roca, Miquel, Soto-Sanz, Victoria, Vilagut, Gemma, Alonso, Jordi

“…Objectives To assess the association between gender and suicide attempt/death and identify gender-specific risk/protective factors in adolescents/young adults…”
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Mice with hyper-long telomeres show less metabolic aging and longer lifespans by Muñoz-Lorente, Miguel A., Cano-Martin, Alba C., Blasco, Maria A.

“…Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans. In the past, we generated mouse embryonic (ES) cells with longer…”
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Telomerase at the intersection of cancer and aging by Bernardes de Jesus, Bruno, Blasco, Maria A

“…Highlights • Telomere dysfunction is a primary cause of aging. • Telomerase dysfunction impairs tissue homeostasis. • Telomerase activation could act as an…”
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A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs by Schoeftner, Stefan, Blasco, Maria A

“…Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it…”
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Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction by Povedano, Juan M., Martinez, Paula, Flores, Juana M., Mulero, Francisca, Blasco, Maria A.

“…Idiopathic pulmonary fibrosis (IPF) is a degenerative disease of the lungs with an average survival post-diagnosis of 2–3 years. New therapeutic targets and…”
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Tissue damage and senescence provide critical signals for cellular reprogramming in vivo by Mosteiro, Lluc, Pantoja, Cristina, Alcazar, Noelia, Marión, Rosa M., Chondronasiou, Dafni, Rovira, Miguel, Fernandez-Marcos, Pablo J., Muñoz-Martin, Maribel, Blanco-Aparicio, Carmen, Pastor, Joaquin, Gómez-López, Gonzalo, De Martino, Alba, Blasco, Maria A., Abad, María, Serrano, Manuel

“…Reprogramming of differentiated cells into pluripotent cells can occur in vivo, but the mechanisms involved remain to be elucidated. Senescence is a cellular…”
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AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis by Sánchez-Vázquez, Raúl, Martínez, Paula, Blasco, Maria A

“…The telomere-bound shelterin complex is essential for chromosome-end protection and genomic stability. Little is known on the regulation of shelterin…”
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The Ink4/Arf locus is a barrier for iPS cell reprogramming by Serrano, Manuel, Li, Han, Collado, Manuel, Blasco, Maria A, Cañamero, Marta, Ortega, Sagrario, Strati, Katerina, Villasante, Aranzazu

“…The mechanisms involved in the reprogramming of differentiated cells into induced pluripotent stem (iPS) cells by the three transcription factors Oct4 (also…”
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Cellular Senescence in Cancer and Aging by Collado, Manuel, Blasco, Maria A., Serrano, Manuel

“…Cellular senescence, a state of irreversible growth arrest, can be triggered by multiple mechanisms including telomere shortening, the epigenetic derepression…”
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