Search Results - "Blasco, María A."

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins by Blasco, María A, Martínez, Paula

“…Key Points Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence bound by a specialized six-protein complex known as shelterin, which has…”
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The epigenetic regulation of mammalian telomeres by Blasco, María A

“…Increasing evidence indicates that chromatin modifications are important regulators of mammalian telomeres. Telomeres provide well studied paradigms of…”
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POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia by Ramsay, Andrew J, Quesada, Víctor, Foronda, Miguel, Conde, Laura, Martínez-Trillos, Alejandra, Villamor, Neus, Rodríguez, David, Kwarciak, Agnieszka, Garabaya, Cecilia, Gallardo, Mercedes, López-Guerra, Mónica, López-Guillermo, Armando, Puente, Xose S, Blasco, María A, Campo, Elías, López-Otín, Carlos

“…Carlos López-Otín and colleagues report recurrent mutations in POT1 in chronic lymphocytic leukemia. This is the first member of the telomeric shelterin…”
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The longest telomeres: a general signature of adult stem cell compartments by Flores, Ignacio, Canela, Andres, Vera, Elsa, Tejera, Agueda, Cotsarelis, George, Blasco, María A

“…Identification of adult stem cells and their location (niches) is of great relevance for regenerative medicine. However, stem cell niches are still poorly…”
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Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres by Blasco, María A, García-Cao, Marta, Benetti, Roberta

“…Mammalian telomeres have epigenetic marks of constitutive heterochromatin. Here, we study the impact of telomere length on the maintenance of heterochromatin…”
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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination by Benetti, Roberta, Gonzalo, Susana, Jaco, Isabel, Schotta, Gunnar, Klatt, Peter, Jenuwein, Thomas, Blasco, María A

“…Mammalian telomeres have heterochromatic features, including trimethylated histone H3 at lysine 9 (H3K9me3) and trimethylated histone H4 at lysine 20…”
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Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior by Flores, Ignacio, Cayuela, María L, Blasco, María A

“…A key process in organ homeostasis is the mobilization of stem cells out of their niches. We show through analysis of mouse models that telomere length, as…”
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High-throughput telomere length quantification by FISH and its application to human population studies by Canela, Andrés, Vera, Elsa, Klatt, Peter, Blasco, María A

“…A major limitation of studies of the relevance of telomere length to cancer and age-related diseases in human populations and to the development of…”
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Leukocyte telomere length in patients with schizophrenia and related disorders: a meta-analysis of case-control studies by Ayora, Miriam, Fraguas, David, Abregú-Crespo, Renzo, Recio, Sandra, Blasco, María A., Moises, Ana, Derevyanko, Aksinya, Arango, Celso, Díaz-Caneja, Covadonga M.

“…Context Telomere length may serve as a biomarker of cellular aging. The literature assessing telomere length in schizophrenia contains conflicting results…”
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Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study by Fernández-Alvira, Juan M, Fuster, Valentin, Dorado, Beatriz, Soberón, Nora, Flores, Ignacio, Gallardo, Mercedes, Pocock, Stuart, Blasco, María A, Andrés, Vicente

“…Leucocyte telomere length (LTL) shortening is associated with cardiovascular ischemic events and mortality in humans, but data on its association with…”
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Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes by Martínez-Balsalobre, Elena, García-Castillo, Jesús, García-Moreno, Diana, Naranjo-Sánchez, Elena, Fernández-Lajarín, Miriam, Blasco, María A., Alcaraz-Pérez, Francisca, Mulero, Victoriano, Cayuela, María L.

“…Telomerase RNA ( TERC ) has a noncanonical function in myelopoiesis binding to a consensus DNA binding sequence and attracting RNA polymerase II (RNA Pol II),…”
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Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis by Ferron, Sacri R, Marques-Torrejon, M. Angeles, Mira, Helena, Flores, Ignacio, Taylor, Kerrie, Blasco, Maria A, Farinas, Isabel

“…Proliferation in the subependymal zone (SEZ) and neurogenesis in the olfactory bulb decline in the forebrain of telomerase-deficient mice. The present work…”
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Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion by Ganuza, Miguel, Sáiz-Ladera, Cristina, Cañamero, Marta, Gómez, Gonzalo, Schneider, Ralph, Blasco, María A, Pisano, David, Paramio, Jesús M, Santamaría, David, Barbacid, Mariano

“…Cyclin‐dependent kinase (Cdk)7, the catalytic subunit of the Cdk‐activating kinase (CAK) complex has been implicated in the control of cell cycle progression…”
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Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3 by Fuentes-Fayos, Antonio C, Vázquez-Borrego, Mari C, Jiménez-Vacas, Juan M, Bejarano, Leire, Pedraza-Arévalo, Sergio, L-López, Fernando, Blanco-Acevedo, Cristóbal, Sánchez-Sánchez, Rafael, Reyes, Oscar, Ventura, Sebastián, Solivera, Juan, Breunig, Joshua J, Blasco, María A, Gahete, Manuel D, Castaño, Justo P, Luque, Raúl M

“…Glioblastomas remain the deadliest brain tumour, with a dismal ∼12-16-month survival from diagnosis. Therefore, identification of new diagnostic, prognostic…”
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Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres by Remeseiro, Silvia, Cuadrado, Ana, Carretero, María, Martínez, Paula, Drosopoulos, William C, Cañamero, Marta, Schildkraut, Carl L, Blasco, María A, Losada, Ana

“…Cohesin is a protein complex originally identified for its role in sister chromatid cohesion, although increasing evidence portrays it also as a major…”
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Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects by Landa, Iñigo, Thornton, Caitlin E M, Xu, Bin, Haase, Jacob, Krishnamoorthy, Gnana P, Hao, Jingzhu, Knauf, Jeffrey A, Herbert, Zachary T, Martínez, Paula, Blasco, María A, Ghossein, Ronald, Fagin, James A

“…Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a noncoding region. TERT…”
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Telomere Length Defines the Cardiomyocyte Differentiation Potency of Mouse Induced Pluripotent Stem Cells by Aguado, Tania, Gutiérrez, Francisco J., Aix, Esther, Schneider, Ralph P., Giovinazzo, Giovanna, Blasco, María A., Flores, Ignacio

“…Induced pluripotent stem cells (iPSCs) can be differentiated in vitro and in vivo to all cardiovascular lineages and are therefore a promising cell source for…”
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Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice by Sanz-Ros, Jorge, Romero-García, Nekane, Mas-Bargues, Cristina, Monleón, Daniel, Gordevicius, Juozas, Brooke, Robert T., Dromant, Mar, Díaz, Ana, Derevyanko, Aksinya, Guío-Carrión, Ana, Román-Domínguez, Aurora, Inglés, Marta, Blasco, María A., Horvath, Steve, Viña, Jose, Borrás, Consuelo

“…Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes associated with aging and…”
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DNA methyltransferases control telomere length and telomere recombination in mammalian cells by Blasco, María A, Gonzalo, Susana, Jaco, Isabel, Fraga, Mario F, Chen, Taiping, Li, En, Esteller, Manel

“…Here, we describe a role for mammalian DNA methyltransferases (DNMTs) in telomere length control. Mouse embryonic stem (ES) cells genetically deficient for…”
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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis by Blanco, Raquel, Muñoz, Purificación, Flores, Juana M, Klatt, Peter, Blasco, María A

“…TRF2 is a telomere-binding protein with roles in telomere protection and telomere-length regulation. The fact that TRF2 is up-regulated in some human tumors…”
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