Search Results - "Blanton, S."

Regulatory Mechanisms through RNA Conformational Switching and Dynamics by Bevilacqua, Philip C., Tolbert, Blanton S.

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IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex by Davila-Calderon, Jesse, Patwardhan, Neeraj N., Chiu, Liang-Yuan, Sugarman, Andrew, Cai, Zhengguo, Penutmutchu, Srinivasa R., Li, Mei-Ling, Brewer, Gary, Hargrove, Amanda E., Tolbert, Blanton S.

“…Enterovirus 71 (EV71) poses serious threats to human health, particularly in Southeast Asia, and no drugs or vaccines are available. Previous work identified…”
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Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution by Jain, Niyati, Lin, Hsuan-Chun, Morgan, Christopher E., Harris, Michael E., Tolbert, Blanton S.

“…Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multipurpose RNA-binding protein (RBP) involved in normal and pathological RNA metabolism…”
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HnRNP A1/A2 Proteins Assemble onto 7SK snRNA via Context Dependent Interactions by Luo, Le, Chiu, Liang-Yuan, Sugarman, Andrew, Gupta, Paromita, Rouskin, Silvi, Tolbert, Blanton S.

“…[Display omitted] •7SK snRNA adopts two alternate conformers with differences localized to the SL2-3 region.•HnRNP A1 binds selectively to the SL3 domain of…”
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Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function by Levengood, Jeffrey D., Tolbert, Blanton S.

“…The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA binding proteins that function in most stages of RNA metabolism. The…”
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Thermodynamic stability of hnRNP A1 low complexity domain revealed by high‐pressure NMR by Levengood, Jeffrey D., Peterson, Jake, Tolbert, Blanton S., Roche, Julien

“…We have investigated the pressure‐ and temperature‐induced conformational changes associated with the low complexity domain of hnRNP A1, an RNA‐binding protein…”
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EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation by Li, Mei-Ling, Lin, Jing-Yi, Chen, Bo-Shiun, Weng, Kuo-Feng, Shih, Shin-Ru, Calderon, Jesse Davila, Tolbert, Blanton S, Brewer, Gary

“…Enterovirus 71 (EV71) induces apoptosis to promote viral particle release. Earlier work showed that EV71 utilizes its 3C protease to induce apoptosis in a…”
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Integrated approaches to reveal mechanisms by which RNA viruses reprogram the cellular environment by Haddad, Christina, Davila-Calderon, Jesse, Tolbert, Blanton S.

“…RNA viruses are major threats to global society and mass outbreaks can cause long-lasting damage to international economies. RNA and related retro viruses…”
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A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung Cells by Basu, Abhijit, Penumutchu, Srinivasa, Nguyen, Kien, Mbonye, Uri, Tolbert, Blanton S, Karn, Jonathan, Komar, Anton A, Mazumder, Barsanjit

“…The positive-sense, single-stranded RNA genome SARS-CoV-2 harbors functionally important -acting elements governing critical aspects of viral gene expression…”
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Encoded Conformational Dynamics of the HIV Splice Site A3 Regulatory Locus: Implications for Differential Binding of hnRNP Splicing Auxiliary Factors by Chiu, Liang-Yuan, Emery, Ann, Jain, Niyati, Sugarman, Andrew, Kendrick, Nashea, Luo, Le, Ford, William, Swanstrom, Ronald, Tolbert, Blanton S.

“…[Display omitted] •The HIV splice site A3 regulatory locus intrinsically adopts multiple structures in solution, which are phylogenetically conserved across…”
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HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation by Tolbert, Michele, Morgan, Christopher E., Pollum, Marvin, Crespo-Hernández, Carlos E., Li, Mei-Ling, Brewer, Gary, Tolbert, Blanton S.

“…Enteroviruses use a type I Internal Ribosome Entry Site (IRES) structure to facilitate protein synthesis and promote genome replication. Type I IRES elements…”
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Rise in Murine Typhus in Galveston County, Texas, USA, 2018 by Ruiz, Karla, Valcin, Randy, Keiser, Philip, Blanton, Lucas S

“…Murine typhus, an undifferentiated febrile illness caused by Rickettsia typhi, is increasing in prevalence and distribution throughout Texas. In 2018, a total…”
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Editorial for “Methods to characterize virus small RNAs and RNA structures” by Brewer, Gary, Li, Mei-Ling, Tolbert, Blanton S.

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Murine Typhus: A Review of a Reemerging Flea-Borne Rickettsiosis with Potential for Neurologic Manifestations and Sequalae by Blanton, Lucas S.

“…Murine typhus is an acute febrile illness caused by Rickettsia typhi, an obligately intracellular Gram-negative coccobacillus. Rats (Rattus species) and their…”
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Genome-Wide Analysis of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) Binding to HIV-1 RNA Reveals a Key Role for hnRNP H1 in Alternative Viral mRNA Splicing by Kutluay, Sebla B, Emery, Ann, Penumutchu, Srinivasa R, Townsend, Dana, Tenneti, Kasyap, Madison, Michaela K, Stukenbroeker, Amanda M, Powell, Chelsea, Jannain, David, Tolbert, Blanton S, Swanstrom, Ronald I, Bieniasz, Paul D

“…Alternative splicing of HIV-1 mRNAs increases viral coding potential and controls the levels and timing of gene expression. HIV-1 splicing is regulated in part…”
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Enterovirus A71 Vaccines by Li, Mei-Ling, Shih, Shin-Ru, Tolbert, Blanton S, Brewer, Gary

“…Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological…”
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The 5'UTR of HCoV-OC43 adopts a topologically constrained structure to intrinsically repress translation by Mackeown, Matthew, Kung, Yu-An, Davila-Calderon, Jesse, Ford, William P, Luo, Le, Henry, Barrington, Li, Mei-Ling, Brewer, Gary, Shih, Shin-Ru, Tolbert, Blanton S

“…The emergence of SARS-CoV-2, which is responsible for the COVID-19 pandemic, has highlighted the need for rapid characterization of viral mechanisms associated…”
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The Discovery of Antivirals and Targets for SARS‐CoV‐2 and EV‐A71 by Haddad, Christina, Tolbert, Blanton S., Hargrove, Amanda E., Brewer, Gary, Li, Mei‐Ling

“…Positive Strand RNA (PSR) viruses, such as coronaviruses and enteroviruses, cause serious health and economic threats worldwide, as currently seen with the…”
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Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex by Bhat, Prasanna, Aksenova, Vasilisa, Gazzara, Matthew, Rex, Emily A., Aslam, Sadaf, Haddad, Christina, Gao, Shengyan, Esparza, Matthew, Cagatay, Tolga, Batten, Kimberly, El Zahed, Sara S., Arnaoutov, Alexei, Zhong, Hualin, Shay, Jerry W., Tolbert, Blanton S., Dasso, Mary, Lynch, Kristen W., García-Sastre, Adolfo, Fontoura, Beatriz M. A.

“…Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade…”
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Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43 by Dai, Yifan, Wang, Chunlai, Chiu, Liang-Yuan, Abbasi, Kevin, Tolbert, Blanton S., Sauvé, Geneviève, Yen, Yun, Liu, Chung-Chiun

“…A simple-prepare, single-use and cost-effective, in vitro biosensor for the detection of TAR DNA-binding protein 43 (TDP-43), a biomarker of neuro-degenerative…”
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