Search Results - "Blanque, Roland"

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis by Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

“…Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been…”
Get full text

Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis by Taneja, Amit, Desrivot, Julie, Diderichsen, Paul Matthias, Blanqué, Roland, Allamasey, Lisa, Fagard, Liesbeth, Fieuw, Ann, Van der Aar, Ellen, Namour, Florence

“…Background and Objectives GLPG1690 is an autotaxin inhibitor in development for the treatment of idiopathic pulmonary fibrosis. Several publications suggested…”
Get full text

Targeting of αv -Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer by van der Horst, Geertje, van den Hoogen, Christel, Buijs, Jeroen T, Cheung, Henry, Bloys, Henny, Pelger, Rob C.M, Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, van der Pluijm, Gabri

“…Abstract Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile,…”
Get full text

Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization by Blanqué, Roland, Lepescheux, Liên, Auberval, Marielle, Minet, Dominique, Merciris, Didier, Cottereaux, Céline, Clément-Lacroix, Philippe, Delerive, Philippe, Namour, Florence

“…Muscle wasting is a hallmark of many chronic conditions but also of aging and results in a progressive functional decline leading ultimately to disability…”
Get full text

Discovery of 9‑Cyclopropylethynyl-2-((S)‑1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1‑a]­isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial by Labéguère, Frédéric, Dupont, Sonia, Alvey, Luke, Soulas, Florilène, Newsome, Gregory, Tirera, Amynata, Quenehen, Vanessa, Mai, Thi Thu Trang, Deprez, Pierre, Blanqué, Roland, Oste, Line, Le Tallec, Sandrine, De Vos, Steve, Hagers, Annick, Vandevelde, Ann, Nelles, Luc, Vandervoort, Nele, Conrath, Katja, Christophe, Thierry, van der Aar, Ellen, Wakselman, Emanuelle, Merciris, Didier, Cottereaux, Céline, da Costa, Cécile, Saniere, Laurent, Clement-Lacroix, Philippe, Jenkins, Laura, Milligan, Graeme, Fletcher, Stephen, Brys, Reginald, Gosmini, Romain

“…GPR84 is a medium chain free fatty acid-binding G-protein-coupled receptor associated with inflammatory and fibrotic diseases. As the only reported antagonist…”
Get full text

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic by Pizzonero, Mathieu, Dupont, Sonia, Babel, Marielle, Beaumont, Stéphane, Bienvenu, Natacha, Blanqué, Roland, Cherel, Laëtitia, Christophe, Thierry, Crescenzi, Benedetta, De Lemos, Elsa, Delerive, Philippe, Deprez, Pierre, De Vos, Steve, Djata, Fatoumata, Fletcher, Stephen, Kopiejewski, Sabrina, L’Ebraly, Christelle, Lefrançois, Jean-Michel, Lavazais, Stéphanie, Manioc, Murielle, Nelles, Luc, Oste, Line, Polancec, Denis, Quénéhen, Vanessa, Soulas, Florilène, Triballeau, Nicolas, van der Aar, Ellen M, Vandeghinste, Nick, Wakselman, Emanuelle, Brys, Reginald, Saniere, Laurent

“…FFA2, also called GPR43, is a G-protein coupled receptor for short chain fatty acids which is involved in the mediation of inflammatory responses. A class of…”
Get full text

Identification of a 4‑(Hydroxymethyl)diarylhydantoin as a Selective Androgen Receptor Modulator by Nique, François, Hebbe, Séverine, Triballeau, Nicolas, Peixoto, Christophe, Lefrançois, Jean-Michel, Jary, Hélène, Alvey, Luke, Manioc, Murielle, Housseman, Christopher, Klaassen, Hugo, Van Beeck, Kris, Guédin, Denis, Namour, Florence, Minet, Dominque, Van der Aar, Ellen, Feyen, Jean, Fletcher, Stephen, Blanqué, Roland, Robin-Jagerschmidt, Catherine, Deprez, Pierre

“…Structural modification performed on a 4-methyl-4-(4-hydroxyphenyl)hydantoin series is described which resulted in the development of a new series of…”
Get full text

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis by Brebion, Franck, Gosmini, Romain, Deprez, Pierre, Varin, Marie, Peixoto, Christophe, Alvey, Luke, Jary, Hélène, Bienvenu, Natacha, Triballeau, Nicolas, Blanque, Roland, Cottereaux, Céline, Christophe, Thierry, Vandervoort, Nele, Mollat, Patrick, Touitou, Robert, Leonard, Philip, Ceuninck, Frédéric De, Botez, Iuliana, Monjardet, Alain, van der Aar, Ellen, Amantini, David

“…There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan…”
Get full text

Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases by Mammoliti, Oscar, Martina, Sébastien, Claes, Pieter, Coti, Ghjuvanni, Blanque, Roland, Jagerschmidt, Catherine, Shoji, Kenji, Borgonovi, Monica, De Vos, Steve, Marsais, Florence, Oste, Line, Quinton, Evelyne, López-Ramos, Miriam, Amantini, David, Brys, Reginald, Jimenez, Juan-Miguel, Galien, René, van der Plas, Steven

“…Tyrosine kinase 2 (TYK2) mediates cytokine signaling through type 1 interferon, interleukin (IL)-12/IL-23, and the IL-10 family. There appears to be an…”
Get full text

Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer by van der Horst, Geertje, van den Hoogen, Christel, Buijs, Jeroen T, Cheung, Henry, Bloys, Henny, Pelger, Rob C M, Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, van der Pluijm, Gabri

“…Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile, mesenchymal…”
Get full text

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss by Aoki, Kazuhiro, Saito, Hiroaki, Itzstein, Cecile, Ishiguro, Masaji, Shibata, Tatsuya, Blanque, Roland, Mian, Anower Hussain, Takahashi, Mariko, Suzuki, Yoshifumi, Yoshimatsu, Masako, Yamaguchi, Akira, Deprez, Pierre, Mollat, Patrick, Murali, Ramachandran, Ohya, Keiichi, Horne, William C, Baron, Roland

“…Activating receptor activator of NF-kappaB (RANK) and TNF receptor (TNFR) promote osteoclast differentiation. A critical ligand contact site on the TNFR is…”
Get full text

Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer12 by van der Horst, Geertje, van den Hoogen, Christel, Buijs, Jeroen T, Cheung, Henry, Bloys, Henny, Pelger, Rob CM, Lorenzon, Giocondo, Heckmann, Bertrand, Feyen, Jean, Pujuguet, Philippe, Blanque, Roland, Clément-Lacroix, Philippe, van der Pluijm, Gabri

“…Acquisition of an invasive phenotype by cancer cells is a requirement for bone metastasis. Transformed epithelial cells can switch to a motile, mesenchymal…”
Get full text

Discovery of 2‑[[2-Ethyl-6-[4-[2-(3-hydroxy­azetidin-1-yl)-2-oxoethyl]­piperazin-1-yl]-8-methyl­imidazo[1,2‑a]pyridin-3-yl]­methylamino]-4-(4-fluorophenyl)­thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis by Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

“…Autotaxin is a circulating enzyme with a major role in the production of lysophosphatic acid (LPA) species in blood. A role for the autotaxin/LPA axis has been…”
Get full text

FACTORS INFLUENCING THE EFFECT OF THE SOLUBLE IL-6 RECEPTOR ON IL-6 RESPONSES IN HepG2 HEPATOCYTES by Paysant, Jerome, Blanqué, Roland, Vasse, Marc, Soria, Claudine, Soria, Jeannette, Gardner, Colin R

“…The soluble IL-6 receptor (sIL-6R) can increase IL-6-induced signalling by forming a complex with IL-6 and membrane-bound gp130 (the receptor beta chain which…”
Get full text