Search Results - "Blanksby, Stephen J"

Switching radical stability by pH-induced orbital conversion by Gryn'ova, Ganna, Marshall, David L., Blanksby, Stephen J., Coote, Michelle L.

“…In most radicals the singly occupied molecular orbital (SOMO) is the highest-energy occupied molecular orbital (HOMO); however, in a small number of reported…”
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Advances in mass spectrometry for lipidomics by Blanksby, Stephen J, Mitchell, Todd W

“…Recent expansion in research in the field of lipidomics has been driven by the development of new mass spectrometric tools and protocols for the identification…”
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Bond Dissociation Energies of Organic Molecules by Blanksby, Stephen J, Ellison, G. Barney

“…In this Account we have compiled a list of reliable bond energies that are based on a set of critically evaluated experiments. A brief description of the three…”
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Differentiation of Complex Lipid Isomers by Radical-Directed Dissociation Mass Spectrometry by Pham, Huong T, Ly, Tony, Trevitt, Adam J, Mitchell, Todd W, Blanksby, Stephen J

“…Contemporary lipidomics protocols are dependent on conventional tandem mass spectrometry for lipid identification. This approach is extremely powerful for…”
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High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales by Poad, Berwyck L. J, Green, Martin R, Kirk, Jayne M, Tomczyk, Nick, Mitchell, Todd W, Blanksby, Stephen J

“…Ozone-induced dissociation (OzID) is a novel ion activation technology that exploits the gas-phase reaction between mass-selected ions and ozone inside a mass…”
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Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging by Hamilton, Brett R., Marshall, David L., Casewell, Nicholas R., Harrison, Robert A., Blanksby, Stephen J., Undheim, Eivind A. B.

“…Enzymes are central components of most physiological processes, and are consequently implicated in various pathologies. High‐resolution maps of enzyme activity…”
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Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome by Menzel, Jan Philipp, Young, Reuben S. E., Benfield, Aurélie H., Scott, Julia S., Wongsomboon, Puttandon, Cudlman, Lukáš, Cvačka, Josef, Butler, Lisa M., Henriques, Sónia T., Poad, Berwyck L. J., Blanksby, Stephen J.

“…Fatty acid isomers are responsible for an under-reported lipidome diversity across all kingdoms of life. Isomers of unsaturated fatty acids are often masked in…”
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Solvent-Mediated Proton-Transfer Catalysis of the Gas-Phase Isomerization of Ciprofloxacin Protomers by Ucur, Boris, Maccarone, Alan T, Ellis, Shane R, Blanksby, Stephen J, Trevitt, Adam J

“…Understanding how neutral molecules become protonated during positive-ion electrospray ionization (ESI) mass spectrometry is critically important to ensure…”
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Apocryphal FADS2 activity promotes fatty acid diversification in cancer by Young, Reuben S.E., Bowman, Andrew P., Williams, Elizabeth D., Tousignant, Kaylyn D., Bidgood, Charles L., Narreddula, Venkateswara R., Gupta, Rajesh, Marshall, David L., Poad, Berwyck L.J., Nelson, Colleen C., Ellis, Shane R., Heeren, Ron M.A., Sadowski, Martin C., Blanksby, Stephen J.

“…Canonical fatty acid metabolism describes specific enzyme-substrate interactions that result in products with well-defined chain lengths, degree(s), and…”
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Discrimination between Protonation Isomers of Quinazoline by Ion Mobility and UV-Photodissociation Action Spectroscopy by Marlton, Samuel J. P, McKinnon, Benjamin I, Ucur, Boris, Bezzina, James P, Blanksby, Stephen J, Trevitt, Adam J

“…The influence of oriented electric fields on chemical reactivity and photochemistry is an area of increasing interest. Within a molecule, different protonation…”
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Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry[S] by Maccarone, Alan T., Duldig, Jackson, Mitchell, Todd W., Blanksby, Stephen J., Duchoslav, Eva, Campbell, J. Larry

“…Glycerophospholipids (GPs) that differ in the relative position of the two fatty acyl chains on the glycerol backbone (i.e., sn-positional isomers) can have…”
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Structural characterization of glycerophospholipids by combinations of ozone- and collision-induced dissociation mass spectrometry: the next step towards "top-down" lipidomics by Pham, Huong T, Maccarone, Alan T, Thomas, Michael C, Campbell, J Larry, Mitchell, Todd W, Blanksby, Stephen J

“…The complete structural elucidation of complex lipids, including glycerophospholipids, using only mass spectrometry represents a major challenge to…”
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Analysis of unsaturated lipids by ozone-induced dissociation by Brown, Simon H.J., Mitchell, Todd W., Blanksby, Stephen J.

“…Recent developments in analytical technologies have driven significant advances in lipid science. The sensitivity and selectivity of modern mass spectrometers…”
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Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance by Benfield, Aurélie H., Vernen, Felicitas, Young, Reuben S.E., Nadal-Bufí, Ferran, Lamb, Henry, Hammerlindl, Heinz, Craik, David J., Schaider, Helmut, Lawrence, Nicole, Blanksby, Stephen J., Henriques, Sónia Troeira

“…Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that…”
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A comparison of patient matched meibum and tear lipidomes by Brown, Simon H J, Kunnen, Carolina M E, Duchoslav, Eva, Dolla, Naveen K, Kelso, Michael J, Papas, Eric B, Lazon de la Jara, Percy, Willcox, Mark D P, Blanksby, Stephen J, Mitchell, Todd W

“…To quantify the molecular lipid composition of patient-matched tear and meibum samples and compare tear and meibum lipid molecular profiles. Lipids were…”
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Ozone-Induced Dissociation:  Elucidation of Double Bond Position within Mass-Selected Lipid Ions by Thomas, Michael C, Mitchell, Todd W, Harman, David G, Deeley, Jane M, Nealon, Jessica R, Blanksby, Stephen J

“…Ions formed from lipids during electrospray ionization of crude lipid extracts have been mass-selected within a quadrupole linear ion trap mass spectrometer…”
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Sequential Collision- and Ozone-Induced Dissociation Enables Assignment of Relative Acyl Chain Position in Triacylglycerols by Marshall, David L, Pham, Huong T, Bhujel, Mahendra, Chin, Jacqueline S. R, Yew, Joanne Y, Mori, Kenji, Mitchell, Todd W, Blanksby, Stephen J

“…Unambiguous identification of isomeric lipids by mass spectrometry represents a significant analytical challenge in contemporary lipidomics. Herein, the…”
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Mass spectrometry as a tool to advance polymer science by De Bruycker, Kevin, Welle, Alexander, Hirth, Sabine, Blanksby, Stephen J., Barner-Kowollik, Christopher

“…In contrast to natural polymers, which have existed for billions of years, the first well-understood synthetic polymers date back to just over one century ago…”
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Isomeric lipid signatures reveal compartmentalized fatty acid metabolism in cancer by Young, Reuben S.E., Bowman, Andrew P., Tousignant, Kaylyn D., Poad, Berwyck L.J., Gunter, Jennifer H., Philp, Lisa K., Nelson, Colleen C., Ellis, Shane R., Heeren, Ron M.A., Sadowski, Martin C., Blanksby, Stephen J.

“…The cellular energy and biomass demands of cancer drive a complex dynamic between uptake of extracellular FAs and their de novo synthesis. Given that oxidation…”
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Surface analysis of lipids by mass spectrometry: More than just imaging by Ellis, Shane R., Brown, Simon H., in het Panhuis, Marc, Blanksby, Stephen J., Mitchell, Todd W.

“…Mass spectrometry is now an indispensable tool for lipid analysis and is arguably the driving force in the renaissance of lipid research. In its various forms,…”
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