Search Results - "Blaney Davidson, Esmeralda N."

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice by Blaney Davidson, Esmeralda N, Remst, Dennis F. G, Vitters, Elly L, van Beuningen, Henk M, Blom, Arjen B, Goumans, Marie-Jose, van den Berg, Wim B, van der Kraan, Peter M

“…During osteoarthritis (OA) chondrocytes show deviant behavior resembling terminal differentiation of growth-plate chondrocytes, characterized by elevated…”
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The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis by Blom, Arjen B, van den Bosch, Martijn H, Blaney Davidson, Esmeralda N, Roth, Johannes, Vogl, Thomas, van de Loo, Fons A, Koenders, Marije, van der Kraan, Peter M, Geven, Edwin J, van Lent, Peter L

“…Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor…”
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Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by de Kroon, Laurie M G, Narcisi, Roberto, Blaney Davidson, Esmeralda N, Cleary, Mairéad A, van Beuningen, Henk M, Koevoet, Wendy J L M, van Osch, Gerjo J V M, van der Kraan, Peter M

“…Bone marrow-derived mesenchymal stem cells (BMSCs) are promising for cartilage regeneration because BMSCs can differentiate into cartilage tissue-producing…”
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A roadmap to target interleukin-6 in osteoarthritis by Wiegertjes, Renske, van de Loo, Fons A J, Blaney Davidson, Esmeralda N

“…Abstract Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease…”
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Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells by Heldens, Genoveva T H, Blaney Davidson, Esmeralda N, Vitters, Elly L, Schreurs, B Willem, Piek, Ester, van den Berg, Wim B, van der Kraan, Peter M

“…Articular cartilage has a very limited intrinsic repair capacity leading to progressive joint damage. Therapies involving tissue engineering depend on…”
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Early pain in females is linked to late pathological features in murine experimental osteoarthritis by Valdrighi, Natália, Blom, Arjen B, van Beuningen, Henk M, Vitters, Elly L, Helsen, Monique M, Walgreen, Birgitte, van Lent, Peter L E M, Koenders, Marije I, van der Kraan, Peter M, van de Loo, Fons A J, Blaney Davidson, Esmeralda N

“…Osteoarthritis (OA) is a progressive joint disease and a major cause of chronic pain in adults. The prevalence of OA is higher in female patients, who tend to…”
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Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness by Remst, Dennis F G, Blaney Davidson, Esmeralda N, van der Kraan, Peter M

“…Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the main symptoms of OA. At this moment the underlying…”
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Sclerostin antibody enhances implant osseointegration in bone with Col1a1 mutation by Sung, Hsiao H., Kwon, Hanna H., Stephan, Chris, Reynolds, Skylar M., Dai, Zongrui, Van der Kraan, Peter M., Caird, Michelle S., Blaney Davidson, Esmeralda N., Kozloff, Kenneth M.

“…We evaluated the potential of sclerostin antibody (SclAb) therapy to enhance osseointegration of dental and orthopaedic implants in a mouse model (Brtl/+)…”
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Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation by Broeren, Mathijs G A, Di Ceglie, Irene, Bennink, Miranda B, van Lent, Peter L E M, van den Berg, Wim B, Koenders, Marije I, Blaney Davidson, Esmeralda N, van der Kraan, Peter M, van de Loo, Fons A J

“…Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage…”
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Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes by Thielen, Nathalie G.M., van Caam, Arjan P.M., v. Beuningen, Henk M., Vitters, Elly L., van den Bosch, Martijn H.J., Koenders, Marije I., van de Loo, Fons A.J., Blaney Davidson, Esmeralda N., van der Kraan, Peter M.

“…Transforming growth factor-β (TGF-β) signaling via SMAD2/3 is crucial to control cartilage homeostasis. However, TGF-β can also have detrimental effects by…”
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Sex Differences in Pain Sensitivity in a Dutch Cohort: Cross-Sectional and Web-Based Multidimensional Study by Smits, Rachel J H, van der Wal, Selina E I, van Boekel, Regina L M, Timmerman, Hans, Bronkhorst, Ewald M, Abrar, Diana, Vissers, Kris C P, Blaney Davidson, Esmeralda N, Steegers, Monique A H

“…Sex is an important factor influencing the development and treatment of chronic pain, but the extent of its influence is still unclear. Other demographic…”
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SMAD3 and SMAD4 have a more dominant role than SMAD2 in TGFβ-induced chondrogenic differentiation of bone marrow-derived mesenchymal stem cells by de Kroon, Laurie M. G., Narcisi, Roberto, van den Akker, Guus G. H., Vitters, Elly L., Blaney Davidson, Esmeralda N., van Osch, Gerjo J. V. M., van der Kraan, Peter M.

“…To improve cartilage formation by bone marrow-derived mesenchymal stem cells (BMSCs), the signaling mechanism governing chondrogenic differentiation requires…”
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A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis by DER KRAAN, Peter M.van, BLANEY DAVIDSON, Esmeralda N, VAN DEN BERG, Wim B

“…Transforming growth factor beta (TGFβ) is a growth factor with many faces. In our osteoarthritis (OA) research we have found that TGFβ can be protective as…”
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Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain? by Valdrighi, Natália, Vago, Juliana P, Blom, Arjen B, van de Loo, Fons A J, Blaney Davidson, Esmeralda N

“…Osteoarthritis (OA) is a progressive whole-joint disease; no disease-modifying drugs are currently available to stop or slow its process. Symptoms alleviation…”
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Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation by Oliveira, Marina C., Arntz, Onno J., Blaney Davidson, Esmeralda N., van Lent, Peter L.E.M., Koenders, Marije I., van der Kraan, Peter M., van den Berg, Wim B., Ferreira, Adaliene V.M., van de Loo, Fons A.J.

“…The claimed beneficial effect of milk on bone is still a matter for debate. Recently extracellular vesicles (EVs) that contain proteins and RNA were discovered…”
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Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8 by van den Bosch, Martijn H., Blom, Arjen B., van Lent, Peter L., van Beuningen, Henk M., Blaney Davidson, Esmeralda N., van der Kraan, Peter M., van den Berg, Wim B.

“…Both Wnt signaling and TGF-β signaling have been implicated in the regulation of the phenotype of many cell types including chondrocytes, the only cell type…”
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Interleukin 1 β-induced SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in primary human mesenchymal stem cells by van den Akker, Guus G., van Beuningen, Henk M., Vitters, Elly L., Koenders, Marije I., van de Loo, Fons A., van Lent, Peter L., Blaney Davidson, Esmeralda N., van der Kraan, Peter M.

“…Chondrogenic differentiation of mesenchymal stem cells (MSC) requires transforming growth factor beta (TGFβ) signaling. TGFβ binds to the type I receptor…”
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Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification by Hellingman, Catharine A, Davidson, Esmeralda N Blaney, Koevoet, Wendy, Vitters, Elly L, van den Berg, Wim B, van Osch, Gerjo J V M, van der Kraan, Peter M

“…The aim of this study was to investigate the roles of Smad2/3 and Smad1/5/8 phosphorylation in transforming growth factor-beta-induced chondrogenic…”
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Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets by de Kroon, Laurie M.G., van den Akker, Guus G.H., Brachvogel, Bent, Narcisi, Roberto, Belluoccio, Daniele, Jenner, Florien, Bateman, John F., Little, Christopher B., Brama, Pieter A.J., Blaney Davidson, Esmeralda N., van der Kraan, Peter M., van Osch, Gerjo J.V.M.

“…Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy…”
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Cross-talk between bone morphogenetic proteins and inflammatory pathways by van der Kraan, Peter M, Davidson, Esmeralda N Blaney

“…Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and…”
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