Search Results - "Blander, J M"

Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells by Amsen, Derk, Blander, J.Magarian, Lee, Gap Ryol, Tanigaki, Kenji, Honjo, Tasuku, Flavell, Richard A

“…Antigen-presenting cells (APC) tailor immune responses to microbial encounters by stimulating differentiation of CD4 T cells into the Th1 and Th2 lineages. We…”
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Alpha(1,3)-fucosyltransferase VII and alpha(2,3)-sialyltransferase IV are up-regulated in activated CD4 T cells and maintained after their differentiation into Th1 and migration into inflammatory sites by Blander, J M, Visintin, I, Janeway, Jr, C A, Medzhitov, R

“…Activated Th1 CD4 T cells bind to P-selectin and migrate into inflamed tissue, whereas Th2 cells do not. We show that alpha(1, 3)-fucosyltransferase VII…”
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Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2 by Blander, J M, Sant'Angelo, D B, Bottomly, K, Janeway, Jr, C A

“…To study whether changes in the structure of a T cell receptor (TCR) at a single peptide-contacting residue could affect T cell priming with antigenic peptide,…”
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Simultaneous targeting of toll- and nod-like receptors induces effective tumor-specific immune responses by Garaude, Johan, Kent, Andrew, van Rooijen, Nico, Blander, J Magarian

“…Toll-like receptor (TLR) ligands are increasingly being used as adjuvants in cancer vaccine trials to harness innate immunity and prime effective antitumor…”
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A Pool of Central Memory-Like CD4 T Cells Contains Effector Memory Precursors by Blander, J. Magarian, Sant'Angelo, Derek B, Metz, Daniela, Kim, Sang-Won, Flavell, Richard A, Bottomly, Kim, Janeway, Charles A., Jr

“…The L51S mutation in the D10.G4.1 TCR alpha-chain reduces the affinity of the TCR to its ligand by affecting the interactions among the TCR, the beta-chain of…”
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Recognition of a Specific Self-Peptide: Self-MHC Class II Complex Is Critical for Positive Selection of Thymocytes Expressing the D10 TCR by Dao, Tao, Blander, J. Magarian, Sant'Angelo, Derek B

“…We examined the specificity of positive and negative selection by using transgenic mice carrying a variant of the D10 TCR. We demonstrate that a point mutation…”
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Coupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation by Blander, J. Magarian

“…Much attention has focused on the role of co-stimulation in dictating tolerance versus immunity to internalized antigens, with the assumption that the…”
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Apoptotic cell death in disease—Current understanding of the NCCD 2023 by Pietrocola, Federico, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Alnemri, Emad S., Altucci, Lucia, Arama, Eli, Becker, Christoph, Bianchi, Marco E., Blomgren, Klas, Borner, Christoph, Calin, George A., Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Chen, Guo-Qiang, Chen, Youhai H., Ciliberto, Gennaro, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., De Strooper, Bart, Deberardinis, Ralph J., Degterev, Alexei, Deshmukh, Mohanish, Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Ghosh, Sourav, Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hengartner, Michael O., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Kaufmann, Thomas, Kelly, Gemma L., Krysko, Dmitri V., Kumar, Sharad, Lavrik, Inna N., López-Otín, Carlos, Luedde, Tom, Madeo, Frank, Malorni, Walter, Mantovani, Roberto, Martinou, Jean-Claude, Mehlen, Patrick, Melino, Gerry, Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Opferman, Joseph T., Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Pentimalli, Francesca, Pervaiz, Shazib, Porta, Giovanni, Prehn, Jochen H. M., Rabinovich, Gabriel A., Rehm, Markus, Rizzuto, Rosario, Rudel, Thomas, Ryan, Kevin M., Sayan, Emre, Shao, Feng, Sica, Giuseppe S., Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Tait, Stephen W. G., Tavernarakis, Nektarios, Turk, Boris, Vandenabeele, Peter, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wallach, David, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Piacentini, Mauro, Galluzzi, Lorenzo

“…Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally…”
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Toll-dependent selection of microbial antigens for presentation by dendritic cells by Blander, J. Magarian, Medzhitov, Ruslan

“…Dendritic cells constitutively sample the tissue microenvironment and phagocytose both microbial and host apoptotic cells. This leads to the induction of…”
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Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors by Blander, J Magarian

“…Professional phagocytes play an important role in the clearance of microbial pathogens and apoptotic cells. Many receptors are involved in this process, some…”
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Regulation of Phagosome Maturation by Signals from Toll-like Receptors by Blander, J. Magarian, Medzhitov, Ruslan

“…In higher metazoans, phagocytosis is essential in host defense against microbial pathogens and in clearance of apoptotic cells. Both microbial and apoptotic…”
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Screening of anti-MUC1 antibodies for reactivity with native (ascites) and recombinant (baculovirus) MUC1 and for blocking MUC1 specific cytotoxic T-lymphocytes by Ciborowski, P, Konitzki, W M, Blander, J M, Finn, O J

“…We report the results of a panel of 56 monoclonal antibodies submitted to the ISOBM TD-4 Workshop for the study of the epithelial MUC1 mucin. We used three…”
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Innate Immune Cells Cast an Eye on DNA by Sander, Leif E., Blander, J. Magarian

“…The threonine phosphatase eyes absent (EYA) has been identified as a novel regulator of innate immune responses to cytosolic nucleic acids and undigested DNA…”
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