Search Results - "Blanden, Adam R"

The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect by Woodford, Mark R., Baker-Williams, Alexander J., Sager, Rebecca A., Backe, Sarah J., Blanden, Adam R., Hashmi, Fiza, Kancherla, Priyanka, Gori, Alessandro, Loiselle, David R., Castelli, Matteo, Serapian, Stefano A., Colombo, Giorgio, Haystead, Timothy A., Jensen, Sandra M., Stetler-Stevenson, William G., Loh, Stewart N., Schmidt, Laura S., Linehan, W. Marston, Bah, Alaji, Bourboulia, Dimitra, Bratslavsky, Gennady, Mollapour, Mehdi

“…Aerobic glycolysis in cancer cells, also known as the ‘Warburg effect’, is driven by hyperactivity of lactate dehydrogenase A (LDHA). LDHA is thought to be a…”
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Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants by Blanden, Adam R, Yu, Xin, Blayney, Alan J, Demas, Christopher, Ha, Jeung-Hoi, Liu, Yue, Withers, Tracy, Carpizo, Darren R, Loh, Stewart N

“…Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies…”
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding by Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi

“…Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling…”
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Rare Sighting of Posterior Communicating Artery Infundibulum With Posterior Cerebral Artery Origin by Suryadevara, Naveen K, Draytsel, Dan Y, Suryadevara, Neil C, Blanden, Adam R, Masoud, Hesham

“…Infundibula are funnel-shaped lesions that develop at the intersections of major intracranial arteries. These lesions are prone to being misdiagnosed as…”
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Abstract 117: Digitally Subtracted Angiogram & Biopsy Negative Recurrent Spontaneous Bilateral Anterior Cerebral Artery Territory Intracranial Hemorrhage by Blanden, Adam R., Johnson, Griffin, Reddy, Aravind, Burke, Devin, Swarnkar, Amar, Masoud, Hesham

“…IntroductionUp to 18% of spontaneous intracerebral hemorrhages are cryptogenic despite a thorough workup, usually noted in a lobar location. Although…”
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Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer by Blanden, Adam R., Yu, Xin, Loh, Stewart N., Levine, Arnold J., Carpizo, Darren R.

“…•Reactivating mutant p53 through zinc metallochaperones.•Zinc metallochaperones restore zinc to zinc-deficient mutant p53.•Zinc metallochaperones function by…”
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An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models by Celli, Jonathan P., Rizvi, Imran, Blanden, Adam R., Massodi, Iqbal, Glidden, Michael D., Pogue, Brian W., Hasan, Tayyaba

“…While it is increasingly recognized that three-dimensional (3D) cell culture models recapitulate drug responses of human cancers with more fidelity than…”
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Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients by Woodford, Mark R, Sager, Rebecca A, Marris, Elijah, Dunn, Diana M, Blanden, Adam R, Murphy, Ryan L, Rensing, Nicholas, Shapiro, Oleg, Panaretou, Barry, Prodromou, Chrisostomos, Loh, Stewart N, Gutmann, David H, Bourboulia, Dimitra, Bratslavsky, Gennady, Wong, Michael, Mollapour, Mehdi

“…The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise…”
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Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53 by Gilleran, John A, Yu, Xin, Blayney, Alan J, Bencivenga, Anthony F, Na, Bing, Augeri, David J, Blanden, Adam R, Kimball, S. David, Loh, Stewart N, Roberge, Jacques Y, Carpizo, Darren R

“…We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc…”
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Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin by Qi, Jun, Blanden, Adam R., Bane, Susan, Kingston, David G.I.

“…The design, synthesis, and biological evaluation of a simplified fluorescently labeled discodermolide analogue possessing a dimethylaminobenzoyl fluorophore…”
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Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer by Ahanin, Elham F, Sager, Rebecca A, Backe, Sarah J, Dunn, Diana M, Dushukyan, Natela, Blanden, Adam R, Mate, Nilamber A, Suzuki, Tamie, Anderson, Tyler, Roy, Merin, Oberoi, Jasmeen, Prodromou, Chrisostomos, Nsouli, Imad, Daneshvar, Michael, Bratslavsky, Gennady, Woodford, Mark R, Bourboulia, Dimitra, Chisholm, John D, Mollapour, Mehdi

“…Serine/threonine protein phosphatase-5 (PP5) is involved in tumor progression and survival, making it an attractive therapeutic target. Specific inhibition of…”
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Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore by Blanden, Adam R, Yu, Xin, Wolfe, Aaron J, Gilleran, John A, Augeri, David J, O'Dell, Ryan S, Olson, Eric C, Kimball, S David, Emge, Thomas J, Movileanu, Liviu, Carpizo, Darren R, Loh, Stewart N

“…p53 is a Zn(2+)-dependent tumor suppressor inactivated in >50% of human cancers. The most common mutation, R175H, inactivates p53 by reducing its affinity for…”
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Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism by Yu, Xin, Blanden, Adam R, Narayanan, Sumana, Jayakumar, Lalithapriya, Lubin, David, Augeri, David, Kimball, S David, Loh, Stewart N, Carpizo, Darren R

“…NSC319726 (ZMC1) is a small molecule that reactivates mutant p53 by restoration of WT structure/function to the most common p53 missense mutant (p53-R175H). We…”
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Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding by Zaman, Saif, Yu, Xin, Bencivenga, Anthony F, Blanden, Adam R, Liu, Yue, Withers, Tracy, Na, Bing, Blayney, Alan J, Gilleran, John, Boothman, David A, Loh, Stewart N, Kimball, S David, Carpizo, Darren R

“…Chemotherapy and radiation are more effective in wild-type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate…”
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4-Aminophenylalanine as a Biocompatible Nucleophilic Catalyst for Hydrazone Ligations at Low Temperature and Neutral pH by Blanden, Adam R, Mukherjee, Kamalika, Dilek, Ozlem, Loew, Maura, Bane, Susan L

“…Hydrazone formation and similar reactions are highly versatile and specific, but their application to biological systems has been limited by their…”
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Quantification of Membrane Protein-Detergent Complex Interactions by Wolfe, Aaron J, Si, Wei, Zhang, Zhengqi, Blanden, Adam R, Hsueh, Yi-Ching, Gugel, Jack F, Pham, Bach, Chen, Min, Loh, Stewart N, Rozovsky, Sharon, Aksimentiev, Aleksei, Movileanu, Liviu

“…Although fundamentally significant in structural, chemical, and membrane biology, the interfacial protein-detergent complex (PDC) interactions have been…”
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Interrogating Detergent Desolvation of Nanopore-Forming Proteins by Fluorescence Polarization Spectroscopy by Wolfe, Aaron J, Hsueh, Yi-Ching, Blanden, Adam R, Mohammad, Mohammad M, Pham, Bach, Thakur, Avinash K, Loh, Stewart N, Chen, Min, Movileanu, Liviu

“…Understanding how membrane proteins interact with detergents is of fundamental and practical significance in structural and chemical biology as well as in…”
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Abstract Number ‐ 122: Minimally symptomatic left M1 occlusion from carotid web by Eskian, Mahsa, Hoffman, Haydn, Blanden, Adam R, Gould, Grahame C, Masoud, Hesham

“…IntroductionMinimally symptomatic large vessel occlusion (LVO) is an area of prognostic and management uncertainty. Current guidelines recommend thrombectomy…”
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Abstract Number ‐ 89: Left M1 occlusion rescued by the Recurrent artery of Huebner: a spectrum of MCA collaterals by Blanden, Adam R, Raveendran, Laxshika, Titoff, Victoria, Swarnkar, Amar S, Masoud, Hesham

“…Abstract only…”
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Abstract Number ‐ 224: Stroke Mimic—Patient with Symptomatic Amyloid‐Related Imaging Abnormalities Presenting with Stroke‐like Symptoms by Kmeid, Michael, Blanden, Adam R, Kaur, Navreet, Clos, Siara, Masoud, Hesham

“…Abstract only…”
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