Search Results - "Bland, Ross"

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial by Kaplitt, Michael G, MDPhD, Feigin, Andrew, MD, Tang, Chengke, MD, Fitzsimons, Helen L, PhD, Mattis, Paul, PhD, Lawlor, Patricia A, PhD, Bland, Ross J, PhD, Young, Deborah, PhD, Strybing, Kristin, MSc, Eidelberg, David, MD, During, Matthew J, MDDSc

“…Summary Background Dopaminergic neuronal loss in Parkinson's disease leads to changes in the circuitry of the basal ganglia, such as decreased inhibitory…”
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The bacterial community associated with the sheep gastrointestinal nematode parasite Haemonchus contortus by Sinnathamby, Gajenathirin, Henderson, Gemma, Umair, Saleh, Janssen, Peter, Bland, Ross, Simpson, Heather

“…Culture-independent methods were used to study the microbiota of adult worms, third-stage larvae and eggs, both in faeces and laid in vitro, of Haemonchus…”
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Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates by Lawlor, Patricia A, Bland, Ross J, Mouravlev, Alexandre, Young, Deborah, During, Matthew J

“…Adeno-associated viral (AAV) vectors have become the primary delivery agent for somatic gene transfer into the central nervous system (CNS). To date,…”
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Employment After Radiation Oncology Residency: A Survey of the Class of 2014 by Bland, Ross E., MD, Hodges, Joseph C., MD, MBA, Folkert, Michael R., MD, PhD, Iyengar, Puneeth, MD, PhD, Meyer, Jeffrey J., MD, MS

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Metabolic syndrome is a sequela of radiation exposure in hypothalamic obesity among survivors of childhood brain tumors by Cooksey, Raven, Wu, Susan Y, Klesse, Laura, Oden, Jon D, Bland, Ross E, Hodges, Joseph C, Gargan, Lynn, Vega, Gloria Lena, Bowers, Daniel C

“…Survivors of childhood brain tumors may be at risk for early onset of metabolic syndrome, possibly secondary to surgery and/or radiation exposure. This study…”
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Correction: The bacterial community associated with the sheep gastrointestinal nematode parasite Haemonchus contortus by Sinnathamby, Gajenthiran, Henderson, Gemma, Umair, Saleh, Janssen, Peter, Bland, Ross, Simpson, Heather

“…[This corrects the article DOI: 10.1371/journal.pone.0192164.]…”
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Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage by Aleyasin, Hossein, Rousseaux, Maxime W.C, Phillips, Maryam, Kim, Raymond H, Bland, Ross J, Callaghan, Steve, Slack, Ruth S, During, Matthew J, Mak, Tak W, Park, David S

“…Recent evidence has indicated that common mechanisms play roles among multiple neurological diseases. However, the specifics of these pathways are not…”
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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection by During, Matthew J, Cao, Lei, Zuzga, David S, Francis, Jeremy S, Fitzsimons, Helen L, Jiao, Xiangyang, Bland, Ross J, Klugmann, Matthias, Banks, William A, Drucker, Daniel J, Haile, Colin N

“…Glucagon-like peptide-1 (GLP-1) is a gut peptide that, together with its receptor, GLP-1R, is expressed in the brain. Here we show that intracerebroventricular…”
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Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo by Rashidian, Juliet, Rousseaux, Maxime W, Venderova, Katerina, Qu, Dianbo, Callaghan, Steve M, Phillips, Maryam, Bland, Ross J, During, Matthew J, Mao, Zixu, Slack, Ruth S, Park, David S

“…Recent evidence suggests that abnormal activation of cyclin-dependent kinase 5 (cdk5) is a critical prodeath signal in stroke. However, the mechanism(s) by…”
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Adaptive Radiation Therapy for Intact Thymoma: An Illustrative Report by Chevli, Neil, Bland, Ross E, Farach, Andrew M, Pino, Ramiro, Mathews, Thomas, Okoye, Ekene I, Blackmon, Shanda, Butler, E Brian, Teh, Bin S

“…Adaptive radiation therapy (ART) is a technique capable of reducing radiation dose to normal tissue without compromising local control. For potentially…”
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Oncoprotein Akt/PKB Induces Trophic Effects in Murine Models of Parkinson's Disease by Ries, Vincent, Henchcliffe, Claire, Kareva, Tatyana, Rzhetskaya, Margarita, Bland, Ross, During, Matthew J., Kholodilov, Nikolai, Burke, Robert E.

“…Despite promising preclinical studies, neurotrophic factors have not yet achieved an established role in the treatment of human neurodegenerative diseases. One…”
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Role of Noradrenergic Signaling by the Nucleus Tractus Solitarius in Mediating Opiate Reward by Olson, Valerie G, Heusner, Carrie L, Bland, Ross J, During, Matthew J, Weinshenker, David, Palmiter, Richard D

“…Norepinephrine (NE) is widely implicated in opiate withdrawal, but much less is known about its role in opiate-induced locomotion and reward. In mice lacking…”
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Multiple Cyclin-Dependent Kinases Signals Are Critical Mediators of Ischemia/Hypoxic Neuronal Death in vitro and in vivo by Rashidian, Juliet, Iyirhiaro, Grace, Aleyasin, Hossein, Rios, Mario, Vincent, Inez, Callaghan, Steven, Bland, Ross J., Slack, Ruth S., During, Matthew J., Park, David S., Mak, Tak Wah

“…The mechanisms involving neuronal death after ischemic/hypoxic insult are complex, involving both rapid (excitotoxic) and delayed (apoptotic-like) processes…”
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Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels by Lawlor, Patricia A, Bland, Ross J, Das, Pritam, Price, Robert W, Holloway, Vallie, Smithson, Lisa, Dicker, Bridget L, During, Matthew J, Young, Deborah, Golde, Todd E

“…BACKGROUND: Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques…”
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Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B by Ries, Vincent, Cheng, Hsiao-Chun, Baohan, Amy, Kareva, Tatyana, Oo, Tinmarla F, Rzhetskaya, Margarita, Bland, Ross J, During, Matthew J, Kholodilov, Nikolai, Burke, Robert E

“…Following mitosis, specification and migration during embryogenesis, dopamine neurons of the mesencephalon undergo a postnatal naturally occurring cell death…”
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HSP70 and Constitutively Active HSF1 Mediate Protection Against CDCrel-1-mediated Toxicity by Jung, Alisha E, Fitzsimons, Helen L, Bland, Ross J, During, Matthew J, Young, Deborah

“…Defects in cellular quality control mechanisms are thought to contribute to the neuropathology of Parkinson's disease (PD). Overexpressing heat shock proteins…”
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Nucleotide allosteric regulation of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus by Umair, Saleh, Knight, Jacqueline S., Patchett, Mark L., Bland, Ross J., Simpson, Heather V.

“…The expression of glutamate dehydrogenase (GDH; EC 1.4.1.3) in L3 of the nematode Haemonchus contortus was confirmed by detecting GDH mRNA, contrary to earlier…”
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Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat by Fitzsimons, Helen L., Riban, Veronique, Bland, Ross J., Wendelken, Jennifer L., Sapan, Christine V., During, Matthew J.

“…Background The steps necessary to translate promising new biological therapies to the clinic are poorly documented. For gene therapy, there are unique aspects…”
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Dosimetric and motion analysis of margin-intensive therapy by stereotactic ablative radiotherapy for resectable pancreatic cancer by Heinzerling, John H, Bland, Ross, Mansour, John C, Schwarz, Roderich E, Ramirez, Ezequiel, Ding, Chuxiong, Abdulrahman, Ramzi, Boike, Thomas P, Solberg, Timothy, Timmerman, Robert D, Meyer, Jeffrey J

“…The retroperitoneal margin is a common site of positive surgical margins in patients with resectable pancreatic cancer. Preoperative margin-intensive therapy…”
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Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain by Fitzsimons, Helen L, Bland, Ross J, During, Matthew J

“…Since the first demonstration of central nervous system (CNS) transduction with recombinant adeno-associated virus, improvements in vector production and…”
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