Search Results - "Bland, Richard"
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Life-saving effect of pulmonary surfactant in premature babies
Published in The Journal of clinical investigation (01-05-2024)“…The discovery and replacement of lung surfactant have helped increase survival rates for neonatal respiratory distress syndrome in extremely premature infants…”
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Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling
Published in American journal of respiratory and critical care medicine (01-06-2015)“…Pulmonary arterial hypertension is characterized by endothelial dysfunction, impaired bone morphogenetic protein receptor 2 (BMPR2) signaling, and increased…”
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Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency
Published in Chest (01-10-2021)“…Preclinical evidence implicates neutrophil elastase (NE) in pulmonary arterial hypertension (PAH) pathogenesis, and the NE inhibitor elafin is under early…”
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Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice
Published in American journal of physiology. Lung cellular and molecular physiology (01-01-2010)“…Defective lung septation and angiogenesis, quintessential features of neonatal chronic lung disease (CLD), typically result from lengthy exposure of developing…”
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Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice
Published in American journal of respiratory cell and molecular biology (01-11-2018)“…Mechanical ventilation with O -rich gas (MV-O ) inhibits alveologenesis and lung growth. We previously showed that MV-O increased elastase activity and…”
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Social Protest in Russian America
Published in Sibirica : the journal of Siberian studies (01-12-2021)“…This article analyzes social protest in the Russian colonies in Alaska and Northern California. The main reasons for protests were the actions of the colonial…”
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Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth
Published in American journal of physiology. Lung cellular and molecular physiology (01-08-2012)“…Mechanical ventilation (MV) with O(2)-rich gas (MV-O(2)) offers life-saving treatment for newborn infants with respiratory failure, but it also can promote…”
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Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice
Published in American journal of respiratory and critical care medicine (01-09-2011)“…Mechanical ventilation with O₂-rich gas (MV-O₂) offers life-saving treatment for respiratory failure, but also promotes lung injury. We previously reported…”
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Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?
Published in American journal of physiology. Lung cellular and molecular physiology (01-01-2008)“…Prolonged mechanical ventilation (MV) with O2-rich gas inhibits lung growth and causes excess, disordered accumulation of lung elastin in preterm infants,…”
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Lung matrix and vascular remodeling in mechanically ventilated elastin haploinsufficient newborn mice
Published in American journal of physiology. Lung cellular and molecular physiology (01-03-2015)“…Elastin plays a pivotal role in lung development. We therefore queried if elastin haploinsufficient newborn mice (Eln(+/-)) would exhibit abnormal lung…”
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Molecular determinants of lung development
Published in Annals of the American Thoracic Society (01-04-2013)“…Development of the pulmonary system is essential for terrestrial life. The molecular pathways that regulate this complex process are beginning to be defined,…”
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Another Version of the Wreck of the Neva
Published in International journal of maritime history (01-05-2015)“…As 1813 dawned, Alexander Andreevich Baranov had been chief director of the Russian-American Company (RAC) since its inception in 1799. Having been in Russian…”
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Cultural Borrowings of Russians from the Natives of Alaska in the 18th and 19th Centuries
Published in International journal of cultural studies (01-07-2017)“…This article is dedicated to an analysis of Russian cultural borrowings from the Natives of Alaska and Aleutian Islands during the second half of the 18th…”
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Inhaled Nitric Oxide Effects on Lung Structure and Function in Chronically Ventilated Preterm Lambs
Published in American journal of respiratory and critical care medicine (01-10-2005)“…Inhaled nitric oxide (iNO) can reverse neonatal pulmonary hypertension and bronchoconstriction and reduce proliferation of cultured arterial and airway smooth…”
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Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease
Published in American journal of physiology. Lung cellular and molecular physiology (01-06-2007)“…Failed alveolar formation and excess, disordered elastin are key features of neonatal chronic lung disease (CLD). We previously found fewer alveoli and more…”
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Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice
Published in American journal of physiology. Lung cellular and molecular physiology (01-11-2007)“…Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice. Am…”
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Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization
Published in American journal of physiology. Lung cellular and molecular physiology (01-07-2010)“…Neonatal chronic lung disease is characterized by failed formation of alveoli and capillaries, and excessive deposition of matrix elastin, which are linked to…”
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"The Russians Are Coming": U.S.–Soviet Collaboration in the Study of the Prehistory of Beringia during the Cold War—Joint Excavations in the Aleutian Islands, 1974
Published in Arctic anthropology (01-01-2017)“…In 1974, William S. Laughlin, who had been excavating on Anangula Island, one of the earliest prehistoric sites in the Aleutian Islands, invited Aleksei P…”
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The Specific Character of Professional Statuses of Finns in Russian America
Published in Scandinavian studies (22-03-2016)Get full text
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