Search Results - "Bland, Michelle"

Regulating metabolism to shape immune function: Lessons from Drosophila by Bland, Michelle L.

“…Infection with pathogenic microbes is a severe threat that hosts manage by activating the innate immune response. In Drosophila melanogaster, the Toll and Imd…”
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Insulin signaling in development by Suzawa, Miyuki, Bland, Michelle L

“…Nutrient intake is obligatory for animal growth and development, but nutrients alone are not sufficient. Indeed, insulin and homologous hormones are required…”
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Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function by Martínez, Brittany A, Hoyle, Rosalie G, Yeudall, Scott, Granade, Mitchell E, Harris, Thurl E, Castle, J David, Leitinger, Norbert, Bland, Michelle L

“…During infection, cellular resources are allocated toward the metabolically-demanding processes of synthesizing and secreting effector proteins that neutralize…”
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Dilp-2-mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche by Yuan, Xin, Sipe, Conor W, Suzawa, Miyuki, Bland, Michelle L, Siegrist, Sarah E

“…Dietary nutrients provide macromolecules necessary for organism growth and development. In response to animal feeding, evolutionarily conserved growth…”
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immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling by DiAngelo, Justin R, Bland, Michelle L, Bambina, Shelly, Cherry, Sara, Birnbaum, Morris J

“…Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection against a foreign organism is…”
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The Toll Signaling Pathway Targets the Insulin-like Peptide Dilp6 to Inhibit Growth in Drosophila by Suzawa, Miyuki, Muhammad, Nigel M., Joseph, Bradley S., Bland, Michelle L.

“…Chronic enteropathogen infection in early childhood reduces circulating insulin-like growth factor 1 (IGF1) levels and restricts growth. Pathogen-derived…”
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Synchronizing Drosophila larvae with the salivary gland reporter Sgs3-GFP for discovery of phenotypes in the late third instar stage by McPherson, W. Kyle, Van Gorder, Elizabeth E., Hilovsky, Dalton L., Jamali, Leila A., Keliinui, Cami N., Suzawa, Miyuki, Bland, Michelle L.

“…The larval stage of the Drosophila melanogaster life cycle is characterized by rapid growth and nutrient storage that occur over three instar stages separated…”
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Correction: Dilp-2–mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche by Yuan, Xin, Sipe, Conor W., Suzawa, Miyuki, Bland, Michelle L., Siegrist, Sarah E.

“…[This corrects the article DOI: 10.1371/journal.pbio.3000721.]…”
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Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P 3 Production and Akt Activation by Roth, Stephen W, Bitterman, Moshe D, Birnbaum, Morris J, Bland, Michelle L

“…In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila…”
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Adipocyte lipolysis drives acute stress-induced insulin resistance by Raje, Vidisha, Ahern, Katelyn W., Martinez, Brittany A., Howell, Nancy L., Oenarto, Vici, Granade, Mitchell E., Kim, Jae Woo, Tundup, Smanla, Bottermann, Katharina, Gödecke, Axel, Keller, Susanna R., Kadl, Alexandra, Bland, Michelle L., Harris, Thurl E.

“…Stress hyperglycemia and insulin resistance are evolutionarily conserved metabolic adaptations to severe injury including major trauma, burns, or hemorrhagic…”
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Measurement of Carbon Dioxide Production from Radiolabeled Substrates in Drosophila melanogaster by Bland, Michelle L

“…The power of Drosophila genetics is increasingly being applied to questions of hormone signaling and metabolism and to the development of models of human…”
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427 Defining the Impact of the Fecal Microbiome and Secretome on Multiple System Atrophy and α-Synuclein Aggregation by Bland, Michelle K., Singer, Wolfgang, Walther-António, Marina R. S.

“…OBJECTIVES/GOALS: Aim 1: We will determine whether temporal changes in the fecal microbiome signature correlate with a clinical multiple system atrophy (MSA)…”
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Do Social Support and Loneliness Influence Emerging Adults' Mental Health during the First Year of the COVID-19 Pandemic? by Jensen-Campbell, Lauri A, Liegey Dougall, Angela, Heller, Abigail C, Iyer-Eimerbrink, Priya, Bland, Michelle K, Hull, Kristen

“…Youths' mental health is at a crisis level, with mental health problems doubling in the US since the pandemic began. To compound the mental health crisis,…”
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Considerations in addressing the opioid epidemic and chronic pain within the USA by Marshall, Blaine, Bland, Michelle K, Hulla, Ryan, Gatchel, Robert J

“…This article reviews the complexities of the opioid epidemic, considering recent research involving the current state of the opioid epidemic; chronic pain and…”
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Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation by Roth, Stephen W., Bitterman, Moshe D., Birnbaum, Morris J., Bland, Michelle L.

“…In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila…”
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Pregabalin and hyperbaric oxygen therapy on pain thresholds and anxio-depressive behaviors in a preclinical fibromyalgia pain model by Argenbright, Cassie M, Bland, Michelle K, Michener, Sydney L, Wilson, Judy R, Fuchs, Perry N

“…Fibromyalgia (FM) is a chronic, widespread pain disorder generally of a non-inflammatory nature with many known affective and cognitive comorbidities. There is…”
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ADaPting to Energetic Stress by Bland, Michelle L., Birnbaum, Morris J.

“…What is the true activator of a key enzyme that controls cell energetics? The movement of muscles, the repolarization of neuronal membranes, and the synthesis…”
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AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut by Bland, Michelle L., Lee, Robert J., Magallanes, Julie M., Foskett, J. Kevin, Birnbaum, Morris J.

“…The larval phase of the Drosophila life cycle is characterized by constant food intake, resulting in a two hundred-fold increase in mass over four days. Here…”
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Differential Requirement for Steroidogenic Factor-1 Gene Dosage in Adrenal Development Versus Endocrine Function by Bland, Michelle L, Fowkes, Robert C, Ingraham, Holly A

“…The importance of steroidogenic factor-1 (SF-1) gene dosage in endocrine function is evidenced by phenotypes associated with the heterozygous state in mice and…”
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Haploinsufficiency of Steroidogenic Factor-1 in Mice Disrupts Adrenal Development Leading to an Impaired Stress Response by Bland, M L, Jamieson, C A, Akana, S F, Bornstein, S R, Eisenhofer, G, Dallman, M F, Ingraham, H A

“…Adrenal steroids are essential for homeostasis and survival during severe physiological stress. Analysis of a patient heterozygous for the steroidogenic…”
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