Search Results - "Blanco, C.G."

A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology by Blanco, Jorge C.G, Boukhvalova, Marina S, Pletneva, Lioubov M, Shirey, Kari Ann, Vogel, Stefanie N

“…Highlights • Developed a recombinant RSV F-protein based subunit vaccine formulated with monophosphoryl lipid A (MPL). • Vaccine reduced lung viral replication…”
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On the pyrolysis of sewage sludge: the influence of pyrolysis conditions on solid, liquid and gas fractions by Inguanzo, M, Domı́nguez, A, Menéndez, J.A, Blanco, C.G, Pis, J.J

“…The pyrolysis of a sewage sludge, produced by a Spanish urban wastewater treatment plant, was carried out in a laboratory furnace. Pyrolysis conditions, like…”
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Biomarkers in a peat deposit in Northern Spain (Huelga de Bayas, Asturias) as proxy for climate variation by López-Días, V., Borrego, Á.G., Blanco, C.G., Arboleya, M., López-Sáez, J.A., López-Merino, L.

“…Peatlands are peculiar ecosystems in which well-adapted communities grow and develop, recording the variation in climate and hydrological conditions inland. In…”
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Effect of aging on immunogenicity and efficacy of inactivated influenza vaccines in cotton rats Sigmodon hispidus by Boukhvalova, Marina S., Mortensen, Emma, Mbaye, Aissatou, McKay, Jamall, Blanco, Jorge C.G.

“…Inactivated influenza vaccines are known to be less immunogenic in human elderly in regards to serologic antibody response induced by vaccination. Accumulating…”
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The cotton rat model of respiratory viral infections by Boukhvalova, Marina S., Prince, Gregory A., Blanco, Jorge C.G.

“…Development of successful vaccines against human infectious diseases depends on using appropriate animal models for testing vaccine efficacy and safety. For…”
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The histone acetylase PCAF is a nuclear receptor coactivator by Blanco, J C, Minucci, S, Lu, J, Yang, X J, Walker, K K, Chen, H, Evans, R M, Nakatani, Y, Ozato, K

“…Whereas the histone acetylase PCAF has been suggested to be part of a coactivator complex mediating transcriptional activation by the nuclear hormone…”
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Novel strategies for targeting innate immune responses to influenza by Shirey, K A, Lai, W, Patel, M C, Pletneva, L M, Pang, C, Kurt-Jones, E, Lipsky, M, Roger, T, Calandra, T, Tracey, K J, Al-Abed, Y, Bowie, A G, Fasano, A, Dinarello, C A, Gusovsky, F, Blanco, J C G, Vogel, S N

“…We previously reported that TLR4 −/− mice are refractory to mouse-adapted A/PR/8/34 (PR8) influenza-induced lethality and that therapeutic administration of…”
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Control of RSV-induced lung injury by alternatively activated macrophages is IL-4Rα-, TLR4-, and IFN-β-dependent by Shirey, K A, Pletneva, L M, Puche, A C, Keegan, A D, Prince, G A, Blanco, J C G, Vogel, S N

“…Severe respiratory syncytial virus (RSV)-induced bronchiolitis has been associated with a mixed “Th1” and “Th2” cytokine storm. We hypothesized that…”
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Preclinical assessment of safety of maternal vaccination against respiratory syncytial virus (RSV) in cotton rats by Blanco, Jorge C.G, Pletneva, Lioubov M, Otoa, Raymonde O, Patel, Mira C, Vogel, Stefanie N, Boukhvalova, Marina S

“…Abstract Maternal immunization directed to control RSV infection in newborns and infants is an appealing vaccination strategy currently under development. In…”
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Maternal transfer of RSV immunity in cotton rats vaccinated during pregnancy by Blanco, Jorge C.G, Pletneva, Lioubov M, Oue, Raymonde O, Patel, Mira C, Boukhvalova, Marina S

“…Abstract Respiratory Syncytial Virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants, resulting in significant morbidity and mortality…”
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Interferon-inducible Mx gene expression in cotton rats: cloning, characterization, and expression during influenza viral infection by Pletneva, Lioubov M, Haller, Otto, Porter, David D, Prince, Gregory A, Blanco, Jorge C G

“…Mx proteins belong to the superfamily of large GTPases with antiviral activity against a wide range of RNA viruses. In vivo, the expression of Mx genes is…”
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Comparisons of Antibody Populations in Different Pre-Fusion F VLP-Immunized Cotton Rat Dams and Their Offspring by Cullen, Lori M, Boukhvalova, Marina S, Blanco, Jorge C G, Morrison, Trudy G

“…Respiratory syncytial virus (RSV) infection poses a significant risk for infants. Since the direct vaccination of infants is problematic, maternal vaccination…”
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Chronic helminth infection does not exacerbate Mycobacterium tuberculosis infection by Hübner, Marc P, Killoran, Kristin E, Rajnik, Michael, Wilson, Samuel, Yim, Kevin C, Torrero, Marina N, Morris, Christopher P, Nikonenko, Boris, Blanco, Jorge C G, Hemming, Val G, Mitre, Edward

“…Chronic helminth infections induce a Th2 immune shift and establish an immunoregulatory milieu. As both of these responses can suppress Th1 immunity, which is…”
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Human metapneumovirus: Enhanced pulmonary disease in cotton rats immunized with formalin-inactivated virus vaccine and challenged by Yim, Kevin C, Cragin, Rose P, Boukhvalova, Marina S, Blanco, Jorge C.G, Hamlin, Marie-Ève, Boivin, Guy, Porter, David D, Prince, Gregory A

“…Abstract Cotton rats ( Sigmodon hispidus ) are susceptible to the recently discovered human metapneumovirus (hMPV), an agent closely related to human…”
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Activation of interferon response through toll-like receptor 3 impacts viral pathogenesis and pulmonary toll-like receptor expression during respiratory syncytial virus and influenza infections in the cotton rat Sigmodon hispidus model by Boukhvalova, Marina S, Sotomayor, Talia B, Point, Ryan C, Pletneva, Lioubov M, Prince, Gregory A, Blanco, Jorge C G

“…Interferon (IFN) therapy in humans often causes flu-like symptoms by an unknown mechanism. Poly ICLC is a synthetic dsRNA and a Toll-like receptor 3 (TLR3)…”
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Maceral composition and molecular markers of two condensed Middle Holocene peat profiles in N Spain by López-Días, V., Urbańczyk, J., Blanco, C.G., Borrego, Á.G.

“…This study deals with the palaeohydrological information obtained from lipids composition and vegetal tissue preservation of two peat cores from Asturias,…”
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Biomarkers as paleoclimate proxies in peatlands in coastal high plains in Asturias, N Spain by López-Días, V., Urbanczyk, J., Blanco, C.G., Borrego, A.G.

“…This study represents an attempt to correlate wet and dry episodes as defined by biomarker parameters in peat profiles of Asturias (North Spain). The peats…”
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The Pliensbachian (Early Jurassic) “anoxic” event in Asturias, northern Spain: Santa Mera Member, Rodiles Formation by Borrego, A.G., Hagemann, H.W., Blanco, C.G., Valenzuela, M., Suárez de Centi, C.

“…The Pliensbachian rhythmite of Asturias (Northern Spain) consists of alternating layers of limestone and marl of postdepositional origin. The sediments are…”
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The American cotton rat: A novel model for pulmonary tuberculosis by Elwood, Robert L, Wilson, Samuel, Blanco, Jorge C.G, Yim, Kevin, Pletneva, Luba, Nikonenko, Boris, Samala, Rowena, Joshi, Swati, Hemming, Val G, Trucksis, Michele

“…Summary Several animal models are used to study Mycobacterium tuberculosis (MTB) infections, but none is a fully ideal model of human disease. The American…”
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Characterization of late tuberculosis infection in Sigmodon hispidus by Elwood, Robert L, Rajnik, Michael, Wilson, Samuel, Yim, Kevin, Blanco, Jorge C.G, Nikonenko, Boris, Hemming, Val G

“…Summary We previously described primary tuberculosis in Sigmodon hispidus cotton rats up to 6 months following a pulmonary challenge. At that time, we observed…”
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