Examining post‐donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review
We conducted a systematic review to assess outcomes in Hispanic donors and explore how Hispanic ethnicity was characterized. We searched PubMed, EMBASE, and Scopus through October 2021. Two reviewers independently screened study titles, s, and full texts; they also qualitatively synthesized results...
Saved in:
| Published in: | American journal of transplantation Vol. 22; no. 7; pp. 1737 - 1753 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Limited
01-07-2022
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | We conducted a systematic review to assess outcomes in Hispanic donors and explore how Hispanic ethnicity was characterized. We searched PubMed, EMBASE, and Scopus through October 2021. Two reviewers independently screened study titles, s, and full texts; they also qualitatively synthesized results and independently assessed quality of included studies. Eighteen studies met our inclusion criteria. Study sample sizes ranged from 4007 to 143,750 donors and mean age ranged from 37 to 54 years. Maximum follow‐up time of studies varied from a perioperative donor nephrectomy period to 30 years post‐donation. Hispanic donors ranged between 6% and 21% of the donor populations across studies. Most studies reported Hispanic ethnicity under race or a combined race and ethnicity category. Compared to non‐Hispanic White donors, Hispanic donors were not at increased risk for post‐donation mortality, end‐stage kidney disease, cardiovascular disease, non‐pregnancy‐related hospitalizations, or overall perioperative surgical complications. Compared to non‐Hispanic White donors, most studies showed Hispanic donors were at higher risk for diabetes mellitus following nephrectomy; however, mixed findings were seen regarding the risk for post‐donation chronic kidney disease and hypertension. Future studies should evaluate cultural, socioeconomic, and geographic differences within the heterogeneous Hispanic donor population, which may further explain variation in health outcomes.
Hispanic compared to non‐Hispanic living kidney donors are not at increased risk for post‐donation mortality, end‐stage kidney disease, cardiovascular disease, non‐pregnancy‐related hospitalizations, or perioperative surgical complications, but are at higher risk of post‐donation diabetes. |
|---|---|
| Bibliography: | Funding information Dr. Alvarado was supported, in part, by grant 2T32DK773226 from the National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK). Dr. Crews was supported, in part, by grant 1K24HL148181 from the NIH/National Heart, Lung, and Blood Institute. Dr. Al Ammary was supported, in part, by grant K23DK129820 from the NIH/NIDDK. Dr. Purnell was supported, in part, by grant K01HS024600 from the Agency for Healthcare Research and Quality (AHRQ). The NIH and AHRQ had no role in the preparation, review, or approval of the manuscript or the decision to submit for publication. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Undefined-4 |
| ISSN: | 1600-6135 1600-6143 1600-6143 |
| DOI: | 10.1111/ajt.17017 |