Search Results - "Blanchette, Craig"

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines by Tahtinen, Siri, Tong, Ann-Jay, Himmels, Patricia, Oh, Jaehak, Paler-Martinez, Andres, Kim, Leesun, Wichner, Sara, Oei, Yoko, McCarron, Mark J., Freund, Emily C., Amir, Zhainib Adel, de la Cruz, Cecile C., Haley, Benjamin, Blanchette, Craig, Schartner, Jill M., Ye, Weilan, Yadav, Mahesh, Sahin, Ugur, Delamarre, Lélia, Mellman, Ira

“…The use of lipid-formulated RNA vaccines for cancer or COVID-19 is associated with dose-limiting systemic inflammatory responses in humans that were not…”
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Transposable element expression in tumors is associated with immune infiltration and increased antigenicity by Kong, Yu, Rose, Christopher M., Cass, Ashley A., Williams, Alexander G., Darwish, Martine, Lianoglou, Steve, Haverty, Peter M., Tong, Ann-Jay, Blanchette, Craig, Albert, Matthew L., Mellman, Ira, Bourgon, Richard, Greally, John, Jhunjhunwala, Suchit, Chen-Harris, Haiyin

“…Profound global loss of DNA methylation is a hallmark of many cancers. One potential consequence of this is the reactivation of transposable elements (TEs)…”
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Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses by Anikeeva, Nadia, Fischer, Nicholas O, Blanchette, Craig D, Sykulev, Yuri

“…MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering…”
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SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury by Chang, Jiun C, Christiansen, Blaine A, Murugesh, Deepa K, Sebastian, Aimy, Hum, Nicholas R, Collette, Nicole M, Hatsell, Sarah, Economides, Aris N, Blanchette, Craig D, Loots, Gabriela G

“…ABSTRACT Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are…”
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Printable enzyme-embedded materials for methane to methanol conversion by Blanchette, Craig D., Knipe, Jennifer M., Stolaroff, Joshuah K., DeOtte, Joshua R., Oakdale, James S., Maiti, Amitesh, Lenhardt, Jeremy M., Sirajuddin, Sarah, Rosenzweig, Amy C., Baker, Sarah E.

“…An industrial process for the selective activation of methane under mild conditions would be highly valuable for controlling emissions to the environment and…”
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Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform by Fischer, Nicholas O, Weilhammer, Dina R, Dunkle, Alexis, Thomas, Cynthia, Hwang, Mona, Corzett, Michele, Lychak, Cheri, Mayer, Wasima, Urbin, Salustra, Collette, Nicole, Chiun Chang, Jiun, Loots, Gabriela G, Rasley, Amy, Blanchette, Craig D

“…Nanoparticles hold great promise for the delivery of therapeutics, yet limitations remain with regards to the use of these nanosystems for efficient…”
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Colocalized Delivery of Adjuvant and Antigen Using Nanolipoprotein Particles Enhances the Immune Response to Recombinant Antigens by Fischer, Nicholas O, Rasley, Amy, Corzett, Michele, Hwang, Mona H, Hoeprich, Paul D, Blanchette, Craig D

“…Subunit antigen-based vaccines can provide a number of important benefits over traditional vaccine candidates, such as overall safety. However, because of the…”
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AFM for structure and dynamics of biomembranes by Goksu, Emel I., Vanegas, Juan M., Blanchette, Craig D., Lin, Wan-Chen, Longo, Marjorie L.

“…We review structure and dynamic measurements of biomembranes by atomic force microscopy (AFM). We focus mainly on studies involving supported lipid bilayers…”
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Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye by Shatz, Whitney, Hass, Philip E, Peer, Nikhil, Paluch, Maciej T, Blanchette, Craig, Han, Guanghui, Sandoval, Wendy, Morando, Ashley, Loyet, Kelly M, Bantseev, Vladimir, Booler, Helen, Crowell, Susan, Kamath, Amrita, Scheer, Justin M, Kelley, Robert F

“…Innovative protein engineering and chemical conjugation technologies have yielded an impressive number of drug candidates in clinical development including >80…”
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Cell-free production of a functional oligomeric form of a Chlamydia major outer-membrane protein (MOMP) for vaccine development by He, Wei, Felderman, Martina, Evans, Angela C., Geng, Jia, Homan, David, Bourguet, Feliza, Fischer, Nicholas O., Li, Yuanpei, Lam, Kit S., Noy, Aleksandr, Xing, Li, Cheng, R. Holland, Rasley, Amy, Blanchette, Craig D., Kamrud, Kurt, Wang, Nathaniel, Gouvis, Heather, Peterson, Todd C., Hubby, Bolyn, Coleman, Matthew A.

“…Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia…”
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Lipid Asymmetry in DLPC/DSPC-Supported Lipid Bilayers: A Combined AFM and Fluorescence Microscopy Study by Lin, Wan-Chen, Blanchette, Craig D., Ratto, Timothy V., Longo, Marjorie L.

“…A fundamental attribute of cell membranes is transmembrane asymmetry, specifically the formation of ordered phase domains in one leaflet that are…”
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Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles by Coleman, Matthew A, Cappuccio, Jenny A, Blanchette, Craig D, Gao, Tingjuan, Arroyo, Erin S, Hinz, Angela K, Bourguet, Feliza A, Segelke, Brent, Hoeprich, Paul D, Huser, Thomas, Laurence, Ted A, Motin, Vladimir L, Chromy, Brett A

“…Yersinia pestis enters host cells and evades host defenses, in part, through interactions between Yersinia pestis proteins and host membranes. One such…”
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Enhancement of antigen-specific CD4+ and CD8+ T cell responses using a self-assembled biologic nanolipoprotein particle vaccine by Weilhammer, Dina, Dunkle, Alexis D, Blanchette, Craig D, Fischer, Nicholas O, Corzett, Michele, Lehmann, Doerte, Boone, Tyler, Hoeprich, Paul, Driks, Adam, Rasley, Amy

“…Highlights • The model antigen OVA was covalently conjugated to nanolipoprotein particles (NLPs). • NLP conjugation enhanced uptake of OVA by antigen…”
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Enhanced cellulose degradation using cellulase-nanosphere complexes by Blanchette, Craig, Lacayo, Catherine I, Fischer, Nicholas O, Hwang, Mona, Thelen, Michael P

“…Enzyme catalyzed conversion of plant biomass to sugars is an inherently inefficient process, and one of the major factors limiting economical biofuel…”
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Lipid composition dictates serum stability of reconstituted high-density lipoproteins: implications for in vivo applications by Gilmore, Sean F, Carpenter, Timothy S, Ingólfsson, Helgi I, Peters, Sandra K G, Henderson, Paul T, Blanchette, Craig D, Fischer, Nicholas O

“…Nanolipoprotein particles (NLPs) are reconstituted high-density lipoproteins, consisting of a phospholipid bilayer stabilized by an apolipoprotein scaffold…”
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Conjugation to Nickel-Chelating Nanolipoprotein Particles Increases the Potency and Efficacy of Subunit Vaccines to Prevent West Nile Encephalitis by Fischer, Nicholas O, Infante, Ernesto, Ishikawa, Tomohiro, Blanchette, Craig D, Bourne, Nigel, Hoeprich, Paul D, Mason, Peter W

“…Subunit antigens are attractive candidates for vaccine development, as they are safe, cost-effective, and rapidly produced. Nevertheless, subunit antigens…”
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Decoupling internalization, acidification and phagosomal-endosomal/lysosomal fusion during phagocytosis of InlA coated beads in epithelial cells by Blanchette, Craig D, Woo, Youn-Hi, Thomas, Cynthia, Shen, Nan, Sulchek, Todd A, Hiddessen, Amy L

“…Phagocytosis has been extensively examined in 'professional' phagocytic cells using pH sensitive dyes. However, in many of the previous studies, a separation…”
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Characterization of Bacillus anthracis Spore Proteins Using a Nanoscaffold Vaccine Platform by Weilhammer, Dina R, Dunkle, Alexis D, Boone, Tyler, Gilmore, Sean F, Khemmani, Mark, Peters, Sandra K G, Hoeprich, Paul D, Fischer, Nicholas O, Blanchette, Craig D, Driks, Adam, Rasley, Amy

“…Subunit vaccines are theoretically safe and easy to manufacture but require effective adjuvants and delivery systems to yield protective immunity, particularly…”
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The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge by Weilhammer, Dina R, Blanchette, Craig D, Fischer, Nicholas O, Alam, Shabnam, Loots, Gabriela G, Corzett, Michele, Thomas, Cynthia, Lychak, Cheri, Dunkle, Alexis D, Ruitenberg, Joyce J, Ghanekar, Smita A, Sant, Andrea J, Rasley, Amy

“…Abstract Recent studies have demonstrated that therapies targeting the innate immune system have the potential to provide transient, non-specific protection…”
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Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer by Coffey, David G., Xu, Yuexin, Towlerton, Andrea M. H., Kowanetz, Marcin, Hegde, Priti, Darwish, Martine, Yadav, Mahesh, Blanchette, Craig, Ruppert, Shannon M., Bertino, Sarah, Xu, Qikai, Ferretti, Andrew, Weinheimer, Adam, Hellmann, Matthew, Qin, Angel, Thomas, Dafydd, Warren, Edus H., Ramnath, Nithya

“…Most patients with advanced non-small cell lung cancer (NSCLC) do not achieve a durable remission after treatment with immune checkpoint inhibitors. Here we…”
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