Search Results - "Blanchard, J.C."

Creation and piloting of a new hospital capacity assessment tool in a major urban area by Siegel, B, Norton, B.L, Blanchard, J.C, Regenstein, M, Jones, K.C

“…Summary Objectives Crowded hospital emergency departments (EDs) can undermine the ability of a region's safety net to provide safe, timely care. However, data…”
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Pertussis toxin pretreatment abolishes the inhibitory effect of riluzole and carbachol on D-[3H]aspartate release from cultured cerebellar granule cells by Doble, A, Hubert, J P, Blanchard, J C

“…The release of D-[3H]aspartate from cultured cerebellar granule cells evoked by glutamic acid can be inhibited by riluzole and the muscarinic agonist…”
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A non‐peptide NK1‐receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically by Moussaoui, S.M., Montier, F., Carruette, A., Blanchard, J.C., Laduron, P.M., Garret, C.

“…1 The non‐peptide neurokinin NK1‐receptor antagonist, RP 67580 (3aR, 7a), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind…”
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Cardiopulmonary exercise testing combined with echocardiography and response after a cardiac rehabilitation program in chronic heart failure patients by Vitiello, D., Moatemri, F., Lamar-Tanguy, A., Kovalska, O., Blanchard, J.C., Ledru, F., Cristofini, P., Iliou, M.

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Differential ability of tachykinin NK-1 and NK-2 agonists to produce scratching and grooming behaviours in mice by Ravard, S, Betschart, J, Fardin, V, Flamand, O, Blanchard, J C

“…Potent and selective NK-1 and NK-2 agonists as well as compounds with lower selectivity and affinity for NK-1 binding sites were compared in their ability to…”
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Pharmacological characterization of RP 62203, a novel 5‐hydroxytryptamine 5‐HT2 receptor antagonist by Doble, A., Girdlestone, D., Piot, O., Allam, D., Betschart, J., Boireau, A., Dupuy, A., Guérémy, C., Ménager, J., Zundel, J.L., Blanchard, J.C.

“…1 RP 62203 (2‐[3‐(4‐(4‐fluorophenyl)‐piperazinyl)propyl]naphto[1,8‐cd]isothiazole‐1,1‐dioxide) is a novel naphtosultam derivative which shows very high…”
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Are 5-HT2 antagonists endowed with anxiolytic properties in rodents? by Stutzmann, J M, Eon, B, Darche, F, Lucas, M, Rataud, J, Piot, O, Blanchard, J C, Laduron, P M

“…The precise role of serotonin (5-HT) in anxiety remains unclear. We report here on the effects of RP 62203, a new 5-HT2 antagonist, and ritanserin in different…”
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A non‐peptide NK 1 ‐receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically by Moussaoui, S.M., Montier, F., Carruette, A., Blanchard, J.C., Laduron, P.M., Garret, C.

“…The non‐peptide neurokinin NK 1 ‐receptor antagonist, RP 67580 (3aR, 7a), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind…”
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Cyclic Cholecystokinin Analogues with High Selectivity for Central Receptors by Charpentier, Bruno, Pelaprat, Didier, Durieux, Christiane, Dor, Adeline, Reibaud, Michel, Blanchard, Jean-Charles, Roques, Bernard P.

“…Taking as a model the N-terminal folding of the cholecystokinin tyrosine-sulfated octapeptide [CCK-8; Asp-Tyr-(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH$_{2}$] deduced…”
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Neurotensin effects on evoked release of dopamine in slices from striatum, nucleus accumbens and prefrontal cortex in rat by HETIER, E, BOIREAU, A, DUBEDAT, P, BLANCHARD, J. C

“…The effects of neurotensin (NT) on the K+-evoked release of endogenous and tritiated dopamine in striatum and on 3H-dopamine in slices from nucleus accumbens…”
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The selective CCK-B agonist, BC 264 injected in the antero-lateral part of the nucleus accumbens, reduces the spontaneous alternation behaviour of rats by Daugé, V, Derrien, M, Blanchard, J C, Roques, B P

“…The aim of this study was to examine the behavioural effects induced by stimulation of CCK receptors in the nucleus accumbens of the rat, which contains a high…”
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Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice by Piot, O, Betschart, J, Stutzmann, J M, Blanchard, J C

“…In a model of physical dependence in mice, treatment with cyclopyrrolones such as zopiclone and suriclone (from 4 to 400 mg/kg/day), did not modify the…”
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Pharmacological and clinical studies of cyclopyrrolones: zopiclone and suriclone by Julou, L, Blanchard, J C, Dreyfus, J F

“…Among the non-benzodiazepine compounds which have been found to interact with the "GABA receptor-BZ receptor-chloride channel complex," the very chemically…”
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Pharmacological characterization of RP 62203, a novel 5‐hydroxytryptamine 5‐HT 2 receptor antagonist by Doble, A., Girdlestone, D., Piot, O., Allam, D., Betschart, J., Boireau, A., Dupuy, A., Guérémy, C., Ménager, J., Zundel, J.L., Blanchard, J.C.

“…RP 62203 (2‐[3‐(4‐(4‐fluorophenyl)‐piperazinyl)propyl]naphto[1,8‐cd]isothiazole‐1,1‐dioxide) is a novel naphtosultam derivative which shows very high affinity…”
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Riluzole, a glutamate antagonist, enhances slow wave and REM sleep in rats by Stutzmann, J M, Lucas, M, Blanchard, J C, Laduron, P M

“…Riluzole is a drug that interferes with glutamate neurotransmitters. We studied the sleep pattern of rats treated orally with riluzole at doses ranging from…”
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Reduction of the amount of neurotensin retrogradely transported in dopaminergic neurons of senescent rats by Castel, M N, Lechardeur, D, Blanchard, J C, Laduron, P M

“…It is now clearly established that fast anterograde axonal transport can be altered during ageing, both in the central and the peripheral nervous systems, but…”
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In vivo determination of the profile of benzodiazepine ligands by comparing the inhibition of 3H-Ro 15-1788 binding to the modulation of cGMP levels in mouse cerebellum by Boireau, A, Martel, M, Farges, G, Dubédat, P, Laduron, P M, Blanchard, J C

“…The in vivo effects of various benzodiazepine (BZD) ligands belonging to different chemical families were studied comparatively in mouse cerebellum using…”
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Partial chemical characterization of cyclopyrrolones ([3H] suriclone) and benzodiazepines ([3H]flunitrazepam) binding site: differences by Zundel, J L, Blanchard, J C, Julou, L

“…Rat hippocampus membranes were treated with several protein modifying reagents (iodoacetamide, N-ethylmaleimide, tetranitromethane and N-acetylimidazole). The…”
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Brain receptors and zopiclone by Blanchard, J C, Boireau, A, Julou, L

“…Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man…”
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Pharmacological studies on zopiclone by Julou, L, Bardone, M C, Blanchard, J C, Garret, C, Stutzmann, J M

“…Zopiclone (RP 27 267) is an hypnotic with a chemical structure different from that of the benzodiazepines (BZD) or barbiturates. Studies of zopiclone in…”
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