Search Results - "Blanchard, Guy B"

Actomyosin-Driven Tension at Compartmental Boundaries Orients Cell Division Independently of Cell Geometry In Vivo by Scarpa, Elena, Finet, Cédric, Blanchard, Guy B., Sanson, Bénédicte

“…Cell shape is known to influence the plane of cell division. In vitro, mechanical constraints can also orient mitoses; however, in vivo it is not clear whether…”
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Mechanical Coupling between Endoderm Invagination and Axis Extension in Drosophila by Lye, Claire M, Blanchard, Guy B, Naylor, Huw W, Muresan, Leila, Huisken, Jan, Adams, Richard J, Sanson, Bénédicte

“…How genetic programs generate cell-intrinsic forces to shape embryos is actively studied, but less so how tissue-scale physical forces impact morphogenesis…”
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Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model by Nestor-Bergmann, Alexander, Blanchard, Guy B, Hervieux, Nathan, Fletcher, Alexander G, Étienne, Jocelyn, Sanson, Bénédicte

“…Cell intercalation is a key cell behaviour of morphogenesis and wound healing, where local cell neighbour exchanges can cause dramatic tissue deformations such…”
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Dynamics of actomyosin contractile activity during epithelial morphogenesis by Gorfinkiel, Nicole, Blanchard, Guy B

“…Highlights ► A pulsatile medial actomyosin network drives cell area fluctuations. ► Higher pulse frequencies are required for effective cell contraction. ►…”
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Polarised cell intercalation during Drosophila axis extension is robust to an orthogonal pull by the invaginating mesoderm by Lye, Claire M, Blanchard, Guy B, Evans, Jenny, Nestor-Bergmann, Alexander, Sanson, Bénédicte

“…As tissues grow and change shape during animal development, they physically pull and push on each other, and these mechanical interactions can be important for…”
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The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension by Finegan, Tara M, Hervieux, Nathan, Nestor-Bergmann, Alexander, Fletcher, Alexander G, Blanchard, Guy B, Sanson, Bénédicte

“…In epithelia, tricellular vertices are emerging as important sites for the regulation of epithelial integrity and function. Compared to bicellular contacts,…”
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A Dynamic Microtubule Cytoskeleton Directs Medial Actomyosin Function during Tube Formation by Booth, Alexander J.R., Blanchard, Guy B., Adams, Richard J., Röper, Katja

“…The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin…”
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Radially patterned cell behaviours during tube budding from an epithelium by Sanchez-Corrales, Yara E, Blanchard, Guy B, Röper, Katja

“…The budding of tubular organs from flat epithelial sheets is a vital morphogenetic process. Cell behaviours that drive such processes are only starting to be…”
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Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation by Fierling, Julien, John, Alphy, Delorme, Barthélémy, Torzynski, Alexandre, Blanchard, Guy B., Lye, Claire M., Popkova, Anna, Malandain, Grégoire, Sanson, Bénédicte, Étienne, Jocelyn, Marmottant, Philippe, Quilliet, Catherine, Rauzi, Matteo

“…Cell apical constriction driven by actomyosin contraction forces is a conserved mechanism during tissue folding in embryo development. While much is now…”
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Geometry can provide long-range mechanical guidance for embryogenesis by Dicko, Mahamar, Saramito, Pierre, Blanchard, Guy B, Lye, Claire M, Sanson, Bénédicte, Étienne, Jocelyn

“…Downstream of gene expression, effectors such as the actomyosin contractile machinery drive embryo morphogenesis. During Drosophila embryonic axis extension,…”
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Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation by Mahadevan, L, Adams, Richard J, Blanchard, Guy B, Kabla, Alexandre J, Schultz, Nora L, Butler, Lucy C, Sanson, Benedicte, Gorfinkiel, Nicole

“…As tissues mature, they undergo shape changes that are the result of individual and collective cell movement triggered by cell-autonomous behavior or external…”
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Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension by Tetley, Robert J, Blanchard, Guy B, Fletcher, Alexander G, Adams, Richard J, Sanson, Bénédicte

“…Convergence and extension movements elongate tissues during development. Drosophila germ-band extension (GBE) is one example, which requires active cell…”
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Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension by Welchman, David P, Blanchard, Guy B, Lawrence, Nicola J, Kabla, Alexandre J, Mahadevan, L, Butler, Lucy C, Adams, Richard J, Sanson, Benedicte

“…Drosophila germ-band extension (GBE) is an example of the convergence and extension movements that elongate and narrow embryonic tissues. To understand the…”
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Correct regionalization of a tissue primordium is essential for coordinated morphogenesis by Sánchez-Corrales, Yara E, Blanchard, Guy B, Röper, Katja

“…During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the embryo,…”
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Mechanical control of global cell behaviour during dorsal closure in Drosophila by Gorfinkiel, Nicole, Blanchard, Guy B, Adams, Richard J, Martinez Arias, Alfonso

“…Halfway through embryonic development, the epidermis of Drosophila exhibits a gap at the dorsal side covered by an extraembryonic epithelium, the amnioserosa…”
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Emergent material properties of developing epithelial tissues by Machado, Pedro F, Duque, Julia, Étienne, Jocelyn, Martinez-Arias, Alfonso, Blanchard, Guy B, Gorfinkiel, Nicole

“…Force generation and the material properties of cells and tissues are central to morphogenesis but remain difficult to measure in vivo. Insight is often…”
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Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics by Fischer, Sabine C, Blanchard, Guy B, Duque, Julia, Adams, Richard J, Arias, Alfonso Martinez, Guest, Simon D, Gorfinkiel, Nicole

“…Mechanics has an important role during morphogenesis, both in the generation of forces driving cell shape changes and in determining the effective material…”
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A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia by England, Samantha J, Blanchard, Guy B, Mahadevan, L, Adams, Richard J

“…Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex reorganisation of the forebrain neural…”
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Taking the strain: quantifying the contributions of all cell behaviours to changes in epithelial shape by Blanchard, Guy B.

“…Computer-assisted tracking of the shapes of many cells over long periods of development has driven the exploration of novel ways to quantify the contributions…”
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A 3D cell shape found in sheets and tubes by Blanchard, Guy B

“…[...]in the current model, the authors used 2D modelling of the inner and outer surfaces of cells to infer 3D cell shapes - predictions might differ if…”
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