Search Results - "Blanchard, Andrew P"

Substrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates by STRESSER, David M, BLANCHARD, Andrew P, TURNER, Stephanie D, ERVE, John C. L, DANDENEAU, Andre A, MILLER, Vaughn P, CRESPI, Charles L

“…Inhibition of cytochrome P450 catalytic activity is a principal mechanism for pharmacokinetic drug-drug interactions. Rapid, in vitro testing for cytochrome…”
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HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE by STRESSER, David M, BROUDY, Marc I, PATTEN, Christopher J, DEHAL, Shangara S, CRESPI, Charles L, THUY HO, CARGILL, Catherine E, BLANCHARD, Andrew P, SHARMA, Raman, DANDENEAU, Andre A, GOODWIN, Joseph J, TURNER, Stephanie D, ERVE, John C. L

“…Azamulin [14- O -(5-(2-amino-1,3,4-triazolyl)thioacetyl)-dihydromutilin] is an azole derivative of the pleuromutilin class of antiinfectives. We tested the…”
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Cytochrome P450 Fluorometric Substrates: Identification of Isoform-Selective Probes for Rat CYP2D2 and Human CYP3A4 by STRESSER, David M, TURNER, Stephanie D, BLANCHARD, Andrew P, MILLER, Vaughn P, CRESPI, Charles L

“…We have tested a panel of 29 cDNA-expressed rat and human enzymes with 9 fluorometric substrates to determine the P450 isoform selectivity in the catalysis of…”
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HUMAN CYTOCHROME P450 INDUCTION AND INHIBITION POTENTIAL OF CLEVIDIPINE AND ITS PRIMARY METABOLITE H152/81 by ZHANG, J. George, DEHAL, Shangara S, HO, Thuy, JOHNSON, Jennifer, CHANDLER, Catherine, BLANCHARD, Andrew P, CLARK, Robert J, CRESPI, Charles L, STRESSER, David M, WONG, James

“…Clevidipine is a short-acting dihydropyridine calcium channel antagonist under development for treatment of perioperative hypertension. Patients treated with…”
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Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole by Stresser, David M, Perloff, Elke S, Mason, Andrew K, Blanchard, Andrew P, Dehal, Shangara S, Creegan, Timothy P, Singh, Ritu, Gangl, Eric T

“…The sedative clomethiazole (CMZ) has been used in Europe since the mid-1960s to treat insomnia and alcoholism. It has been previously demonstrated in clinical…”
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Fluorometric High-Throughput Screening for Inhibitors of Cytochrome P450 by MILLER, VAUGHN P., STRESSER, DAVID M., BLANCHARD, ANDREW P., TURNER, STEPHANIE, CRESPI, CHARLES L.

“…: Rapid screening for cytochrome P450 inhibitors is part of the current paradigm for avoiding development of drugs likely to give clinical pharmacokinetic…”
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Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible by Stresser, David M, Broudy, Marc I, Ho, Thuy, Cargill, Catherine E, Blanchard, Andrew P, Sharma, Raman, Dandeneau, Andre A, Goodwin, Joseph J, Turner, Stephanie D, Erve, John C L, Patten, Christopher J, Dehal, Shangara S, Crespi, Charles L

“…Azamulin [14-O-(5-(2-amino-1,3,4-triazolyl)thioacetyl)-dihydromutilin] is an azole derivative of the pleuromutilin class of antiinfectives. We tested the…”
Get full text