Search Results - "Blanchard, Andrew"

Automating Genetic Algorithm Mutations for Molecules Using a Masked Language Model by Blanchard, Andrew E., Shekar, Mayanka Chandra, Gao, Shang, Gounley, John, Lyngaas, Isaac, Glaser, Jens, Bhowmik, Debsindhu

“…Inspired by the evolution of biological systems, genetic algorithms have been applied to generate solutions for optimization problems in a variety of…”
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Circuit-Host Coupling Induces Multifaceted Behavioral Modulations of a Gene Switch by Blanchard, Andrew E., Liao, Chen, Lu, Ting

“…Quantitative modeling of gene circuits is fundamentally important to synthetic biology, as it offers the potential to transform circuit engineering from…”
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Bacterial social interactions drive the emergence of differential spatial colony structures by Blanchard, Andrew E, Lu, Ting

“…Social interactions have been increasingly recognized as one of the major factors that contribute to the dynamics and function of bacterial communities. To…”
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Engineering robust and tunable spatial structures with synthetic gene circuits by Kong, Wentao, Blanchard, Andrew E, Liao, Chen, Lu, Ting

“…Controllable spatial patterning is a major goal for the engineering of biological systems. Recently, synthetic gene circuits have become promising tools to…”
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An integrative circuit–host modelling framework for predicting synthetic gene network behaviours by Liao, Chen, Blanchard, Andrew E., Lu, Ting

“…One fundamental challenge in synthetic biology is the lack of quantitative tools that accurately describe and predict the behaviours of engineered gene…”
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Repulsive expansion dynamics in colony growth and gene expression by Cao, Yangxiaolu, Neu, John, Blanchard, Andrew E, Lu, Ting, You, Lingchong

“…Spatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional…”
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Using GANs with adaptive training data to search for new molecules by Blanchard, Andrew E., Stanley, Christopher, Bhowmik, Debsindhu

“…The process of drug discovery involves a search over the space of all possible chemical compounds. Generative Adversarial Networks (GANs) provide a valuable…”
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Host-Microbial Interactions in Idiopathic Pulmonary Fibrosis by Molyneaux, Philip L, Willis-Owen, Saffron A G, Cox, Michael J, James, Phillip, Cowman, Steven, Loebinger, Michael, Blanchard, Andrew, Edwards, Lindsay M, Stock, Carmel, Daccord, Cécile, Renzoni, Elisabetta A, Wells, Athol U, Moffatt, Miriam F, Cookson, William O C, Maher, Toby M

“…Changes in the respiratory microbiome are associated with disease progression in idiopathic pulmonary fibrosis (IPF). The role of the host response to the…”
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A Highly Tilted Membrane Configuration for the Prefusion State of Synaptobrevin by Blanchard, Andrew E., Arcario, Mark J., Schulten, Klaus, Tajkhorshid, Emad

“…The SNARE complex plays a vital role in vesicle fusion arising during neuronal exocytosis. Key components in the regulation of SNARE complex formation, and…”
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Development of message passing-based graph convolutional networks for classifying cancer pathology reports by Yoon, Hong-Jun, Klasky, Hilda B, Blanchard, Andrew E, Christian, J Blair, Durbin, Eric B, Wu, Xiao-Cheng, Stroup, Antoinette, Doherty, Jennifer, Coyle, Linda, Penberthy, Lynne, Tourassi, Georgia D

“…Applying graph convolutional networks (GCN) to the classification of free-form natural language texts leveraged by graph-of-words features (TextGCN) was…”
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Language models for the prediction of SARS-CoV-2 inhibitors by Blanchard, Andrew E, Gounley, John, Bhowmik, Debsindhu, Chandra Shekar, Mayanka, Lyngaas, Isaac, Gao, Shang, Yin, Junqi, Tsaris, Aristeidis, Wang, Feiyi, Glaser, Jens

“…The COVID-19 pandemic highlights the need for computational tools to automate and accelerate drug design for novel protein targets. We leverage deep learning…”
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Adaptive language model training for molecular design by Blanchard, Andrew E., Bhowmik, Debsindhu, Fox, Zachary, Gounley, John, Glaser, Jens, Akpa, Belinda S., Irle, Stephan

“…The vast size of chemical space necessitates computational approaches to automate and accelerate the design of molecular sequences to guide experimental…”
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An Ecological Understanding of Quorum Sensing-Controlled Bacteriocin Synthesis by Blanchard, Andrew E., Liao, Chen, Lu, Ting

“…Bacteriocins are common antimicrobial agents that bacteria secrete to suppress the growth of competitors. Their production is often conditional, governed by…”
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Scalable training of graph convolutional neural networks for fast and accurate predictions of HOMO-LUMO gap in molecules by Choi, Jong Youl, Zhang, Pei, Mehta, Kshitij, Blanchard, Andrew, Lupo Pasini, Massimiliano

“…Graph Convolutional Neural Network (GCNN) is a popular class of deep learning (DL) models in material science to predict material properties from the graph…”
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A Keyword-Enhanced Approach to Handle Class Imbalance in Clinical Text Classification by Blanchard, Andrew E., Gao, Shang, Yoon, Hong-Jun, Christian, J. Blair, Durbin, Eric B., Wu, Xiao-Cheng, Stroup, Antoinette, Doherty, Jennifer, Schwartz, Stephen M., Wiggins, Charles, Coyle, Linda, Penberthy, Lynne, Tourassi, Georgia D.

“…Recent applications ofdeep learning have shown promising results for classifying unstructured text in the healthcare domain. However, the reliability of models…”
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Extinction, coexistence, and localized patterns of a bacterial population with contact-dependent inhibition by Blanchard, Andrew E, Celik, Venhar, Lu, Ting

“…Contact-dependent inhibition (CDI) has been recently revealed as an intriguing but ubiquitous mechanism for bacterial competition in which a species injects…”
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Spatial interference scale as a determinant of microbial range expansion by Celik Ozgen, Venhar, Kong, Wentao, Blanchard, Andrew E, Liu, Feng, Lu, Ting

“…In microbial communities, social interactions such as competition occur ubiquitously across multiple spatial scales from local proximity to remote distance…”
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Slow and Steady Wins the Race: A Bacterial Exploitative Competition Strategy in Fluctuating Environments by Mao, Junwen, Blanchard, Andrew E, Lu, Ting

“…One promising frontier for synthetic biology is the development of synthetic ecologies, whereby interacting species form an additional layer of connectivity…”
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Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole by Stresser, David M, Perloff, Elke S, Mason, Andrew K, Blanchard, Andrew P, Dehal, Shangara S, Creegan, Timothy P, Singh, Ritu, Gangl, Eric T

“…The sedative clomethiazole (CMZ) has been used in Europe since the mid-1960s to treat insomnia and alcoholism. It has been previously demonstrated in clinical…”
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180-GHz Broadside Radiation Bond-Wire Antenna for Short-Range Wireless Communication by Bakshi, Harshpreet S., Dong, Shenggang, Momson, Ibukunoluwa, Chacon, Diego, Chen, Zhe, Choi, Wooyeol, Blanchard, Andrew J., O, Kenneth K.

“…A technique for realizing an efficient broadside radiation bond-wire antenna for short-range wireless communication is demonstrated. The bond wire forming the…”
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