Search Results - "Blanc, K"

Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy by Krampera, Mauro, Le Blanc, Katarina

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Multipotent mesenchymal stromal cells and the innate immune system by Le Blanc, Katarina, Mougiakakos, Dimitrios

“…Key Points Multipotent mesenchymal stromal cells (MSCs) are multipotent cells that were initially isolated from the bone marrow. They have been identified in…”
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Immunomodulation by mesenchymal stem cells and clinical experience by Le Blanc, K., Ringdén, O.

“…Mesenchymal stem cells (MSCs) from adult marrow can differentiate in vitro and in vivo into various cell types, such as bone, fat and cartilage. MSCs…”
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Analysis of Tissues Following Mesenchymal Stromal Cell Therapy in Humans Indicates Limited Long-Term Engraftment and No Ectopic Tissue Formation by von Bahr, L., Batsis, I., Moll, G., Hägg, M., Szakos, A., Sundberg, B., Uzunel, M., Ringden, O., Le Blanc, K.

“…Mesenchymal stromal cells (MSCs) are explored as a novel treatment for a variety of medical conditions. Their fate after infusion is unclear, and long‐term…”
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Mesenchymal stromal cells and the innate immune response by Le Blanc, Katarina, Davies, Lindsay C

“…Highlights • MSC interactions with innate immune cells. • MSCs exert both pro- and anti-inflammatory effects. • MSCs are immunomodulatory through cell–cell…”
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Mesenchymal Stromal Cell Secretion of Programmed Death‐1 Ligands Regulates T Cell Mediated Immunosuppression by Davies, Lindsay C., Heldring, Nina, Kadri, Nadir, Le Blanc, Katarina

“…Mesenchymal stromal cells (MSCs) exert broad immunosuppressive potential, modulating the activity of cells of innate and adaptive immune systems. As MSCs…”
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Challenges for mesenchymal stromal cell therapies by Martin, Ivan, Galipeau, Jacques, Kessler, Charles, Le Blanc, Katarina, Dazzi, Francesco

“…Clinical trials of mesenchymal stromal cell therapies reveal a challenging heterogeneous landscape, including diverse therapeutic targets, patient categories,…”
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Immunomodulatory effects of fetal and adult mesenchymal stem cells by Le Blanc, K.

“…Mesenchymal stem cells (MSC) derived from adult BM or fetal liver form several mesenchymal tissues after appropriate stimulation. Reports indicate that MSC…”
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Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells by Carlsson, Per-Ola, Schwarcz, Erik, Korsgren, Olle, Le Blanc, Katarina

“…The retention of endogenous insulin secretion in type 1 diabetes is an attractive clinical goal, which opens possibilities for long-term restoration of glucose…”
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MSCs—cells with many sides by Le Blanc, Katarina, Davies, Lindsay C

“…Abstract The field of mesenchymal stromal cell (MSC) biology and clinical cellular therapy has grown exponentially over the last few decades. With discovery of…”
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Mesenchymal stromal cells: tissue repair and immune modulation by Le Blanc, K.

“…BM-derived mesenchymal stromal cells (MSC) differentiate along the mesenchymal lineage to bone, fat and cartilage. In vitro, MSC induce little, if any,…”
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Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells by LE BLANC, K, SAMUELSSON, H, GUSTAFSSON, B, REMBERGER, M, SUNDBERG, B, ARVIDSON, J, LJUNGMAN, P, LÖNNIES, H, NAVA, S, RINGDEN, O

“…Seven patients underwent treatment with mesenchymal stem cells (MSCs), together with allogeneic hematopoietic stem cell transplantation (HSCT). MSCs were given…”
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Concise Review: Hitting the Right Spot with Mesenchymal Stromal Cells by Tolar, Jakub, Le Blanc, Katarina, Keating, Armand, Blazar, Bruce R.

“…Mesenchymal stromal cells or mesenchymal stem cells (MSCs) have captured considerable scientific and public interest because of their potential to limit…”
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New findings for maternal mortality age patterns: aggregated results for 38 countries by Blanc, Ann K, Winfrey, William, Ross, John

“…With recent results showing a global decline in overall maternal mortality during the last two decades and with the target date for achieving the Millennium…”
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement by Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F.C, Krause, D.S., Deans, R.J., Keating, A., Prockop, D.J., Horwitz, E.M.

“…The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of…”
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Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex by Le Blanc, K., Tammik, L., Sundberg, B., Haynesworth, S. E., Ringdén, O.

“…We aimed to study the effects of mesenchymal stem cells (MSCs) on alloreactivity and effects of T‐cell activation on human peripheral blood lymphocytes (PBLs)…”
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Targeting Suppressive Myeloid Cells Potentiates Checkpoint Inhibitors to Control Spontaneous Neuroblastoma by Mao, Yumeng, Eissler, Nina, Blanc, Katarina Le, Johnsen, John Inge, Kogner, Per, Kiessling, Rolf

“…Neuroblastoma is the most common extracranial solid cancer type in childhood, and high-risk patients have poor prognosis despite aggressive multimodal…”
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Mesenchymal Stem Cells Stimulate Antibody Secretion in Human B Cells by Rasmusson, I, Le Blanc, K, Sundberg, B, Ringdén, O

“…Mesenchymal stem cells (MSC) have immunomodulatory effects and inhibit T-cell responses to alloantigens and mitogens in vitro and in vivo. We wanted to examine…”
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Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein by Qian, Hong, Le Blanc, Katarina, Sigvardsson, Mikael

“…Background: The natural phenotype of mesenchymal stem cells (MSCs) has not been well characterized. Results: MSCs from bone marrow naturally are CD44−;…”
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Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles by Heldring, Nina, Mäger, Imre, Wood, Matthew J A, Le Blanc, Katarina, Andaloussi, Samir E L

“…The therapeutic potential of mesenchymal stromal cells (MSCs) is evident by the number of new and ongoing trials targeting an impressive variety of conditions…”
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