Management of febrile urinary tract infection among spinal cord injured patients

Urinary tract infection (UTI) among patients with neurogenic bladder is a major problem but its management is not well known. We studied the relationship between antibiotic regimen use and the cure rate of those infections among 112 patients with neurogenic bladder. We studied a retrospective cohort...

Full description

Saved in:

Bibliographic Details
Published in:	BMC infectious diseases Vol. 16; no. 153; p. 156
Main Authors:	Dinh, Aurélien, Toumi, Adnène, Blanc, Constance, Descatha, Alexis, Bouchand, Frédérique, Salomon, Jérôme, Hanslik, Thomas, Bernuz, Benjamin, Denys, Pierre, Bernard, Louis
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 16-04-2016 BioMed Central
Subjects:	Adult Anti-Bacterial Agents - therapeutic use Antibiotics Care and treatment Cohort Studies Complications and side effects Drug Therapy, Combination Enterococcus - isolation & purification Escherichia coli - isolation & purification Female Health aspects Humans Infectious diseases Intensive Care Units Male Middle Aged Pseudomonas aeruginosa - isolation & purification Retrospective Studies Risk factors Spinal cord injuries Spinal Cord Injuries - complications Spinal Cord Injuries - diagnosis Urinary Bladder, Neurogenic - complications Urinary tract infections Urinary Tract Infections - complications Urinary Tract Infections - drug therapy Urinary Tract Infections - microbiology Urinary tract infection Neurogenic bladder Antibiotic treatment duration
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Urinary tract infection (UTI) among patients with neurogenic bladder is a major problem but its management is not well known. We studied the relationship between antibiotic regimen use and the cure rate of those infections among 112 patients with neurogenic bladder. We studied a retrospective cohort of febrile UTI among patients with neurogenic bladder. Drug selection was left to the discretion of the treating physicians, in accordance with current guidelines. Patients were divided into 3 groups according to antibiotic treatment duration (<10 days, between 10 and 15 days, and >15 days). We analysed clinical and microbiogical cure rate one month after the end of antibiotic treatment. The three groups of patients were similar, especially in terms of drug treatment (equal distribution). The cure rates were not significantly different (71.4 %, 54.2 %, and 57.1 %, respectively; p = 0.34). Moreover, there was no difference in cure rate between mono and dual therapy (44 % for monotherapy vs. 40 % for dual therapy; p = 0.71). This descriptive study supports the efficacy of antimicrobial treatment duration of less than 10 days and the use of monotherapy to treat febrile UTI among patients with neurogenic bladder. A randomized control trial is required to confirm these data.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-016-1484-4