Search Results - "Blanc, C. Le"
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Quantitative structural multiclass lipidomics using differential mobility: electron impact excitation of ions from organics (EIEIO) mass spectrometry
Published in Journal of lipid research (2018)“…We report a method for comprehensive structural characterization of lipids in animal tissues using a combination of differential ion mobility spectrometry…”
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Protonation‐Induced Chirality Drives Separation by Differential Ion Mobility Spectrometry
Published in Angewandte Chemie International Edition (21-02-2022)“…Upon development of a workflow to analyze (±)‐Verapamil and its metabolites using differential mobility spectrometry (DMS), we noticed that the ionogram of…”
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Structural identification of triacylglycerol isomers using electron impact excitation of ions from organics (EIEIO)[S]
Published in Journal of lipid research (01-11-2016)“…Electron-induced dissociation or electron impact excitation of ions from organics (EIEIO) was applied to triacylglycerols (TAGs) for in-depth molecular…”
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Transient Incomplete Separation Facilitates Finding Accurate Equilibrium Dissociation Constant of Protein–Small Molecule Complex
Published in Angewandte Chemie International Edition (13-05-2019)“…Current practical methods for finding the equilibrium dissociation constant, Kd, of protein–small molecule complexes have inherent sources of inaccuracy…”
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Determining molecular properties with differential mobility spectrometry and machine learning
Published in Nature communications (30-11-2018)“…The fast and accurate determination of molecular properties is highly desirable for many facets of chemical research, particularly in drug discovery where…”
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The Apollon 10 PW laser: experimental and theoretical investigation of the temporal characteristics
Published in High power laser science and engineering (2016)“…The objective of the Apollon 10 PW project is the generation of 10 PW peak power pulses of 15 fs at $1~\text{shot}~\text{min}^{-1}$. In this paper a brief…”
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Design and current progress of the Apollon 10 PW project
Published in High power laser science and engineering (2015)“…The objective of the Apollon project is the generation of 10 PW peak power pulses of 15 fs at 1 shot/minute. In this paper the Apollon facility design, the…”
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Probing Electrospray Ionization Dynamics Using Differential Mobility Spectrometry: The Curious Case of 4‑Aminobenzoic Acid
Published in Analytical chemistry (Washington) (18-09-2012)“…Here, we present the separation of two ions that differ only by the site of protonation of the analyte molecule using differential mobility spectrometry (DMS)…”
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Medical check-up of newly arrived unaccompanied minors: A dedicated pediatric consultation service in a hospital
Published in Archives de pédiatrie : organe officiel de la Société française de pédiatrie (01-11-2021)“…Healthcare for the increasing number of migrants in Europe, and particularly of unaccompanied minors (UMs) seeking asylum, has become a major challenge. We…”
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Streamlined Development of Targeted Mass Spectrometry‐Based Method Combining Scout‐MRM and a Web‐Based Tool Indexed with Scout Peptides
Published in Proteomics (Weinheim) (01-01-2020)“…MS‐based targeted proteomics is a relevant technology for sensitive and robust relative or absolute quantification of proteins biomarker candidates in complex…”
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Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
Published in ACS central science (22-02-2017)“…The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the…”
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Distinguishing Cis and Trans Isomers in Intact Complex Lipids Using Electron Impact Excitation of Ions from Organics Mass Spectrometry
Published in Analytical chemistry (Washington) (18-07-2017)“…We present a mass spectrometry-based method for the identification of cis and trans double-bond isomers within intact complex lipid mixtures using electron…”
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Open Port Interface for Coupling Capillary Electrophoresis and Mass Spectrometry: Performance Evaluation for Capillary Isoelectric Focusing
Published in Journal of the American Society for Mass Spectrometry (04-10-2023)“…Capillary electrophoresis (CE) combined with mass spectrometry (MS) is a powerful analytical technique that utilizes the resolving power of CE and the…”
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Analyzing Glycopeptide Isomers by Combining Differential Mobility Spectrometry with Electron- and Collision-Based Tandem Mass Spectrometry
Published in Journal of the American Society for Mass Spectrometry (01-07-2017)“…Differential mobility spectrometry (DMS) has been employed to separate isomeric species in several studies. Under the right conditions, factors such as…”
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In-depth sphingomyelin characterization using electron impact excitation of ions from organics and mass spectrometry[S]
Published in Journal of lipid research (01-05-2016)“…Electron impact excitation of ions from organics (EIEIO), also referred to as electron-induced dissociation, was applied to singly charged SM molecular species…”
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Hyperspectral Visualization-Based Mass Spectrometry Imaging by LMJ-SSP: A Novel Strategy for Rapid Natural Product Profiling in Bacteria
Published in Analytical chemistry (Washington) (24-01-2023)“…Mass spectrometry imaging (MSI) has been widely used to discover natural products (NPs) from underexplored microbiological sources. However, the technique is…”
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Transient Incomplete Separation of Species with Close Diffusivity to Study the Stability of Affinity Complexes
Published in Analytical chemistry (Washington) (08-11-2022)“…Large molecules can be generically separated from small ones, though partially and temporarily, in a pressure-driven flow inside a capillary. This transient…”
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Enhancing signal and mitigating up-front peptide fragmentation using controlled clustering by gas-phase modifiers
Published in Analytical and bioanalytical chemistry (01-09-2019)“…Up-front CID fragmentation is a phenomenon where molecular ions are activated and fragment as they enter the atmosphere-to-vacuum region of the mass…”
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Electron Capture Dissociation in a Branched Radio-Frequency Ion Trap
Published in Analytical chemistry (Washington) (06-01-2015)“…We have developed a high-throughput electron capture dissociation (ECD) device coupled to a quadrupole time-of-flight mass spectrometer using novel branched…”
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Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface
Published in Analytica chimica acta (23-10-2017)“…Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed…”
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