Search Results - "Blanar, Michael A."

Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3) by Lee, Ning, Chen, Jian, Sun, Lucy, Wu, Shujian, Gray, Kevin R., Rich, Adam, Huang, Minxue, Lin, Jun-Hsiang, Feder, John N., Janovitz, Evan B., Levesque, Paul C., Blanar, Michael A.

“…Transient receptor potential (TRP) cation-selective channels are an emerging class of proteins that are involved in a variety of important biological functions…”
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The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins by Madsen, Cort S, Janovitz, Evan, Zhang, Rongan, Nguyen-Tran, Van, Ryan, Carol S, Yin, Xiaohong, Monshizadegan, Hossain, Chang, Ming, D'Arienzo, Celia, Scheer, Susan, Setters, Robert, Search, Debra, Chen, Xing, Zhuang, Shaobin, Kunselman, Lori, Peters, Andrew, Harrity, Thomas, Apedo, Atsu, Huang, Christine, Cuff, Carolyn A, Kowala, Mark C, Blanar, Michael A, Sun, Chong-Qing, Robl, Jeffrey A, Stein, Philip D

“…Statins, because of their excellent efficacy and manageable safety profile, represent a key component in the current armamentarium for the treatment of…”
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Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453) by Li, Jun, Kennedy, Lawrence J, Shi, Yan, Tao, Shiwei, Ye, Xiang-Yang, Chen, Stephanie Y, Wang, Ying, Hernández, Andrés S, Wang, Wei, Devasthale, Pratik V, Chen, Sean, Lai, Zhi, Zhang, Hao, Wu, Shung, Smirk, Rebecca A, Bolton, Scott A, Ryono, Denis E, Zhang, Huiping, Lim, Ngiap-Kie, Chen, Bang-Chi, Locke, Kenneth T, O’Malley, Kevin M, Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S, Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K, Cap, Michael, Kadiyala, Pathanjali, Hosagrahara, Vinayak, Zhang, Lisa, Xu, Carrie, Li, Yi-Xin, Muckelbauer, Jodi K, Chang, Chiehying, An, Yongmi, Krystek, Stanley R, Blanar, Michael A, Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T. W, Tino, Joseph A

“…An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist,…”
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(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential by Ahmad, Saleem, Madsen, Cort S, Stein, Philip D, Janovitz, Evan, Huang, Christine, Ngu, Khehyong, Bisaha, Sharon, Kennedy, Lawrence J, Chen, Bang-Chi, Zhao, Rulin, Sitkoff, Doree, Monshizadegan, Hossain, Yin, Xiaohong, Ryan, Carol S, Zhang, Rongan, Giancarli, Mary, Bird, Eileen, Chang, Ming, Chen, Xing, Setters, Robert, Search, Debra, Zhuang, Shaobin, Nguyen-Tran, Van, Cuff, Carolyn A, Harrity, Thomas, Darienzo, Celia J, Li, Tong, Reeves, Richard A, Blanar, Michael A, Barrish, Joel C, Zahler, Robert, Robl, Jeffrey A

“…3-Hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating…”
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Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist by Shi, Yan, Li, Jun, Kennedy, Lawrence J, Tao, Shiwei, Hernández, Andrés S, Lai, Zhi, Chen, Sean, Wong, Henry, Zhu, Juliang, Trehan, Ashok, Lim, Ngiap-Kie, Zhang, Huiping, Chen, Bang-Chi, Locke, Kenneth T, O’Malley, Kevin M, Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S, Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K, Cap, Michael, Muckelbauer, Jodi, Chang, Chiehying, Krystek, Stanley R, Li, Yi-Xin, Hosagrahara, Vinayak, Zhang, Lisa, Kadiyala, Pathanjali, Xu, Carrie, Blanar, Michael A, Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T. W, Tino, Joseph A

“…BMS-711939 (3) is a potent and selective peroxisome proliferator-activated receptor (PPAR) α agonist, with an EC50 of 4 nM for human PPARα and >1000-fold…”
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Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt by Kontos, Christopher D., Stauffer, Thomas P., Yang, Wen-Pin, York, John D., Huang, Liwen, Blanar, Michael A., Meyer, Tobias, Peters, Kevin G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Functional Expression of Two KvLQT1-related Potassium Channels Responsible for an Inherited Idiopathic Epilepsy by Yang, Wen-Pin, Levesque, Paul C., Little, Wayne A., Conder, Mary Lee, Ramakrishnan, Pankajavalli, Neubauer, Michael G., Blanar, Michael A.

“…Benign familial neonatal convulsions (BFNC), a class of idiopathic generalized epilepsy, is an autosomal dominantly inherited disorder of newborns. BFNC has…”
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KvLQT1, a Voltage-Gated Potassium Channel Responsible for Human Cardiac Arrhythmias by Yang, Wen-Pin, Levesque, Paul C., Little, Wayne A., Conder, Mary Lee, Shalaby, Fouad Y., Blanar, Michael A.

“…The clinical features of long QT syndrome result from episodic life-threatening cardiac arrhythmias, specifically the polymorphic ventricular tachycardia…”
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Interaction Cloning: Identification of a Helix-Loop-Helix Zipper Protein That Interacts With c-Fos by Blanar, Michael A., Rutter, William J.

“…A facile method for isolating genes that encode interacting proteins has been developed with a polypeptide probe that contains an amino-terminal extension with…”
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Dominant-negative KvLQT1 Mutations underlie the LQT1 form of long QT syndrome by SHALABY, F. Y, LEVESQUE, P. C, YANG, W.-P, LITTLE, W. A, CONDER, M. L, JENKINS-WEST, T, BLANAR, M. A

“…Mutations that map to the KvLQT1 gene on human chromosome 11 account for more than 50% of inherited long QT syndrome (LQTS). It has been discovered recently…”
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HCPTPA, a Protein Tyrosine Phosphatase That Regulates Vascular Endothelial Growth Factor Receptor-mediated Signal Transduction and Biological Activity by Huang, L, Sankar, S, Lin, C, Kontos, C D, Schroff, A D, Cha, E H, Feng, S M, Li, S F, Yu, Z, Van Etten, R L, Blanar, M A, Peters, K G

“…Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to…”
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Aortic Carboxypeptidase-like Protein, a Novel Protein with Discoidin and Carboxypeptidase-like Domains, Is Up-regulated during Vascular Smooth Muscle Cell Differentiation by Layne, M D, Endege, W O, Jain, M K, Yet, S F, Hsieh, C M, Chin, M T, Perrella, M A, Blanar, M A, Haber, E, Lee, M E

“…Phenotypic modulation of vascular smooth muscle cells plays an important role in the pathogenesis of arteriosclerosis. In a screen of proteins expressed in…”
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Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel by Erginel-Unaltuna, Nihan, Yang, Wen-Pin, Blanar, Michael A

“…ATP-sensitive K + (K ATP) channels are implicated in the coupling of metabolic energy to membrane potential, thereby regulating many essential cell functions…”
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Cloning and Characterization of a Basic Helix-Loop-Helix Protein Expressed in Early Mesoderm and the Developing Somites by Quertermous, Elena E., Hidai, Hiroko, Blanar, Michael A., Quertermous, Thomas

“…Basic helix-loop-helix (bHLH) heterodimer protein complexes regulate transcription of genes during the processes of differentiation and development. To study…”
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Meso1, a Basic-Helix-Loop-Helix Protein Involved in Mammalian Presomitic Mesoderm Development by Blanar, Michael A., Crossley, Philip H., Peters, Kevin G., Steingrimsson, Eirikur, Copeland, Neal G., Jenkins, Nancy A., Martin, Gail R., Rutter, William J.

“…To identify genes involved in the regulation of early mammalian development, we have developed a dominant-negative mutant basic-helix-loop-helix (bHLH) protein…”
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Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development by Cross, J C, Flannery, M L, Blanar, M A, Steingrimsson, E, Jenkins, N A, Copeland, N G, Rutter, W J, Werb, Z

“…Trophoblast cells are the first lineage to form in the mammalian conceptus and mediate the process of implantation. We report the cloning of a basic…”
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Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties by Kaelin, Jr, W G, Krek, W, Sellers, W R, DeCaprio, J A, Ajchenbaum, F, Fuchs, C S, Chittenden, T, Li, Y, Farnham, P J, Blanar, M A

“…An expression vector was modified to permit the rapid synthesis of purified, 32P-labeled, glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins…”
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Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor [alpha] Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453) by Li, Jun, Kennedy, Lawrence J., Shi, Yan, Tao, Shiwei, Ye, Xiang-Yang, Chen, Stephanie Y., Wang, Ying, Hernndez, Andrs S., Wang, Wei, Devasthale, Pratik V., Chen, Sean, Lai, Zhi, Zhang, Hao, Wu, Shung, Smirk, Rebecca A., Bolton, Scott A., Ryono, Denis E., Zhang, Huiping, Lim, Ngiap-Kie, Chen, Bang-Chi, Locke, Kenneth T., O’Malley, Kevin M., Zhang, Litao, Srivastava, Rai Ajit, Miao, Bowman, Meyers, Daniel S., Monshizadegan, Hossain, Search, Debra, Grimm, Denise, Zhang, Rongan, Harrity, Thomas, Kunselman, Lori K., Cap, Michael, Kadiyala, Pathanjali, Hosagrahara, Vinayak, Zhang, Lisa, Xu, Carrie, Li, Yi-Xin, Muckelbauer, Jodi K., Chang, Chiehying, An, Yongmi, Krystek, Stanley R., Blanar, Michael A., Zahler, Robert, Mukherjee, Ranjan, Cheng, Peter T.W., Tino, Joseph A.

“…An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) {alpha}…”
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The p50 Subunit of NF-κB Associates with the NF-IL6 Transcription Factor by LeClair, Kenneth P., Blanar, Michael A., Sharp, Phillip A.

“…The NF-κB-p50 polypeptide, a member of the Rel family of transcription factors, was produced as a fusion protein containing amino-terminal peptide additions…”
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(3R,5S,E)-7-4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyri-midin-5-yl-3,5-dihydroxyhept-6-enoic Acid (BMS-644950) : A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential by AHMAD, Saleem, MADSEN, Cort S, SITKOFF, Doree, MONSHIZADEGAN, Hossain, XIAOHONG YIN, RYAN, Carol S, RONGAN ZHANG, GIANCARLI, Mary, BIRD, Eileen, MING CHANG, XING CHEN, SETTERS, Robert, STEIN, Philip D, SEARCH, Debra, SHAOBIN ZHUANG, NGUYEN-TRAN, Van, CUFF, Carolyn A, HARRITY, Thomas, DARIENZO, Celia J, TONG LI, REEVES, Richard A, BLANAR, Michael A, BARRISH, Joel C, JANOVITZ, Evan, ZAHLER, Robert, ROBI, Jeffrey A, HUANG, Christine, NGU, Khehyong, BISAHA, Sharon, KENNEDY, Lawrence J, CHEN, Bang-Chi, RULIN ZHAO

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