Search Results - "Blakey, G. E."

Pharmacokinetic and pharmacodynamic assessment of a five‐probe metabolic cocktail for CYPs 1A2, 3A4, 2C9, 2D6 and 2E1 by Blakey, G. E., Lockton, J. A., Perrett, J., Norwood, P., Russell, M., Aherne, Z., Plume, J.

“…Aims  The primary objectives of the present study were to establish whether there was a pharmacokinetic or pharmacodynamic interaction between the probe drugs…”
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Evaluation of a pharmacokinetic interaction between remacemide hydrochloride and phenobarbitone in healthy males by Hooper, W. D., Eadie, M. J., Blakey, G. E., Lockton, J. A., Manun'Ebo, M.

“…Aims  To determine whether there is a pharmacokinetic interaction between the antiepileptic drugs remacemide and phenobarbitone. Methods  In a group of 12…”
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Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat by Blakey, G E, Nestorov, I A, Arundel, P A, Aarons, L J, Rowland, M

“…As part of an overall program to develop a framework for evaluating the contribution of structural and physicochemical properties to pharmacokinetics, the…”
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Development of an assay for the extraction and quantification of nine 5- n-alkyl-5-ethyl barbituric acids in various rat tissues by Blakey, G.E, Ballard, P, Leahy, D.E, Rowland, M

“…Methods were developed to quantify a series of nine homologous 5- n-alkyl-5-ethyl barbituric acids in 15 rat tissues. Tissue homogenates were spiked with one…”
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Safety, tolerability, and pharmacokinetics of remacemide in children by Besag, Frank M.C., Newton, Rosemary E., Blakey, Graham E., Dean, Andrew D.P.

“…Eleven patients (nine males, two females), 9–14 years of age, received adjunctive therapy with remacemide in an open ascending-dose study at two residential…”
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Quantitative Structure-Pharmacokinetics Relationships: I. Development of Whole-Body Physiologically Based Model to Characterize Changes in Pharmacokinetics Across a Homologous Series of Barbiturates in the Rat by Blakey, Graham E, Nestorov, Ivan A, Arundel, Philip A, Aarons, Leon J, Rowland, Malcolm

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