Search Results - "Blaker, Paul A"

Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration by Kapoor, Raju, Davies, Meirion, Blaker, Paul A., Hall, Susan M., Smith, Kenneth J.

“…Axonal degeneration can be an important cause of permanent disability in neurological disorders in which inflammation is prominent, including multiple…”
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Thiopurines Dosed to a Therapeutic 6-Thioguanine Level in Combination with Adalimumab Are More Effective Than Subtherapeutic Thiopurine-based Combination Therapy or Adalimumab Monotherapy During Induction and Maintenance in Patients with Long-standing Crohn's Disease by Kariyawasam, Viraj C, Ward, Mark G, Blaker, Paul A, Patel, Kamal V, Goel, Rishi, Sanderson, Jeremy D, Irving, Peter M

“…The benefit of concomitant immunomodulation with adalimumab (ADA) in Crohn's disease is poorly understood. We aimed to compare ADA monotherapy with combination…”
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Management of acute severe ulcerative colitis (NICE CG 166) by Macken, Lucia, Blaker, Paul A

“…Ulcerative colitis (UC) presents as an acute severe flare in 10–15% of new cases and it occurs in 15% of patients with established disease. Acute severe UC can…”
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Is there a role for thioguanine therapy in IBD in 2017 and beyond? by Taylor, Kirstin M, Ward, Mark G, Blaker, Paul A, Sparrow, Miles P

“…Conventional thiopurines are effective for the maintenance of remission of Crohn's disease and ulcerative colitis, however, up to half of patients are…”
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Abdominal hereditary angio-oedema caught on magnetic resonance imaging by Siow, Mayven Tien Li, Robertson, Alexander Myles, Ghurye, Rohit R, Blaker, Paul A

“…A 17-year-old woman presented with a 3-year history of recurrent, severe abdominal pain with spontaneous resolution within a few days. An ultrasound revealed…”
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Thioguanine in inflammatory bowel disease: Long-term efficacy and safety by Ward, Mark G, Patel, Kamal V, Kariyawasam, Viraj C, Goel, Rishi, Warner, Ben, Elliott, Tim R, Blaker, Paul A, Irving, Peter M, Marinaki, Anthony M, Sanderson, Jeremy D

“…Background Thioguanine (TG) is efficacious in inflammatory bowel disease (IBD), but its toxicity, particularly nodular regenerative hyperplasia (NRH) of the…”
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343 Azathioprine Decreases the Risk of Adalimumab Primary Non-Response and Secondary Loss of Response but Only if Adequately Dosed by Kariyawasam, Viraj C, Ward, Mark G, Blaker, Paul A, Anderson, Simon H, Sanderson, Jeremy D, Irving, Peter M

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Tu1925 Novel Pathway-Centric Analysis Reveals Variants Associated With Toxicity and Response to Thiopurines in Patients With Inflammatory Bowel Disease by Blaker, Paul A, Fong, Steven C, Walker, Jemma, Lewis, Cathryn, Corrigan, Adele, Irving, Peter M, Marinaki, Anthony M, Sanderso, Jeremy D

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Sa1262 The Impact of Thiopurine Hypermethylation on Clinical Outcomes in Patients With Inflammatory Bowel Disease by Blaker, Paul A, Fong, Steven C, Smith, Melissa A, Kariyawasam, Viraj C, Marinaki, Anthony M, Irving, Peter M, van Sanderso, Jeremy D

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Sa1911 Calculating the “Missed Opportunity” of Thiopurine Monotherapy Overcome With Thiopurine and Allopurinol Combination Therapy by Smith, Melissa A, Blaker, Paul A, Marinaki, Anthony M, Anderson, Simon H, Irving, Peter M, Sanderson, Jeremy D

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A Biochemical Mechanism for the Role of Allopurinol in TPMT Inhibition by Blaker, Paul A, Arenas, Monica, Fairbanks, Lynette, Irving, Peter M, Marinaki, Anthony M, Sanderson, Jeremy D

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567 Optimizing the Response to Thiopurine Therapy: A Search for Novel Explanations for Thiopurine Hypermethylation by Blaker, Paul A, van Ton, Annemieke M. Peters, Arenas, Monica, Smith, Melissa A, Smith, Catherine H, Irving, Peter M, Marinaki, Anthony M, Sanderson, Jeremy D

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Detection of bowel cancer in kidney transplant recipients by Blaker, Paul A, Goldsmith, David

“…Can be achieved safely with colonoscopy screening…”
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Detection of bowel cancer in kidney transplant recipients by Blaker, Paul A, Goldsmith, David

“…Kidney transplantation is the only cure for progressive kidney failure that requires renal replacement by dialysis. This intervention is successful but limited…”
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Physiology and function of the small intestine by Blaker, Paul A, Irving, Peter

“…The small bowel is a highly adapted organ with the capacity to absorb water and nutrients far in excess of the body's requirements. Changes in absorption and…”
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Detection of bowel cancer in kidney transplant recipients: Can be achieved safely with colonoscopy screening by Blaker, Paul A, Goldsmith, David

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