Search Results - "Blakemore, Alexandra I"

Childhood Obesity Is Associated with Shorter Leukocyte Telomere Length by Buxton, Jessica L, Walters, Robin G, Visvikis-Siest, Sophie, Meyre, David, Froguel, Philippe, Blakemore, Alexandra I. F

“…The average leukocyte telomere length of obese children is 23.9% shorter than that of normal weight children of a similar age. Context: Obesity in adults is…”
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Oligogenic inheritance in severe adult obesity by Almansoori, Sumaya, Alsters, Suzanne I., Yiorkas, Andrianos M., Nor Hashim, Nikman Adli, Walters, Robin G., Chahal, Harvinder S., Purkayastha, Sanjay, Lessan, Nader, Blakemore, Alexandra I. F.

“…Background/objective The genetic architecture of extreme non-syndromic obesity in adults remains to be elucidated. A range of genes are known to cause…”
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Copy number variation at 1q21.1 associated with neuroblastoma by Diskin, Sharon J., Hou, Cuiping, Glessner, Joseph T., Attiyeh, Edward F., Laudenslager, Marci, Bosse, Kristopher, Cole, Kristina, Mossé, Yaël P., Wood, Andrew, Lynch, Jill E., Pecor, Katlyn, Diamond, Maura, Winter, Cynthia, Wang, Kai, Kim, Cecilia, Geiger, Elizabeth A., McGrady, Patrick W., Blakemore, Alexandra I. F., London, Wendy B., Shaikh, Tamim H., Bradfield, Jonathan, Grant, Struan F. A., Li, Hongzhe, Devoto, Marcella, Rappaport, Eric R., Hakonarson, Hakon, Maris, John M.

“…Copy number variation in neuroblastoma Copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) are two important potential sources of…”
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A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism by de Smith, Adam J., Purmann, Carolin, Walters, Robin G., Ellis, Richard J., Holder, Susan E., Van Haelst, Mieke M., Brady, Angela F., Fairbrother, Una L., Dattani, Mehul, Keogh, Julia M., Henning, Elana, Yeo, Giles S.H., O'Rahilly, Stephen, Froguel, Philippe, Farooqi, I. Sadaf, Blakemore, Alexandra I.F.

“…Genetic studies in patients with severe early-onset obesity have provided insights into the molecular and physiological pathways that regulate body weight in…”
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Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism by Alsters, Suzanne I M, Goldstone, Anthony P, Buxton, Jessica L, Zekavati, Anna, Sosinsky, Alona, Yiorkas, Andrianos M, Holder, Susan, Klaber, Robert E, Bridges, Nicola, van Haelst, Mieke M, le Roux, Carel W, Walley, Andrew J, Walters, Robin G, Mueller, Michael, Blakemore, Alexandra I F

“…Carboxypeptidase E is a peptide processing enzyme, involved in cleaving numerous peptide precursors, including neuropeptides and hormones involved in appetite…”
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Mendelian randomisation analyses of UK Biobank and published data suggest that increased adiposity lowers risk of breast and prostate cancer by Amin, Hasnat A., Kaewsri, Pimpika, Yiorkas, Andrianos M., Cooke, Heather, Blakemore, Alexandra I., Drenos, Fotios

“…Breast (BCa) and prostate (PrCa) cancer are the first and second most common types of cancer in women and men, respectively. We aimed to explore the causal…”
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Genetics of obesity and the prediction of risk for health by Walley, Andrew J., Blakemore, Alexandra I.F., Froguel, Philippe

“…Obesity has always existed in human populations, but until very recently was comparatively rare. The availability of abundant, energy-rich processed foods in…”
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Determinants of postprandial plasma bile acid kinetics in human volunteers by Fiamoncini, Jarlei, Yiorkas, Andrianos M, Gedrich, Kurt, Rundle, Milena, Alsters, Sanne I, Roeselers, Guus, van den Broek, Tim J, Clavel, Thomas, Lagkouvardos, Ilias, Wopereis, Suzan, Frost, Gary, van Ommen, Ben, Blakemore, Alexandra I, Daniel, Hannelore

“…Bile acids (BA) are signaling molecules with a wide range of biological effects, also identified among the most responsive plasma metabolites in the…”
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Combined effects of MC4R and FTO common genetic variants on obesity in European general populations by Cauchi, Stéphane, Stutzmann, Fanny, Cavalcanti-Proença, Christine, Durand, Emmanuelle, Pouta, Anneli, Hartikainen, Anna-Liisa, Marre, Michel, Vol, Sylviane, Tammelin, Tuija, Laitinen, Jaana, Gonzalez-Izquierdo, Arturo, Blakemore, Alexandra IF, Elliott, Paul, Meyre, David, Balkau, Beverley, Järvelin, Marjo-Riitta, Froguel, Philippe

“…Genome-wide association scans recently identified common polymorphisms, in intron 1 of FTO and 188 kb downstream MC4R , that modulate body mass index (BMI) and…”
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Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly by Wang, Jun, Li, Yingrui, Zheng, Hancheng, Luo, Ruibang, Wu, Honglong, Zhu, Hongmei, Li, Ruiqiang, Cao, Hongzhi, Wu, Boxin, Huang, Shujia, Shao, Haojing, Ma, Hanzhou, Zhang, Fan, Feng, Shuijian, Zhang, Wei, Du, Hongli, Tian, Geng, Li, Jingxiang, Zhang, Xiuqing, Li, Songgang, Bolund, Lars, Kristiansen, Karsten, de Smith, Adam J, Blakemore, Alexandra I F, Coin, Lachlan J M, Yang, Huanming, Wang, Jian

“…Identification of genomic structural variation from short-read sequencing data is typically accomplished by mapping reads to a reference genome. Li et al …”
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Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases by de Smith, Adam J., Tsalenko, Anya, Sampas, Nick, Scheffer, Alicia, Yamada, N. Alice, Tsang, Peter, Ben-Dor, Amir, Yakhini, Zohar, Ellis, Richard J., Bruhn, Laurakay, Laderman, Stephen, Froguel, Philippe, Blakemore, Alexandra I.F.

“…The discovery of copy number variation in healthy individuals is far from complete, and owing to the resolution of detection systems used, the majority of loci…”
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Relationship between BMI and emotion-handling capacity in an adult Finnish population: The Northern Finland Birth Cohort 1966 by Ramzi, Nurul Hanis, Yiorkas, Andrianos M, Sebert, Sylvain, Keinänen-Kiukaanniemi, Sirkka, Ala-Mursula, Leena, Svento, Rauli, Jokelainen, Jari, Veijola, Juha, Auvinen, Juha, Miettunen, Jouko, Dovey, Terence M, Järvelin, Marjo-Riitta, Blakemore, Alexandra I F

“…Alexithymia, a difficulty in identifying and expressing emotions, has been associated with obesity and eating disorders in small-scale cross-sectional studies…”
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Is Obesity Our Genetic Legacy? by Blakemore, Alexandra I. F., Froguel, Philippe

“…Context: To design rational management regimes and identify novel therapeutic targets, it is essential to understand the biological drivers of the current…”
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Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966 by Buxton, Jessica L, Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Couto Alves, Alexessander, Sebert, Sylvain, Millwood, Iona Y, Laitinen, Jaana, O'Reilly, Paul F, Jarvelin, Marjo-Riitta, Blakemore, Alexandra I F

“…Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere…”
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Who will benefit from bariatric surgery for diabetes? A protocol for an observational cohort study by Kenkre, Julia S, Ahmed, Ahmed R, Purkayastha, Sanjay, Malallah, Khalefah, Bloom, Stephen, Blakemore, Alexandra I, Prevost, A Toby, Tan, Tricia

“…IntroductionType 2 diabetes mellitus (T2DM) and obesity are pandemic diseases that lead to a great deal of morbidity and mortality. The most effective…”
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Urinary Sodium Excretion Enhances the Effect of Alcohol on Blood Pressure by Jiang, Xiyun, Anasanti, Mila D, Drenos, Fotios, Blakemore, Alexandra I, Pazoki, Raha

“…Alcohol consumption is linked to urinary sodium excretion and both of these traits are linked to hypertension and cardiovascular diseases (CVDs). The interplay…”
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Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine by Blakemore, Alexandra I. F., Froguel, Philippe

“…Mendelian forms of obesity are already known to account for approximately 5% of the severely obese but are currently underinvestigated. In contrast, there has…”
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Long-term unemployment is associated with short telomeres in 31-year-old men: an observational study in the northern Finland birth cohort 1966 by Ala-Mursula, Leena, Buxton, Jessica L, Ek, Ellen, Koiranen, Markku, Taanila, Anja, Blakemore, Alexandra I F, Järvelin, Marjo-Riitta

“…Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on…”
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Small deletion variants have stable breakpoints commonly associated with alu elements by de Smith, Adam J, Walters, Robin G, Coin, Lachlan J M, Steinfeld, Israel, Yakhini, Zohar, Sladek, Rob, Froguel, Philippe, Blakemore, Alexandra I F

“…Copy number variants (CNVs) contribute significantly to human genomic variation, with over 5000 loci reported, covering more than 18% of the euchromatic human…”
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Inferring combined CNV/SNP haplotypes from genotype data by Su, Shu-Yi, Asher, Julian E., Jarvelin, Marjo-Riita, Froguel, Phillipe, Blakemore, Alexandra I.F., Balding, David J., Coin, Lachlan J.M.

“…Motivation: Copy number variations (CNVs) are increasingly recognized as an substantial source of individual genetic variation, and hence there is a growing…”
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